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Structure and gating mechanism of the α7 nicotinic acetylcholine receptor
Cell, 2021 The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a homopentamer, is exceptionally permeable to Ca2+, and desensitizes faster
Anant Gharpure +2 more
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Dopamine and glutamate regulate striatal acetylcholine in decision-making
Nature, 2023 Experiments in mice provide insight into the dynamic relationship between dopamine and acetylcholine in the ventrolateral striatum and how this signalling circuit affects decision-making and behaviour.
Celia Beron +2 more
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Structure and dynamics of the M3 muscarinic acetylcholine receptor
Nature, 2012 Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (
Andrew C Kruse +2 more
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British Journal of Pharmacology, 2006 This article traces the development of knowledge about the physiology and pharmacology of acetylcholine and its receptors between 1930 and 2005, with emphasis on contributions by members of the British Pharmacological Society, and by other British pharmacologists and physiologists.British Journal of Pharmacology(2006)147, S120–S126.
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Muscarinic acetylcholine receptors: novel opportunities for drug development
Nature Reviews Drug Discovery, 2014 Andrew C Kruse +2 more
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Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum
Frontiers in Endocrinology, 2023 In vertebrates, gonadotropin-releasing hormone (GnRH)-secreting neurons control fertility by regulating gonadotrophs in the anterior pituitary. While it is known that acetylcholine (ACh) influences GnRH secretion, whether the effect is direct or indirect,
David M. Shostak +3 more
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Cells, 2023 Major features of aging might be progressive decreases in cognitive function and physical activity, in addition to withered appearance. Previously, we reported that the intracerebroventricular injection of human neural stem cells (NSCs named F3) encoded ...
Jangbeen Kyung +7 more
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WormBook, 2007 Acetylcholine is the major excitatory neurotransmitter at nematode neuromuscular junctions, and more than a third of the cells in the C. elegans nervous system release acetylcholine. Through a combination of forward genetics, drug-resistance selections, and genomic analysis, mutants have been identified for all of the steps specifically required for ...
openaire +3 more sources
Lipid Membrane State Change by Catalytic Protonation and the Implications for Synaptic Transmission
Membranes, 2021 In cholinergic synapses, the neurotransmitter acetylcholine (ACh) is rapidly hydrolyzed by esterases to choline and acetic acid (AH). It is believed that this reaction serves the purpose of deactivating ACh once it has exerted its effect on a receptor ...
Christian Fillafer +2 more
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Chemosensors, 2022 A study of the transient potential signals obtained with a cation-selective electrode based on an ion-exchanger was carried out for solutions of the following individual cations at different concentrations: H+, Li+, Na+, K+, Rb+, Mg2+, Ca2+, choline (Ch+)
José Antonio González-Franco +2 more
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