Results 211 to 220 of about 374,029 (398)

Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling

Advanced Science, EarlyView.
The comprehensive proteomic and N‐glycoproteomic analyses of 45 colorectal cancer tissues with matched normal adjacent tissues identified 7125 intact N‐glycopeptides from 704 glycoproteins. A glycosylation site‐protein function network revealing metabolic dysregulation is constructed and a model differentiating tumors from normal tissues is developed ...
Guobin Liu, Lu Chen, Jingxiang Zhao, Yue Jiang, Yarong Guo, Xiang Mao, Xuelian Ren, Kun Liu, Qi Mei, Qunyi Li, He Huang   +10 more
wiley   +1 more source

Preparation of Acetate Rayon by the Acetylation of Viscose Rayon with Acetic Anhydride Vapor

, 1953
Ichiro Sakurada, Yasuyoshi Sakaguchi, T. Morita   +2 more
openalex   +2 more sources

IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation

Advanced Science, EarlyView.
IR783‐stabilized nanodrugs composed of NIR dye IR783, ROS inducer β‐lapachone, and epigenetic modulator CUDC101 are designed for breast cancer immunotherapy. The nanodrugs can not only promote cancer cell apoptosis through HDAC inhibition‐enhanced oxidation therapy but also reshape the immunosuppressive microenvironment, which provides a novel strategy
Jinzhao Liu, Meicen Wu, Qingyang Lyu, Chang Yang, Ni Fan, Kang Chen, Weiping Wang   +6 more
wiley   +1 more source

Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity

Journal of Lipid Research, 2012
Acetylation is one of the most crucial post-translational modifications that affect protein function. Protein lysine acetylation is catalyzed by acetyltransferases, and acetyl-CoA functions as the source of the acetyl group.
Eun Young Kim, Won Kon Kim, Hyo Jin Kang, Jeong-Hoon Kim, Sang J. Chung, Yeon Soo Seo, Sung Goo Park, Sang Chul Lee, Kwang-Hee Bae   +8 more
doaj  

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Combining transition path sampling with data-driven collective variables through a reactivity-biased shooting algorithm [PDF]

arXiv
Rare event sampling is a central problem in modern computational chemistry research. Among the existing methods, transition path sampling (TPS) can generate unbiased representations of reaction processes. However, its efficiency depends on the ability to generate reactive trial paths, which in turn depends on the quality of the shooting algorithm used.
arxiv  

THE EFFECT OF PANTOTHENIC ACID DEFICIENCY ON ACETYLATION IN RATS

, 1948
Thomas R. Riggs, D.M. Hegsted
openalex   +1 more source

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advanced Science, EarlyView.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
wiley   +1 more source

A Curated Rotamer Library for Common Post-Translational Modifications of Proteins [PDF]

arXiv
Sidechain rotamer libraries of the common amino acids of a protein are useful for folded protein structure determination and for generating ensembles of intrinsically disordered proteins (IDPs). However much of protein function is modulated beyond the translated sequence through thFiguree introduction of post-translational modifications (PTMs). In this
arxiv  

STUDIES IN ACETYLATION. THE FATE OF p-AMINOBENZOIC ACID IN THE RABBIT

, 1933
Benjamin Harrow, Abraham Mazur, Carl P. Sherwin   +2 more
openalex   +1 more source