Results 31 to 40 of about 396 (171)

Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy [PDF]

Cochrane Database of Systematic Reviews, 2019
Diabetic peripheral neuropathy (DPN) is a common and severe complication that affects 50% of people with diabetes. Painful DPN is reported to occur in 16% to 24% of people with diabetes. A complete and comprehensive management strategy for the prevention and treatment of DPN, whether painful or not, has not yet been defined.Research into treatment for ...
Luiz Csp, Rolim, Edina Mk, da Silva, Ronald Lg, Flumignan, Marcio M, Abreu, Sérgio A, Dib   +4 more
openaire   +2 more sources

Requirements for Carnitine Shuttle-Mediated Translocation of Mitochondrial Acetyl Moieties to the Yeast Cytosol

mBio, 2016
In many eukaryotes, the carnitine shuttle plays a key role in intracellular transport of acyl moieties. Fatty acid-grown Saccharomyces cerevisiae cells employ this shuttle to translocate acetyl units into their mitochondria.
Harmen M. van Rossum, Barbara U. Kozak, Matthijs S. Niemeijer, James C. Dykstra, Marijke A. H. Luttik, Jean-Marc G. Daran, Antonius J. A. van Maris, Jack T. Pronk   +7 more
doaj   +1 more source

Oral Acetyl-L-Carnitine treatment in hepatic encephalopathy: view of evidence-based medicine

Annals of Hepatology, 2013
Objective. To systematically review the effect of Acetyl-L-Carnitine in patients with hepatic encephalopathy.Material and methods. Design: systematic review and meta-analysis.
Qian Jiang, Gang Jiang, Ke-qing Shi, Hong Cai, Yi-xin Wang, Ming-hua Zheng   +5 more
doaj   +1 more source

Protective Effect of Acetyl L-Carnitine on Rat Spermatogenesis Defects Induced by Lead Acetate

مجلة الانبار للعلوم البيطرية, 2023
In this study the influences of the ameliorative effects of Acetyl-L-carnitine, when exposed to lead acetate on functional aspects in spermatogenesis process in the testes of albino male rats, studied, 24 male albino rats weight 178-250 g were ...
Abd UL-Rahman Muhammed Ibrahim, Enas Osama Husain.   +1 more
doaj   +1 more source

Acetyl-L-carnitine in chronic pain: A narrative review

Pharmacological Research, 2021
Acetyl-L-carnitine (ALC) is an endogenous molecule that not only plays a role in energy metabolism, but also has antioxidant properties, protects from oxidative stress, modulates brain neurotransmitters such as acetylcholine, serotonin and dopamine, and acts on neurotrophic factors such as nerve growth factor (NGF) and metabotropic glutamate (mGlu ...
Sarzi-Puttini P., Giorgi V., Di Lascio S., Fornasari D.   +3 more
openaire   +2 more sources

The Protective Effects of Acetyl L-Carnitine on Testis Gonadotoxicity Induced by Cisplatin in Rats

Balkan Medical Journal, 2013
Background: Cisplatin, an effective antineoplastic agent, damages normal cells in a manner related to chemotherapy. Acetyl L-carnitine protects cells against mitochondrial and nuclear damage induced by chemotherapy. Aims: The aim of this study was to
Neslihan Coşkun, M. Tahir Hatipoğlu, Candan Özoğul, Seda Nur Akyol, Gülistan Sanem Arık, Deniz Erdoğan, Cem Korkmaz, Serap Cilaker Mıcılı   +7 more
doaj   +1 more source

Retrospective observational study on the use of acetyl-l-carnitine in ALS

Journal of Neurology, 2023
AbstractALCAR (Acetyl-L-carnitine) is a donor of acetyl groups and increases the intracellular levels of carnitine, the primary transporter of fatty acids across the mitochondrial membranes. In vivo studies showed that ALCAR decrease oxidative stress markers and pro-inflammatory cytokines.
Sassi S., Bianchi E., Diamanti L., Tornabene D., Sette E., Medici D., Mata S., Leccese D., Sperti M., Martinelli I., Ghezzi A., Mandrioli J., Iuzzolino V. V., Dubbioso R., Trojsi F., Passaniti C., D'Alvano G., Filosto M., Padovani A., Mazzini L., De Marchi F., Zinno L., Nuredini A., Bongioanni P., Dolciotti C., Canali E., Toschi G., Petrucci A., Perna A., Riso V., Inghilleri M., Libonati L., Cambieri C., Pupillo E.   +33 more
openaire   +7 more sources

Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva

Membranes, 2023
The development of accessible express methods to determine markers of viral diseases in saliva is currently an actual problem. Novel cross-sensitive sensors based on Donnan potential with bio-comparable perfluorosulfonic acid membranes for the ...
Anna V. Parshina, Ekaterina Yu. Safronova, Svetlana A. Novikova, Nastasia Stretton, Anastasia S. Yelnikova, Timur R. Zhuchkov, Olga V. Bobreshova, Andrey B. Yaroslavtsev   +7 more
doaj   +1 more source

Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. [PDF]

PLoS ONE, 2015
Angiotensin II promotes insulin resistance. The mechanism underlying this abnormality, however, is still poorly defined. In a different setting, skeletal muscle metabolism and insulin signaling are regulated by Sirtuin3.Here, we investigate whether ...
Daniela Macconi, Luca Perico, Lorena Longaretti, Marina Morigi, Paola Cassis, Simona Buelli, Norberto Perico, Giuseppe Remuzzi, Ariela Benigni   +8 more
doaj   +1 more source

Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats [PDF]

Neuropharmacology, 2002
The analgesic activity of acetyl-L-carnitine (ALCAR) in neuropathic pain is well established. By contrast, its potential efficacy in the relief of acute pain has not been reported. The antinociceptive effect of ALCAR was, therefore, examined in the mouse hot-plate and abdominal constriction tests, and in the rat paw-pressure test.
GHELARDINI, CARLA, GALEOTTI, NICOLETTA, M. CALVANI, L. MOSCONI, R. NICOLAI, BARTOLINI, ALESSANDRO   +5 more
openaire   +2 more sources