Results 71 to 80 of about 230,380 (304)

The deacetylase HDAC6 is an essential component of stress granules and plays a critical role in the cellular response to stress [PDF]

, 2007
The reversible acetylation of histones has a critical role in transcriptional regulation. Likewise reversible acetylation of non-histones proteins is also important for other cellular processes.
Kwon, So Hee
core   +1 more source

Solid‐State Nanopore Characterization of Dendrimer‐Peptide Conjugates Across Defined Peptide Loadings

Advanced Materials Interfaces, EarlyView.
Solid‐state nanopores are used to interrogate dendrimer‐peptide conjugates with systematically varied peptide loading. Single‐particle ionic current signatures reveal how ligand density modulates deformability, transport pathways, and electromechanical coupling during translocation.
Chaoming Gu, Jin Woong Lee, Kamruzzaman Joty, Marisela Leon, Santosh Khatri, Janeesha Manawasinghe, Seungpyo Hong, Min Jun Kim   +7 more
wiley   +1 more source

Proline cis-trans isomerization is influenced by local lysine acetylation-deacetylation

, 2014
Acetylation of lysine residues has several characterised functions in chromatin. These include neutralization of the lysine’s positive charge to directly influence histone tail-DNA/internucleosomal interactions or indirect effects via bromodomain ...
Jane Mellor, Françoise S. Howe
core   +1 more source

Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

Cell Reports, 2019
Summary: Neuronal activity-inducible gene transcription correlates with rapid and transient increases in histone acetylation at promoters and enhancers of activity-regulated genes.
Liang-Fu Chen, Yen Ting Lin, David A. Gallegos, Mariah F. Hazlett, Mariana Gómez-Schiavon, Marty G. Yang, Breanna Kalmeta, Allen S. Zhou, Liad Holtzman, Charles A. Gersbach, Jörg Grandl, Nicolas E. Buchler, Anne E. West   +12 more
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast. [PDF]

, 2010
Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function.
Mulvihill, Daniel P., Arthur T. Coulton, East, Daniel A., Coulton, Arthur T., Lehman, William, William Lehman, Daniel A. East, Daniel P. Mulvihill, Galinska-Rakoczy, Agnieszka, Agnieszka Galinska-Rakoczy   +9 more
core   +1 more source

Matrix stiffness‐induced α‐tubulin acetylation is required for skin fibrosis formation through activation of Yes‐associated protein

MedComm, 2023
Skin fibrosis, a pathological process featured by fibroblast activation and extracellular matrix (ECM) deposition, makes a significant contribution to morbidity.
Dongsheng Wen, Ya Gao, Yangdan Liu, Chiakang Ho, Jiaming Sun, Lu Huang, Yuxin Liu, Qingfeng Li, Yifan Zhang   +8 more
doaj   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Microtubule acetylation is not required for HIV-1 infection or TRIM69-mediated restriction of HIV-1 infection

Journal of Virology
Microtubule acetylation, a post-translational modification catalyzing the addition of acetyl groups to lysine residues on alpha tubulin, confers mechanical resilience to microtubules and influences intracellular cargo transport.
Drew M. Lichon, Natalie J. LoMascolo, Bryan C. Mounce, Edward M. Campbell   +3 more
doaj   +1 more source

The Epigenetic Landscape of Pancreatic Cancer Stem Cells

Epigenomes, 2018
Data now indicates that in addition to genetic alterations/mutations, human cancer cells exhibit important changes in their epigenome. In the context of this review, we define the epigenome as the chemical compounds and/or proteins that can interact with
Sladjana Zagorac, Laura Garcia-Bermejo, Bruno Sainz   +2 more
doaj   +1 more source