Results 61 to 70 of about 396 (171)
Acetyl-L-carnitine protective role in gemcitabine-induced neurotoxicity in an experimental rat model
Open Veterinary JournalBackground: The acetyl ester of L-carnitine (ALC) is essential for cellular energy homeostasis and intermediate metabolism. It demonstrates several well-established biological characteristics, such as antioxidant activity, intracellular membrane ...
Marwa Sabah Majed +5 more
doaj +1 more source
Anxiolytic and anti-stress effects of acute administration of acetyl-L-carnitine in zebrafish [PDF]
PeerJ, 2018 Studies have suggested that oxidative stress may contribute to the pathogenesis of mental disorders. In this context, molecules with antioxidant activity may be promising agents in the treatment of these deleterious conditions.
Lais Pancotto +4 more
doaj +2 more sources
Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors
International Journal of Cancer, EarlyView.ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan +6 more
wiley +1 more source
Second‐trimester multimetabolite panel for early preeclampsia rule‐out
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective We aimed to establish a high‐sensitivity, multimetabolite rule‐out model for the development of preeclampsia (PE), prioritizing minimizing false negatives to exclude low‐risk individuals from intensive surveillance confidently. Methods In this prospective, nested case–control study, maternal serum samples were collected between 20+0 ...
Matthews Silva Martins +7 more
wiley +1 more source
Advanced ScienceMetabolic dysfunction‐associated steatohepatitis related hepatocellular carcinoma (MASH‐HCC) is a distinct HCC subtype characterized by lipid accumulation, impaired fatty acid oxidation (FAO), immune evasion, and resistance to immunotherapy.
Chuqi Xia +11 more
doaj +1 more source
Bile acid metabolism and signaling in human and animal health: A One Health perspective
iMetaOmics, EarlyView.Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li +7 more
wiley +1 more source
Modulation of cytokine production by carnitine
Mediators of Inflammation, 1993 The ability of carnitine congeners to modulate cytokine production by human peripheral blood mononuclear cells (PBMC) was investigated. Modulation of cytokine production by PBMC of young (30 years of age or younger) and old (70 years of age or older ...
Nicola M. Kouttab, Claudio De Simone
doaj +1 more source
Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention
iMetaOmics, EarlyView.The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie +12 more
wiley +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Медицинский совет, 2015 Depression is the third most common cause of disability in the world's population. Depressive disorders are widespread in patients observed by psychiatrists, neurologists, as well as general practitioners.
V. A. Golovacheva, V. A. Parfyonov
doaj +1 more source