Results 141 to 150 of about 374,029 (398)
Virtual screening and lead optimisation to identify novel inhibitors for HDAC-8 [PDF]
arXiv, 2012 Histone deacetylase (HDAC) and Histone acetyl-transferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the (epsilon)-amino groups of lysine located near the amino termini of core histone proteins. Over expression of HDACs noted in many forms of cancers including leukemia and breast cancer.
arxiv
Mechanisms, Detection, and Relevance of Protein Acetylation in Prokaryotes
mBio, 2019 Posttranslational modification of a protein, either alone or in combination with other modifications, can control properties of that protein, such as enzymatic activity, localization, stability, or interactions with other molecules.
David G. Christensen +7 more
semanticscholar +1 more source
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability [PDF]
, 2017 R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive regulatory roles but are also a source of genomic instability.
Aguilera López, Andrés +5 more
core +1 more source
Acetyl Content of Marinobufagin, Arenobufagin and Acetyl-marinobufagin [PDF]
Nature, 1940 FOR marinobufagin, first isolated by Abel and Maeht1 from Bufo marinus and afterwards by Deulofeu and Mendive2 from B. paracnemis, Slotta and Neisser3 suggested the formula C27H38O6, at variance with C24H32O5 accepted by Jensen in many of his papers. They supposed that mar inobuf agin could contain one propionyl group.
E. Duperat, R. Labriola, V. Deulofeu
openaire +2 more sources
Bioprinted Micro‐Clots for Kinetic Analysis of Endothelial Cell‐Mediated Fibrinolysis
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.This paper describes the development of a microscale model that quantifies the breakdown of fibrin by endothelial cells. The small size scale of this engineered system enables fibrin breakdown to be observed without the addition of external activators. This system could help in identifying compounds which both promote and hinder thrombosis.
Jonathan J. Chang +5 more
wiley +1 more source
Protein Acetylation in Bacteria.
Annual Review of Microbiology, 2019 Acetylation is a posttranslational modification conserved in all domains of life that is carried out by N-acetyltransferases. While acetylation can occur on Nα-amino groups, this review will focus on Nε-acetylation of lysyl residues and how the ...
Chelsey M. VanDrisse +1 more
semanticscholar +1 more source
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity [PDF]
, 2019 The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is ...
Backe, Sarah J +11 more
core +1 more source
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.A 3D bioprinted HNSCC model for use in anti‐cancer drug testing is established in proof‐of‐concept. The innovative tunicate‐derived nanocellulose hydrogel proved to be a viable alternative to gelatin‐based hydrogel, offering improved bioprintability for HNSCC model establishment.
Alexya Azhakesan +7 more
wiley +1 more source
Synthesis, Characterization, and Application of a Bio-Based Plasticizer for PVC: Epoxidized Acetylation Cardanol [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2019 A bio-based plasticizer, epoxidized acetylation cardanol, was synthesized from cardanol, which experienced acetylation reaction and epoxidation reaction.
Yufeng Ma +5 more
doaj
Insights into pectin O-acetylation in the plant cell wall: structure, synthesis, and modification
The Cell Surface, 2023 O-Acetyl esterification is an important structural and functional feature of pectins present in the cell walls of all land plants. The amount and positions of pectin acetyl substituents varies across plant tissues and stages of development.
Lubana Shahin +3 more
doaj