miR-223-3p improves macrophage polarization balance and mitochondrial metabolism to ameliorate uveitis by orchestrating P65<sup>Lys310</sup> acetylation through RBPJ/HDAC1 axis. [PDF]
Peng Y +12 more
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Acetylation dynamics of MrATG4 governing autophagy-mediated conidiation in an entomopathogenic fungus. [PDF]
Yu D +10 more
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Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells. [PDF]
Kienle SM +9 more
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Uncovering the acetylation sites of Dnmt3L that regulate protein stability and differentiation potency in embryonic stem cells. [PDF]
Nam YJ +20 more
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A Proteomic Study of the Dual Oncogenic and Tumor-Suppressive Roles of SIRT3 in Lung and Breast Cancer Cell Lines. [PDF]
Ayala Reyes M +5 more
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Dysregulated post‑translational modifications in granulosa cells drive ovarian dysfunction and potential infertility applications (Review). [PDF]
Zhong Y +5 more
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Acetyl-CoA, protein acetylation, and liver cancer
Molecular Cell, 2022Using multi-omics approaches, Park et al. show that reduced cellular acetyl-CoA and protein hypoacetylation promote liver cancer growth and dedifferentiation.
Zhengming, Wu, Kun-Liang, Guan
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Nonenzymic acetylation of histones with acetyl phosphate and acetyl adenylate
Biochemistry, 1975Nonenzymatic acetylation of calf-thymus lysine- and arginine-rich histones was demonstrated to occur when these proteins were incubated with [14C]acetyl phosphate and [14C]acetyl adenylate. The levels of acetylation depend on both pH and on reagent concentration.
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Clonazepam acetylation in fast and slow acetylators
Clinical Pharmacology and Therapeutics, 1981Six slow acetylators (SAs) and six rapid acetylators (RAs), as determined by sulfamethazine (SMZ) phenotyping, were each given a 2-mg oral dose of clonazepam. Ninety-six-hour urine collections from these subjects were analyzed for clonazepam, 7-amino clonazepam (7-AM, clonazepam nitroreduced metabolite), and 7-acetamido clonazepam (7-ACT, N-acetylated ...
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