Results 61 to 70 of about 199,012 (297)

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity

Advanced Functional Materials, EarlyView.
A synthetic DNA‐crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct timescales of mechano‐sensing that regulate cell behavior.
Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg   +4 more
wiley   +1 more source

Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity.

PLoS Genetics
Proteostasis, the maintenance of cellular protein balance, is essential for cell viability and is highly conserved across all organisms. Newly synthesized proteins, or "clients," undergo sequential processing by Hsp40, Hsp70, and Hsp90 chaperones to ...
Siddhi Omkar, Megan M Mitchem, Joel R Hoskins, Courtney Shrader, Jake T Kline, Nitika, Luca Fornelli, Sue Wickner, Andrew W Truman   +8 more
doaj   +1 more source

Acetyl-CoA Carboxylase Regulates Global Histone Acetylation [PDF]

Journal of Biological Chemistry, 2012
Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation and synthesis of fatty acids compete for the same acetyl-CoA pool.
Luciano Galdieri, Ales Vancura
openaire   +3 more sources

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription

Nature Communications
In all eukaryotes, acetylation of histone lysine residues correlates with transcription activation. Whether histone acetylation is a cause or consequence of transcription is debated.
Tim Liebner, Sinan Kilic, Jonas Walter, Hitoshi Aibara, Takeo Narita, Chunaram Choudhary   +5 more
doaj   +1 more source

Transcription factor competition regulates lysosomal biogenesis and autophagy

Molecular & Cellular Oncology, 2020
“In the field of observation, chance favours only the prepared mind” (Louis Pasteur). This motto seems to have guided our unexpected results published recently in Nature Communications, where we describe an epigenetic rheostat that regulates expression ...
Alessandra d'Azzo, Ida Annunziata
doaj   +1 more source

S-N Transfer and Dual Acetylation in the S-Acetylation and N-Acetylation of 3-Phosphoglyceraldehyde Dehydrogenase by Substrates

Journal of Biological Chemistry, 1966
Acetyl phosphate or p-nitrophenyl acetate acetylates a specific cysteine residue in 3-phosphoglyceraldehyde dehydrogenase to give an active acetyl-enzyme compound. By raising the pH above 7.0, the acetyl group migrates to the e-amino group of a lysine residue to form an enzymatically inactive compound.
C.F. Agnello, Elizabeth Mathew, Jane Harting Park   +2 more
openaire   +3 more sources

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration

Advanced Healthcare Materials, EarlyView.
Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan   +9 more
wiley   +1 more source

The Contribution and Therapeutic Potential of Epigenetic Modifications in Alzheimer’s Disease

Frontiers in Neuroscience, 2018
Alzheimer’s disease is a progressive neurodegenerative disorder, affecting 50 million people worldwide, for which there is no cure, or effective treatment. Individuals suffering from Alzheimer’s show a decline in cognition over time beginning with memory
Ian C. Wood
doaj   +1 more source

Acetyl Content of Marinobufagin, Arenobufagin and Acetyl-marinobufagin [PDF]

Nature, 1940
FOR marinobufagin, first isolated by Abel and Maeht1 from Bufo marinus and afterwards by Deulofeu and Mendive2 from B. paracnemis, Slotta and Neisser3 suggested the formula C27H38O6, at variance with C24H32O5 accepted by Jensen in many of his papers. They supposed that mar inobuf agin could contain one propionyl group.
E. Duperat, R. Labriola, V. Deulofeu
openaire   +2 more sources