Results 91 to 100 of about 185,010 (296)

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain

open access: yesCell Reports, 2017
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine.
Jose A. Matta   +6 more
doaj   +1 more source

The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection

open access: yesBioEssays, EarlyView.
Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi   +2 more
wiley   +1 more source

Larvicidal Activity of Phytochemicals From Handroanthus impetiginosus Seeds Against Culex quinquefasciatus

open access: yesChemistry &Biodiversity, EarlyView.
The hexane extract was obtained from the seeds of H. impetiginosus, from which fatty acids and FAMEs were obtained. The three samples were tested on C. quinquefasciatus larvae, promoting mortality with moderate LC50 values. The hexane extract was analyzed by gas chromatographymass spectrometry (GC‐MS), and the most abundant compounds were ethyl oleate (
Luana Cristina Diniz Santos   +6 more
wiley   +1 more source

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

open access: yesChemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo   +3 more
wiley   +1 more source

Clinical and neurophysiological characteristics of heterozygous NPC1 carriers

open access: yesJIMD Reports, 2019
Niemann‐Pick disease type C (NPC) is an uncommon lysosomal storage disorder, which is characterized neuropathologically by cholinergic dysfunction and presents clinically with a broad series of neurological signs and symptoms.
Alberto Benussi   +10 more
doaj   +1 more source

Associations Between Nicotine Metabolites and Serum Neurofilament Light Chain Levels in the General Population

open access: yesChronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Nicotine has been associated with cognitive functions such as memory and attention, with serum neurofilament light chain (sNfL) as a biomarker for neurological diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS).
Qianqian Ji   +5 more
wiley   +1 more source

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