Results 131 to 140 of about 230,380 (304)
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
Hemp reinforced composites with alkalization and acetylation fibre treatments
, 2014 The increasing ecological and environmental concerns have led to the development of natural fibre composites. Chemical treatments are usually used to modify the surface of fibre to improve the bonding between fibre and resin. Alkalization and acetylation
Kabir, M. M., Wang, H., Lau, K. T.
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Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos
Advanced Science, EarlyView.Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan +8 more
wiley +1 more source
Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance
Advanced Science, EarlyView.Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes +4 more
wiley +1 more source
Regulation of SIK2 Activity by Acetylation
, 2007 第二型鹽誘導激酶（SIK2）為一種絲胺酸/蘇胺酸蛋白質激酶（Serine/threonine protein kinase），並屬於單磷酸腺苷蛋白質激酶（AMPK）族系的其中一個成員。過去的研究顯示，此蛋白質在成熟的脂肪細胞中大量表現並且在脂肪細胞分化過程中具有調控早期胰島素傳導的功能。迄今，除了IRS-1和TOC2外，對於SIK2其他生理上的受質仍未非常明暸。第一型胰島素受器受質（IRS-1）在脂肪組織的胰島素傳導中扮演重要的功能，並且被認為在第794位置的絲胺酸上會被SIK2磷酸化 ...
Sun, Huei-Yu, 孫惠鈺
core
Post-translational modifications (PTMs) represent a dynamic and intricate layer of cellular regulation that significantly contributes to the diversification of protein functions (1).
Syon, Schlecht +2 more
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Comparison of sequence information between acetylation sites and non-acetylation sites.
, 2012 (A) Amino acid average composition of acetylation and non-acetylation sites. (B) A two-sample logo of the compositional biases around the acetylation sites compared to the non-acetylation sites.
Jian-Ding Qiu (118622) +6 more
core +1 more source
Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation
Advanced Science, EarlyView.Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang +4 more
wiley +1 more source
, 2004 Fourier transform infrared (FTIR) and C-13 MAS NMR spectroscopy have been used to investigate the acetylation of raw cotton samples with acetic anhydride without solvents in the presence of different amounts of 4-dimethylaminopyridine (DMAP) catalyst ...
Adebajo, Moses O. +3 more
core +1 more source