Mechanism of crosstalk between DNA methylation and histone acetylation and related advances in diagnosis and treatment of premature ovarian failure. [PDF]
EpigeneticsLi J +6 more
europepmc +1 more source
THE EFFECT OF ENZYME ACETYLATION ON THE KINETICS OF THE CARBOXYPEPTIDASE-A-CATALYZED HYDROLYSIS OF HIPPURYL-L-β-PHENYLLACTIC ACID [PDF]
, 1965 Myron L. Bender +2 more
openalex +1 more source
A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain
Advanced Science, EarlyView.Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria +5 more
wiley +1 more source
Set1 is a critical transcriptional regulator in response to external signals in Candida albicans. [PDF]
Nucleic Acids ResKim J, Park J, Lee EJ, Cho YJ, Lee JS.
europepmc +1 more source
Corrigenda - Hydroxamic acids. II. The acetylation of O-alkylhydroxamic acids [PDF]
, 1969 MTW Hearn, A. David Ward
openalex +1 more source
Advanced Science, EarlyView.L14‐8, a small molecule derived from the marketed drug ezetimibe, potently inhibits advanced prostate cancer independent of androgen receptor signaling. L14‐8 binds PLK1, triggering its ubiquitin‐mediated degradation. This activates TP53‐dependent transcription of SAT1, inducing ferroptosis and suppressing tumor growth in prostate cancer patient ...
Yu Zhang +8 more
wiley +1 more source
Reduced fungal protein acetylation mediates the antimicrobial activity of a rhizosphere bacterium against a phytopathogenic fungus. [PDF]
Nat CommunZhang YC +6 more
europepmc +1 more source
Preparation of Acetate Rayon by the Acetylation of Viscose Rayon with Acetic Anhydride Vapor
, 1953 Ichiro Sakurada +2 more
openalex +2 more sources
High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics
Advanced Science, EarlyView.The systematic tiling of essential genes’ mRNA here presented, proposes a valuable tool for the identification of novel PNA sequences with antibiotic potential. The high‐throughput synthetic set up opens the door to investigating thousands of sequences in an economic way and ultimately identifies potent antisense oligonucleotides while also giving room
Giorgia Danti +3 more
wiley +1 more source