Results 111 to 120 of about 337,770 (296)
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Acetylation phenotype in squamous cell lung cancer
JKS (Jurnal Kedokteran Syiah Kuala), 2009 Abstrak. Risiko kanker dipengaruhi oleh faktor host dan lingkungan. Bahan dari lingkungan yang banyak menyebabkan kanker paru-paru adalah metabolite dalam asap rokok, Squamous sel kanker paru-paru merupakan jenis
Mulyadi Mulyadi
doaj
Defining the chromatin signature of inducible genes in T cells [PDF]
, 2016 BACKGROUND Specific chromatin characteristics, especially the modification status of the core histone proteins, are associated with active and inactive genes. There is growing evidence that genes that respond to environmental or developmental signals may
Bunting, Karen +6 more
core +1 more source
De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Advanced Science, EarlyView.Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li +23 more
wiley +1 more source
Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]
, 2012 Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
core +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Proceedings of the National Academy of Sciences, 1955 A K, Balls, F L, Aldrich
openaire +2 more sources
Histone Acetylation and Cancer
Acta Oncologica, 2003 Acta Oncologica Vol. 42, No. 7, p. 792, 2003Received 7 March 2003Accepted 14 April 2003To the Editor:The organization of chromatin is crucial for the regulation of geneexpression. In particular, both the positioning and properties ofnucleosomes influence promoter-specific transcription in responseto extracellular or intracellular signals (1).
Kouraklis, G, Theocharis, S
openaire +3 more sources
Advanced Science, EarlyView.Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang +8 more
wiley +1 more source
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity [PDF]
, 2019 The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is ...
Backe, Sarah J +11 more
core +1 more source