Results 51 to 60 of about 204,757 (287)

Promotion of Lung Cancer Metastasis by SIRT2‐Mediated Extracellular Protein Deacetylation

Advanced Science, 2023
Acetylation of extracellular proteins has been observed in many independent studies where particular attention has been given to the dynamic change of the microenvironmental protein post‐translational modifications.
Meng Wu, Jian‐Bin Zhang, Yi‐Wei Xiong, Yong‐Xu Zhao, Meng‐Ge Zheng, Xia‐Li Huang, Fang Huang, Xing‐Xing Wu, Xue Li, Wei‐Jiao Fan, Lin Hu, Yuan‐Yuan Zeng, Xia‐Ju Cheng, Ji‐Cheng Yue, Juan‐Juan Du, Nan‐Nan Chen, Wen‐Xiang Wei, Qing‐Hua Yao, Xiao‐mei Lu, Chao Huang, Jiong Deng, Zhi‐Jie Chang, He‐Bin Liu, Ting C. Zhao, Y. Eugene Chinn   +24 more
doaj   +1 more source

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory [PDF]

Nature, 2017
Metabolic production of acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation and gene regulation, but the precise mechanisms of this process are largely unknown. Here we show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) directly regulates histone acetylation in neurons and spatial memory in mammals.
Mews, Philipp, Donahue, Greg, Drake, Adam M., Luczak, Vincent, Abel, Ted, Berger, Shelley L.   +5 more
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

Cell Reports, 2019
Summary: Neuronal activity-inducible gene transcription correlates with rapid and transient increases in histone acetylation at promoters and enhancers of activity-regulated genes.
Liang-Fu Chen, Yen Ting Lin, David A. Gallegos, Mariah F. Hazlett, Mariana Gómez-Schiavon, Marty G. Yang, Breanna Kalmeta, Allen S. Zhou, Liad Holtzman, Charles A. Gersbach, Jörg Grandl, Nicolas E. Buchler, Anne E. West   +12 more
doaj   +1 more source

Sustainable Synthesis of Bio‐Based Magnetic and Conductive Wood for Electromagnetic Interference Shielding Applications

Advanced Engineering Materials, EarlyView.
A wood‐based magnetic and conductive material called Magwood (MW), capable of blocking almost 99.99% of electromagnetic waves (in the X‐band frequency range), is synthesized using a simple, solvent‐free process. MW is lightweight, resists water, and is flame‐retardant, making it a promising alternative for shielding electronics. The rapid proliferation
Akash Madhav Gondaliya, Majed Amini, Mohammad Arjmand, Earl Johan Foster   +3 more
wiley   +1 more source

Acetylation, Deacetylation and Acyltransfer [PDF]

Environmental Health Perspectives, 1983
N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. Decreasing the levels of metabolites,
C M, King, I B, Glowinski
openaire   +2 more sources

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Microtubule acetylation is not required for HIV-1 infection or TRIM69-mediated restriction of HIV-1 infection

Journal of Virology
Microtubule acetylation, a post-translational modification catalyzing the addition of acetyl groups to lysine residues on alpha tubulin, confers mechanical resilience to microtubules and influences intracellular cargo transport.
Drew M. Lichon, Natalie J. LoMascolo, Bryan C. Mounce, Edward M. Campbell   +3 more
doaj   +1 more source

Preparation and structural characterization of O-acetyl agarose with low degree of substitution

Polímeros, 2000
Among the biodegradable polymers, the polysaccharides have been found to be promising carriers for bioactive molecules. From a general standpoint, they present several reactive groups, such as hydroxyl, carboxyl and amine, that can be modified in a ...
Rosangela B. Garcia, Rosangela R. L. Vidal, Marguerite Rinaudo   +2 more
doaj   +1 more source

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration

Advanced Healthcare Materials, EarlyView.
Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan   +9 more
wiley   +1 more source