Results 71 to 80 of about 337,770 (296)

Acetylation Goes Global: The Emergence of Acetylation Biology [PDF]

Science Signaling, 2009
Proteomic analysis shows protein acetylation to be more prevalent than previously appreciated.
Kristi L, Norris, Joo-Yong, Lee, Tso-Pang, Yao   +2 more
openaire   +2 more sources

Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene [PDF]

, 2010
[No abstract ...
CANETTIERI, Gianluca, CONI, SONIA, DI MARCOTULLIO, LUCIA, GRECO, Azzura, GULINO, Alberto   +4 more
core   +1 more source

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source

Promotion of Lung Cancer Metastasis by SIRT2‐Mediated Extracellular Protein Deacetylation

Advanced Science, 2023
Acetylation of extracellular proteins has been observed in many independent studies where particular attention has been given to the dynamic change of the microenvironmental protein post‐translational modifications.
Meng Wu, Jian‐Bin Zhang, Yi‐Wei Xiong, Yong‐Xu Zhao, Meng‐Ge Zheng, Xia‐Li Huang, Fang Huang, Xing‐Xing Wu, Xue Li, Wei‐Jiao Fan, Lin Hu, Yuan‐Yuan Zeng, Xia‐Ju Cheng, Ji‐Cheng Yue, Juan‐Juan Du, Nan‐Nan Chen, Wen‐Xiang Wei, Qing‐Hua Yao, Xiao‐mei Lu, Chao Huang, Jiong Deng, Zhi‐Jie Chang, He‐Bin Liu, Ting C. Zhao, Y. Eugene Chinn   +24 more
doaj   +1 more source

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. [PDF]

, 2017
SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane ...
Bufalieri, Francesca, Canettieri, Gianluca, Capalbo, Carlo, Coni, Sonia, DE SMAELE, Enrico, Di Magno, L, DI MARCOTULLIO, Lucia, Ferretti, Elisabetta, Kusio Kobialka, M, Mai, Antonello, Mancuso, ANNA BARBARA, Manni, Simona, Niewiadomski, P, Petroni, Marialaura, Rotili, Dante, Screpanti, Isabella, Sdruscia, Giulia, Serrao, SILVIA MARIA, Spiombi, Eleonora   +18 more
core   +2 more sources

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

Cysteine S-acetylation is a widespread post-translational modification on metabolic proteins

npj Metabolic Health and Disease
Protein acetylation is a fundamental regulatory mechanism occurring primarily on lysine amino acids. Here we report systematic in vivo characterization of cysteine S-acetylation as a widespread post-translational modification in mammalian tissues.
E. Keith Keenan, Akshay Bareja, Yannie Lam, Paul A. Grimsrud, Matthew D. Hirschey   +4 more
doaj   +1 more source

Omics assisted N-terminal proteoform and protein expression profiling on methionine aminopeptidase 1 (MetAP1) deletion [PDF]

, 2018
Excision of the N-terminal initiator methionine (iMet) residue from nascent peptide chains is an essential and omnipresent protein modification carried out by methionine aminopeptidases (MetAPs) that accounts for a major source of N-terminal proteoform ...
Fijalkowska, Daria, Jonckheere, Veronique, Van Damme, Petra   +2 more
core   +1 more source

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Advanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan, Kenny Man, Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj   +9 more
wiley   +1 more source

Separase prevents genomic instability by controlling replication fork speed [PDF]

, 2016
Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco, Palumbo, Elisa, Camerini, Serena, D'Alessio, Barbara, Quarantotti, Valentina, Casella, Maria Luisa, Rizzo, Ilaria Maria, Cukrov, Dubravka, Delia, Domenico, Russo, Antonella, Crescenzi, Marco, Musio, Antonio   +11 more
core   +4 more sources