Results 221 to 230 of about 199,012 (297)

Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition

Advanced Science, EarlyView.
At 2 5 °C, thermal activation initiates: i) CcIav/CcNan heterotetramer assembly → Ca2⁺ influx; ii) CcPKCα phosphorylation → AKH signaling potentiation; iii) CcAKH1 binding to membrane‐localized CcAKHR → energy mobilization (lipid catabolism/glycogenolysis) and vitellogenin transport via follicular patency; iv) Oocyte maturation → summer‐form nymph ...
Jianying Li, Zhixian Zhang, Yilin Wang, Yue Yang, Jiarui Wang, Xueyi Ruan, Songdou Zhang   +6 more
wiley   +1 more source

Co-Regulation of Very Fast Chilling Treatment and the Follow-Up Storage Temperature on Meat Tenderness Through Glycolysis. [PDF]

Foods
Bai Y, Ren C, Wu S, Hou C, Li X, Zhang D.   +5 more
europepmc   +1 more source

The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice

Advanced Science, EarlyView.
Piezo1 upregulates in cartilage callus during bone repair, where its deletion impairs ossification and healing in mice, while activation enhances these processes. Sirt1 positively regulates Piezo1 expression and activity to promote osteogenesis and bone repair in mice.
Donghao Gan, Yi Ran, Hong Pan, Qinnan Yan, Wenjing Zhang, Bo Zhou, Pengzhi Xu, Rongdong Liao, Haipeng Xue, Will Jiang, Tailin He, Qingyun Jia, Lei Qin, Francis Y Lee, Di Chen, Chuanju Liu, Guozhi Xiao   +16 more
wiley   +1 more source

ING5: multifaceted roles beyond tumor suppression in cellular physiology and disease. [PDF]

Epigenetics Chromatin
Liao J, Zhang X, Chen Z, Liao Y.
europepmc   +1 more source

Radiolabeling of proteins and viruses in vitro by acetylation with radioactive acetic anhydride.

, 1975
Ronald C. Montelaro, Roland R. Rueckert
openalex   +1 more source

EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib‐Resistant Lung Cancer Therapy

Advanced Science, EarlyView.
In this study, an EGFR lipoSM PROTACs (GM‐protac), which can achieve efficient EGFR degradation and HDACi delivery, is developed. It is found that GM‐protac can both block EGFR‐dependent pathways and bypass the HDAC signaling pathway. Meanwhile, both display obvious tumor inhibition with negligible toxicity in EGFR‐TKI‐resistant lung cancer animal ...
Dongyuan Wang, Yajing Liu, Ying Chen, Chuan Dai, Wenzhu Hu, Jinyan Han, Zigang Li, Feng Yin, Yu Zhang, Chen Shi   +9 more
wiley   +1 more source

Correction to "Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging". [PDF]

MedComm (2020)
europepmc   +1 more source

Acetylation of lysine 49 on Ctnnb1 drives naïve pluripotency in murine stem cells by modulating Nanog function. [PDF]

PNAS Nexus
Takehara T, Nakanishi M, Son R, Suemori H, Murakawa Y, Teramura T.   +5 more
europepmc   +1 more source

Steric‐Adaptive Biocatalysis: Imine Reductase‐Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines

Advanced Science, EarlyView.
An unusual IRED platform is reported, enabling efficient DKR via reductive amination without any evolutionary engineering. The system accommodates extremely sterically demanding substrates, including naphthyl and quinoline derivatives, delivering naphthyl‐aryl and quinoline‐aryl amine atropisomers with excellent efficiency and stereocontrol (over 80 ...
Zhichao Ni, Jingyuan Zhuang, Yadong Gao, Guangsheng Gao, Zhenling Liu, Ping Su, Gui‐Juan Cheng, Li‐Cheng Yang   +7 more
wiley   +1 more source

Mechanistic insights into post-translational modifications in hepatic fibrosis: pathogenic roles and therapeutic potentials. [PDF]

J Transl Med
Bai X, Liu Z, Li X, Sun R, Yu Z.
europepmc   +1 more source