Results 131 to 140 of about 204,757 (287)

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

BIOTRANSFORMACIÓN DE trans-CINAMALDEHÍDO CON EL HONGO FILAMENTOSO Aspergillus sp. BIOTRANSFORMATION OF trans-CINNAMALDEHYDE BY THE FILAMENTOUS FUNGUS Aspergillus sp

Vitae, 2010
El desarrollo de métodos biocatalíticos ha permitido la preparación de una amplia variedad de productos con alto valor agregado a través de procesos simples, selectivos, económicos y respetuosos con el medio ambiente.
Rodrigo VELASCO B, Diego A ARISTIZABAL, Carlos M GARCÍA P, Jesús H GIL G, Diego L DURANGO R   +4 more
doaj  

Reversible Protein Acetylation in the Regulation of Mammalian Hibernation

, 2014
Andrew Rouble
openalex   +2 more sources

ADA2 Forms Nuclear Condensates with GCN5 and ATP‐Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems

Advanced Science, EarlyView.
This study unveils a novel GAA (GCN5‐ADA2‐ACL) complex that forms nuclear condensates to boost local acetyl‐CoA, facilitating histone acetylation and gene transcription in rice meristems. The research underscores the role of ADA2's disordered region in complex condensation and ACL's role in acetyl‐CoA production.
Yaping Yue, Tingting Lu, Xiaoyuan Guo, Biao Liu, Shiteng Lv, Heba A. M. Abdalla, Xuelei Lai, Ruihui Zhang, Jianpin Guo, Yu Zhao, Dao‐Xiu Zhou, Shaoli Zhou   +11 more
wiley   +1 more source

Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation. [PDF]

Cell Death Discov
Lu W, Deng Y, Liu M, Hu Y, Yang K, Wang B, Li Y, Wang G, Ma L, Liu J, Xie Y, Li Q, Liu A, Zhang X, Xie P.   +14 more
europepmc   +1 more source

The effects of acetylation on properties of flax fibre and its polypropylene composites

, 2008
Andrzej K. Błędzki, Abdullah Al Mamun, M. Lucka-Gabor, Voytek S. Gutowski   +3 more
openalex   +1 more source

Acetylation.

Experimental Biology and Medicine, 1927
B. Harrow, F. W. Power, C. P. Sherwin
openaire   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders. [PDF]

Int J Biol Sci
Xu L, Shen C, Liu X, Qin Y, Wu Z, Zhang Z, Sheng Q, Wang Q, Zhou F, Ge G, Geng D.   +10 more
europepmc   +1 more source