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Acetyl-L-Carnitine Neuroprotection in Mitochondrial Dysfunction

, 2014
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Entry of acetyl-l-carnitine into biosynthetic pathways

Lipids and Lipid Metabolism, 1986
[1-14C]Acetyl-L-carnitine was injected into fed and fasted mice and the time-course of distribution of 14C in various tissues and tissue components was determined. The major product was 14CO2. However, considerable quantities of radioactivity were localized in liver with much smaller quantities in heart, brain, skeletal muscle and kidney.
L L Bieber, L L Bieber
exaly   +3 more sources

Acetyl-L-Carnitine Hydrochloride

Drugs of the Future, 1995
The title compound, 2-acetoxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride, C 9 H 18 NO 4 + .Cl - , represents a source of activated acetyl groups which are efficiently used for biosynthetic purposes. The crystal structure reported here confirms the extended conformation of the compound predicted from solid-state NMR studies and differs from ...
H. P. Weber, R. C. Anderson, M. Shapiro, E. B. Villhauer, T. Gullion   +4 more
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Uptake of acetyl-l-carnitine in the brain

Neurochemical Research, 1989
Analysis in mouse brain slices of the uptake of acetyl-L-[N-methyl-14C]carnitine with time showed it to be concentrative, and kinetic analysis gave a Km of 1.92 mM and a Vmax of 1.96 mumol/min per ml, indicating the presence of a low-affinity carrier system.
A P, Burlina, H, Sershen, E A, Debler, A, Lajtha   +3 more
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Acetyl-l-carnitine as a precursor of acetylcholine

Neurochemical Research, 1990
Synthesis of [3H]acetylcholine from [3H]acetyl-L-carnitine was demonstrated in vitro by coupling the enzyme systems choline acetyltransferase and carnitine acetyltransferase. Likewise, both [3H] and [14C] labeled acetylcholine were produced when [3H]acetyl-L-carnitine and D-[U-14C] glucose were incubated with synaptosomal membrane preparations from rat
H L, White, P W, Scates
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Acetyl‐L‐Carnitine in dementia

International Journal of Geriatric Psychiatry, 1991
AbstractThis study was designed to test the benefit of acetyl‐l‐carnitine in patients with dementia. Seventy‐one patients of 65 years and over, living in their own homes or in residential care, took part in a 24‐week randomized, double‐blind, placebo‐controlled, parallel‐group clinical trial.
G. A. Livingston, K. B. Sax, Z. McClenahan, E. Blumenthal, K. Foley, J. Willison, A. H. Mann, I. M. James   +7 more
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Acetyl-L-Carnitine in Neuropathic Pain

CNS Drugs, 2007
Acetyl-L-carnitine (ALC) has gained clinical interest for its analgesic effect in different forms of neuropathies associated with chronic pain, such as diabetic and HIV-related peripheral neuropathies. The antinociceptive effect of ALC has been confirmed in several experimental models of neuropathic pain, including streptozotocin- and chemotherapy ...
CHIECHIO, SANTINA, COPANI, Agata Graziella, GEREAU RW TH, NICOLETTI F.   +3 more
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Acetyl‐l‐carnitine for the Treatment of HIV Lipoatrophy

Annals of the New York Academy of Sciences, 2004
Abstract: Lipodystrophy is an increasingly recognized complication of antiretroviral therapy for human immunodeficiency virus (HIV) infection. This syndrome encompasses both fat accumulation and wasting, which may be accompanied by metabolic derangements in glucose and lipid metabolism.
Larry, Day, Cecilia, Shikuma, Mariana, Gerschenson   +2 more
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Acetyl-l-carnitine induces a sustained potentiation of the afterhyperpolarization

Neuroscience, 2004
Acetyl-L-carnitine is known to improve many aspects of the neural activity even if its exact role in neurotransmission is still unknown. This study investigates the effects of acetyl-L-carnitine in T segmental sensory neurons of the leech Hirudo medicinalis.
P, Lombardo, R, Scuri, E, Cataldo, M, Calvani, R, Nicolai, L, Mosconi, M, Brunelli   +6 more
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Acetyl-L-carnitine in hepatic encephalopathy

Metabolic Brain Disease, 2013
Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, and increased reaction time, sensory ...
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