Results 161 to 170 of about 25,053 (234)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Analgesic and Antidepressant Effects of the Clinical Glutamate Modulators Acetyl-L-Carnitine and Ketamine. [PDF]

Front Neurosci, 2021
Freo U, Brugnatelli V, Turco F, Zanette G.   +3 more
europepmc   +1 more source

Defining the potential antidepressant mode of action of acetyl-L-carnitine [PDF]

, 2016
Arduini, Arduino, Bonomini, Mario, Zammit, Victor A.   +2 more
core   +1 more source

Sspdhx Related to the Development and Virulence of Sclerotinia sclerotiorum Represents a Potential RNAi Target for Controlling Sclerotinia Disease

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
SsPDHX affects acetyl‐CoA and ATP metabolism and is required for normal growth, development, and pathogenicity of S. sclerotiorum. SIGS or HIGS targeting Sspdhx enhances host resistance to Sclerotinia disease. ABSTRACT Sclerotinia sclerotiorum is a destructive pathogen with a broad host range, long‐term soil survival, and is difficult to control ...
Qingna Shang, Shunrui Yang, Chunyu Feng, Chong Xie, Yunshu Song, Jiatao Xie, Yanping Fu, Jiasen Cheng, Qing Cai, Bo Li, Tao Chen, Xiao Yu, Yang Lin, Daohong Jiang, Xueqiong Xiao   +14 more
wiley   +1 more source

Assessing the antioxidant and metabolic effect of an alpha-lipoic acid and acetyl-L-carnitine nutraceutical. [PDF]

Curr Res Food Sci, 2021
Lopez-Maldonado A, Pastoriza S, Rufián-Henares JÁ.   +2 more
europepmc   +1 more source

Alternative Pathways of Acetylcholine Release in the Colon: Role of High‐Affinity Choline Transporters

Neurogastroenterology &Motility, Volume 38, Issue 3, March 2026.
Mechanisms of Acetylcholine release, including typical and atypical release under neuronal blockade. Left panel illustrates the classical (quantal) cholinergic transmission and the right panel the mechanism described in the present study. High‐Affinity Choline Transporter (HCT), Acetylcholine (ACh), Acetylcholinesterase (ACE), and Tetrodotoxin (TTX ...
A. Martinez‐Daunis, B. Yordanova, S. Traserra, P. Vergara, M. Jimenez   +4 more
wiley   +1 more source

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to acetyl-L-carnitine and contribution to normal cognitive function (ID 1432) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. [PDF]

, 2011
Abdul, Malaguarnera, Passeri, Rai, Spagnoli   +4 more
core   +1 more source

Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart

Experimental Physiology, Volume 111, Issue 3, Page 1058-1068, 1 March 2026.
Abstract The left ventricle (LV) is the primary pumping chamber of the heart, generating high systolic pressure to sustain systemic circulation. LV contractile dysfunction is a hallmark of various cardiovascular diseases and is associated with mitochondrial dysfunction, characterised by decreased oxidative phosphorylation (OXPHOS) capacity and ...
Tingting Fang, Alex Chan, Janice Chew‐Harris, Toan Pham   +3 more
wiley   +1 more source

A pilot study of maternal vitamin D status and its association with breast milk and infant gut metabolites

Physiological Reports, Volume 14, Issue 5, March 2026.
Vitamin D status in our pilot study was associated with higher levels of certain amino acids and hexanoic acid in breast milk and metabolites in infant stool samples. Abstract Human milk contains multiple bioactive components, many of which are influenced by the mother's nutritional status.
Alyssa S. Gutierrez, Katherine E. Chetta, Santosh Thapa, Sigmund J. Haidacher, Kathleen M. Hoch, John E. Baatz, Anthony M. Haag, Numan Oezguen, Thomas D. Horvath, Carol L. Wagner, Melinda A. Engevik   +10 more
wiley   +1 more source

Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain. [PDF]

Int J Mol Sci, 2021
Ardizzone A, Fusco R, Casili G, Lanza M, Impellizzeri D, Esposito E, Cuzzocrea S.   +6 more
europepmc   +1 more source