Results 1 to 10 of about 288,335 (198)
Dopamine and glutamate regulate striatal acetylcholine in decision-making
Nature, 2023 Experiments in mice provide insight into the dynamic relationship between dopamine and acetylcholine in the ventrolateral striatum and how this signalling circuit affects decision-making and behaviour.
Lynne Chantranupong +5 more
semanticscholar +1 more source
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor
Cell, 2021 Summary The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and in the cholinergic inflammatory pathway.
C. Noviello +7 more
semanticscholar +1 more source
Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum
Frontiers in Endocrinology, 2023 In vertebrates, gonadotropin-releasing hormone (GnRH)-secreting neurons control fertility by regulating gonadotrophs in the anterior pituitary. While it is known that acetylcholine (ACh) influences GnRH secretion, whether the effect is direct or indirect,
David M. Shostak +3 more
doaj +1 more source
Cells, 2023 Major features of aging might be progressive decreases in cognitive function and physical activity, in addition to withered appearance. Previously, we reported that the intracerebroventricular injection of human neural stem cells (NSCs named F3) encoded ...
Jangbeen Kyung +7 more
doaj +1 more source
WormBook, 2007 Acetylcholine is the major excitatory neurotransmitter at nematode neuromuscular junctions, and more than a third of the cells in the C. elegans nervous system release acetylcholine. Through a combination of forward genetics, drug-resistance selections, and genomic analysis, mutants have been identified for all of the steps specifically required for ...
openaire +3 more sources
Lipid Membrane State Change by Catalytic Protonation and the Implications for Synaptic Transmission
Membranes, 2021 In cholinergic synapses, the neurotransmitter acetylcholine (ACh) is rapidly hydrolyzed by esterases to choline and acetic acid (AH). It is believed that this reaction serves the purpose of deactivating ACh once it has exerted its effect on a receptor ...
Christian Fillafer +2 more
doaj +1 more source
Chemosensors, 2022 A study of the transient potential signals obtained with a cation-selective electrode based on an ion-exchanger was carried out for solutions of the following individual cations at different concentrations: H+, Li+, Na+, K+, Rb+, Mg2+, Ca2+, choline (Ch+)
José Antonio González-Franco +2 more
doaj +1 more source
Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’s Diseases [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, with an increasing prevalence rate, mostly related to cholinergic system.
Farnoosh Berahmand +3 more
doaj +1 more source
An optimized acetylcholine sensor for monitoring in vivo cholinergic activity
Nature Methods, 2020 The ability to directly measure acetylcholine (ACh) release is an essential step toward understanding its physiological function. Here we optimized the GRABACh (GPCR-activation-based ACh) sensor to achieve substantially improved sensitivity in ACh ...
Miao Jing +23 more
semanticscholar +1 more source
Acetylcholine and attention [PDF]
Behavioural Brain Research, 2011 Historically, ACh has been implicated in learning and short-term memory functions. However, more recent studies have provided support for a role of cortical ACh in attentional effort, orienting and the detection of behavioral significant stimuli. The current review article summarizes studies in animals and humans which have investigated the role of ACh
Klinkenberg, I. +2 more
openaire +3 more sources