Results 131 to 140 of about 396 (171)

Acetyl-l-Carnitine Treatment in Minimal Hepatic Encephalopathy

Digestive Diseases and Sciences, 2008
Minimal hepatic encephalopathy (MHE) is characterized by disturbance of mental state and neuromuscular function. To assess the clinical efficacy of acetyl-L: -carnitine (ALC) in the treatment of MHE, we performed a randomized, double-blind, placebo-controlled study administering ALC in cirrhotic patients with this disease and evaluating their cognitive
MALAGUARNERA, Mariano, GARGANTE MP, CRISTALDI E, VACANTE M, RISINO C, CAMMALLERI L, PENNISI, Giovanni, RAMPELLO, Liborio   +7 more
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Acetyl-l-carnitine as a possible therapy for Alzheimer’s disease

Expert Review of Neurotherapeutics, 2002
Alterations have been demonstrated in membrane phospholipid metabolism in Alzheimer's disease. Alterations in membrane phospholipid metabolite levels have been observed by 31P magnetic resonance spectroscopy 4 years before onset of cognitive changes. Implications of phospholipid membrane changes in Alzheimer's disease are presented.
Jay W, Pettegrew, Richard J, McClure
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Pharmacokinetics of oral acetyl-L-carnitine in renal impairment

European Journal of Clinical Pharmacology, 1990
Acetyl-L-carnitine 1.5 g and 3.0 g was administered as three divided doses on each of two occasions to 24 people with varying renal failure (creatinine clearance 127-8 ml.min-1). Plasma and urinary concentrations of total-L-carnitine, free (non-esterified) carnitine, short-chain esters and acetyl-L-carnitine were measured.
J G, Kelly, S, Hunt, G D, Doyle, M S, Laher, M, Carmody, A, Marzo, E, Arrigoni Martelli   +6 more
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Acetyl-l-carnitine: Behavioral, electrophysiological, and neurochemical effects

Neurobiology of Aging, 1993
Aged rats were chronically administered acetyl-L-carnitine (AC) for 10 months. During this period they were tested on learning and sensorimotor tasks and were then subsequently tested electrophysiologically to assess induction and decay rates of long-term synaptic enhancement (LTE) in the hippocampus. Four groups were tested: young controls (4 mo-con),
S, Davis, A L, Markowska, G L, Wenk, C A, Barnes   +3 more
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Neuroprotective activity of acetyl‐L‐carnitine: Studies in vitro

Journal of Neuroscience Research, 1994
AbstractThe neuroprotective properties of acetyl‐L‐carnitine (ALCAR) were investigated in primary cell cultures from rat hippocampal formation and cerebral cortex of 17‐day‐old rat embryos. Chronic exposure to ALCAR (10–50 μM), reduced the cell mortality induced by 24 hr fetal calf serum deprivation.
G, Forloni, N, Angeretti, S, Smiroldo
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Behavioral effects of acetyl-l-carnitine in the male rat

Pharmacology Biochemistry and Behavior, 1986
The behavioral activity of carnitine acetylate derivative, acetyl-l-carnitine has been studied in the male rat. Intraperitoneal (IP) injection of acetyl-l-carnitine was followed by an increase in ambulation and rearing items in the open field behavior.
DRAGO, Filippo, CONTINELLA G, PENNISI G, ALLORO MC, CALVANI M, SCAPAGNINI U.   +5 more
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Role of acetyl-l-carnitine in the brain: revealed by Bioradiography

Biochemical and Biophysical Research Communications, 2003
To elucidate the role of acetyl-L-carnitine in the brain, we used a novel method, 'Bioradiography,' in which the dynamic process could be followed in living slices by use of positron-emitter labeled compounds and imaging plates. We studied the incorporation of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) into rat brain slices incubated in oxygenated ...
Masaaki, Tanaka, Fusao, Nakamura, Shigekazu, Mizokawa, Akira, Matsumura, Kiyoshi, Matsumura, Yasuyoshi, Watanabe   +5 more
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The use of acetyl-L-carnitine in gerontological practice

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2017
An analysis of literature data on the acetyl-L-carnitine treatment in gerontological practice is performed. This review describes the range of biochemical activity and mechanism of action of the drug. The profile and specificity of acetyl-L-carnitine action and the possibility of combining nicergoline with other drugs is discussed.
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Acetyl l-carnitine (ALC) treatment in elderly patients with fatigue

Archives of Gerontology and Geriatrics, 2008
Fatigue is one of the conditions most frequently complained by the elderly. There are few effective treatment options for patients with chronic fatigue syndrome. To determine the efficacy, tolerability and impact on the fatigue, as well as on cognitive and functional status of elderly subjects with acetyl L-carnitine (ALC), 96 aged subjects (>70 years,
MALAGUARNERA, Mariano, GARGANTE MP, CRISTALDI E, COILONNA V, MESSANO M, KOVERECH A, NERI, Sergio, VACANTE M, CAMMALLERI L, MOTTA M.   +9 more
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Acetyl-l-carnitine reduces impulsive behaviour in adolescent rats

Psychopharmacology, 2004
The attention deficit/hyperactivity disorder (ADHD) can affect human infants and adolescents. One important feature of this disorder is behavioural impulsivity. This study assessed the ability of chronic acetyl-L-carnitine (ALC, saline or 100 mg/kg SC, plus 50 mg/kg orally) to reduce impulsivity in a validated animal model for ADHD.
Walter Adriani, REA, MONICA, Baviera, William Invernizzi, Mirjana Carli, Orlando Ghirardi, Antonio Caprioli, Giovanni Laviola   +7 more
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