Results 121 to 130 of about 206,586 (259)

Entinostat plus exemestane for hormone receptor-positive advanced breast cancer: long-term overall survival results from the EOC103A3101 randomized controlled trial. [PDF]

Signal Transduct Target Ther
Wang J, Zhang Q, Hu X, Sun T, Li W, Ouyang Q, Wang J, Tong Z, Yan M, Li H, Zeng X, Shan C, Wang X, Zhang J, Zhang Y, Zhang L, Shang H, Xu B.   +17 more
europepmc   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Influence of Histone Acetylation on Chromatin 3D Organization in <i>Drosophila</i> S2 Cells. [PDF]

Int J Mol Sci
Kononkova AD, Ulianov SV, Tiukacheva EA, Mikhaleva EA, Doronin SA, Kobets VA, Khrameeva EE, Razin SV, Shevelyov YY.   +8 more
europepmc   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Acetylation promotes thyroid hormone receptor ubiquitination and degradation by nuclear proteasomes. [PDF]

Mol Cell Endocrinol
Christmas SL, Strauss RI, Simsek YK, Rosenthal MI, White OA, Shapira ME, Alsayed H, Yan Y, De La Rosa Martinez J, Roggero VR, Allison LA.   +10 more
europepmc   +1 more source

Histone Acetylation Dynamics Regulate Fungal Development, Pathogenicity, and Mycotoxin Biosynthesis. [PDF]

J Fungi (Basel)
Gong C, Li Z, Xu D, Sun D, Wang Z, Du X, Zhang Y, Qi X.   +7 more
europepmc   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Research progress on lysine acetylation (Review). [PDF]

Int J Mol Med
Zhang M, Zhang Y, Yin H, Yan J, Dong Y, Zhao X, Cui T, Lv B, Gao X.   +8 more
europepmc   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Acetylation enables a dual-targeting fungal effector to inhibit insect immunity and development. [PDF]

PLoS Pathog
Wang Y, Dong Y, Zhang Y, Wu S, Yu D, Yang G, Gao S, Yang Y, Dong S, Qin L, Huang B.   +10 more
europepmc   +1 more source