Results 51 to 60 of about 199,012 (297)

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Smad1 Promotes Tumorigenicity and Chemoresistance of Glioblastoma by Sequestering p300 From p53

Advanced Science
Acetylation is critically required for p53 activation, though it remains poorly understood how p53 acetylation is regulated in glioblastoma (GBM). This study reveals that p53 acetylation is a favorable prognostic marker for GBM, regardless of p53 status,
Lingli Gong, Daxing Xu, Kaixiang Ni, Jie Li, Wei Mao, Bo Zhang, Zhening Pu, Xiangming Fang, Ying Yin, Li Ji, Jingjing Wang, Yaling Hu, Jiao Meng, Rui Zhang, Jiantong Jiao, Jian Zou   +15 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Epigenetic Alterations in Immune Cells of Systemic Lupus Erythematosus and Therapeutic Implications

Cells, 2022
Systemic lupus erythematosus (SLE) is an autoimmune disorder that is characterized by autoantibody production and dysregulated immune cell activation.
David E. Adams, Wen-Hai Shao
doaj   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

The world of protein acetylation

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2016
Acetylation is one of the major post-translational protein modifications in the cell, with manifold effects on the protein level as well as on the metabolome level. The acetyl group, donated by the metabolite acetyl-coenzyme A, can be co- or post-translationally attached to either the α-amino group of the N-terminus of proteins or to the ε-amino group ...
Adrian Drazic, Rasmus Ree, Line M. Myklebust, Thomas Arnesen, Thomas Arnesen   +4 more
openaire   +3 more sources

Functionalized Lignin Derivatives as Melt‐Spinnable Precursors for Carbon Fiber Production without Stabilization

Advanced Functional Materials, EarlyView.
By turning off hydrogen bonds by bulky ethyl cinnamate ester derivatization, softwood kraft lignin can flow under elevated temperatures, providing tough fiber in the melt for high take‐up speed. Subsequently, lignin ethyl cinnamate derivatives are readily stabilized with only dilute nitric acid leading to direct carbonized fiber with outstanding ...
Qi Hua, Muzaffer A. Karaaslan, Zhixin Huang, Lingyan Fang, Jie Wu, Huaiyu Zhang, Yuhang Ye, Yasmine Abdin, Scott Renneckar   +8 more
wiley   +1 more source

Unlock the Walnut: How a Pectin‐Rich Suture Tissue and Moisture‐Driven Crack Formation Induce Shell Splitting and Facilitate Seed Germination

Advanced Functional Materials, EarlyView.
Walnut seeds are enclosed in a remarkably strong shell made of sclerenchyma, separated by a pectin‐rich suture tissue. Different cell shapes and chemical composition of this tissue point to an opening mechanism, which is triggered by cyclic humidity changes.
Sebastian J. Antreich, Nannan Xiao, Martin Felhofer, Notburga Gierlinger   +3 more
wiley   +1 more source

Matrix stiffness‐induced α‐tubulin acetylation is required for skin fibrosis formation through activation of Yes‐associated protein

MedComm, 2023
Skin fibrosis, a pathological process featured by fibroblast activation and extracellular matrix (ECM) deposition, makes a significant contribution to morbidity.
Dongsheng Wen, Ya Gao, Yangdan Liu, Chiakang Ho, Jiaming Sun, Lu Huang, Yuxin Liu, Qingfeng Li, Yifan Zhang   +8 more
doaj   +1 more source