Results 61 to 70 of about 374,029 (398)
Plant responses to abiotic stress: the chromatin context of transcriptional regulation [PDF]
, 2017 The ability of plants to cope with abiotic environmental stresses such as drought, salinity, heat, cold or flooding relies on flexible mechanisms for re-programming gene expression. Over recent years it has become apparent that transcriptional regulation
Amtmann, Anna +2 more
core +1 more source
Ancient Regulatory Role of Lysine Acetylation in Central Metabolism
mBio, 2017 Lysine acetylation is a common protein post-translational modification in bacteria and eukaryotes. Unlike phosphorylation, whose functional role in signaling has been established, it is unclear what regulatory mechanism acetylation plays and whether it ...
Ernesto S. Nakayasu +14 more
doaj +1 more source
Regulation of Cellular Metabolism by Protein Lysine Acetylation
Science, 2010 Metabolic Regulation Through Acetylation Covalent modification of lysine residues in various proteins in the nucleus is a recognized mechanism for control of transcription.
Shimin Zhao +21 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
2H-NMR studies of supercooled and glassy aspirin [PDF]
Journal of Non-Crystalline Solids, 353, 3788 (2007), 2007 Acetyl salicylic acid, deuterated at the methyl group, was investigated using 2H-NMR in its supercooled and glassy states. Just above the glass transition temperature the molecular reorientations were studied using stimulated-echo spectroscopy and demonstrated a large degree of similarity with other glass formers.
arxiv +1 more source
Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line [PDF]
, 2010 Butyrate, a known histone deacetylase inhibitor (HDACi) and product of fibre fermentation, is postulated to mediate the protective effect of dietary fibre against colon cancer.
Benson, R.S.P. +6 more
core +4 more sources
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases
Stem Cells International, 2021 As the earliest studied epigenetic modification, acetylation has been explored a lot through the years. While bone tissue acts as an indispensable part of body, researches aimed at the relationship between the bone and acetylation became necessary.
Qinglu Tian +4 more
doaj +1 more source
Essays in Biochemistry, 2019 Packaging the long and fragile genomes of eukaryotic species into nucleosomes is all well and good, but how do cells gain access to the DNA again after it has been bundled away? The solution, in every species from yeast to man, is to post-translationally
Claire E Barnes +2 more
semanticscholar +1 more source
Experimental and Therapeutic Medicine, 2020 Cells primarily rely on proteins to perform the majority of their physiological functions, and the function of proteins is regulated by post-translational modifications (PTMs).
Can Xia +4 more
semanticscholar +1 more source