Results 91 to 100 of about 321,644 (366)

A factor graph EM algorithm for inference of kinetic microstates from patch clamp measurements [PDF]

arXiv, 2021
We derive a factor graph EM (FGEM) algorithm, a technique that permits combined parameter estimation and statistical inference, to determine hidden kinetic microstates from patch clamp measurements. Using the cystic fibrosis transmembrane conductance regulator (CFTR) and nicotinic acetylcholine receptor (nAChR) as examples, we perform {\em Monte Carlo}
arxiv  

Scanning curves and kinetics of the acetylcholine / acetylcholine receptor hysteresis [PDF]

Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1988
The high affinity binding of the neurotransmitter acetylcholine (AcCh) to the nicotinic acetylcholine receptor (nAcChR) of the electric organ of Torpedo californica exhibits a pronounced hysteresis and scanning loops. Dialysis conditions lead to an equilibrium binding curve which is coincident with the upper hysteresis branch; K = 5 × 10−9M, 4° C; and ...
Neumann, Eberhard, Boldt, Elvira, Rauer, Barbara, Wolf, Hendrik, Chang, Hai Won   +4 more
openaire   +3 more sources

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. [PDF]

, 2015
Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits.
D'Oyley, JM, Dhankher, P, Gill-Thind, JK, Millar, NS, Sheppard, TD   +4 more
core  

Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]

, 2006
It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Broide R.S., Damsma G., Dere E., Dingledine R., Finlay J.M., Gothert M., Kadotani H., Miyamoto Y., Potter P.E., Sabatino M., Schlett K., Sethy V.M.   +11 more
core   +2 more sources

Wearable Systems of Reconfigurable Microneedle Electrode Array for Subcutaneous Multiplexed Recording of Myoelectric and Electrochemical Signals

Advanced Science, EarlyView.
A reconfigurable microneedle electrode array integrated system is developed for minimally invasive and transdermal monitoring of subcutaneous electromyography, reactive oxygen species, and pH values. By assembling discrete thumbtack‐shaped microneedles into an array, the system enables multi‐parameter detection with single‐microneedle resolution.
Zhengjie Liu, Chuanjie Yao, Xingyuan Xu, Xinshuo Huang, Shuang Huang, Shantao Zheng, Tao Zhang, Yan Li, Fanmao Liu, Yuxiang Wu, Jing Liu, Hui‐jiuan Chen, Xi Xie   +12 more
wiley   +1 more source

Simultaneous Electrophysiology and Fiber Photometry in Freely Behaving Mice

Frontiers in Neuroscience, 2020
In vivo electrophysiology is the gold standard technique used to investigate sub-second neural dynamics in freely behaving animals. However, monitoring cell-type-specific population activity is not a trivial task.
Amisha A. Patel, Niall McAlinden, Keith Mathieson, Shuzo Sakata   +3 more
doaj   +1 more source

Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen [PDF]

, 2002
The weakness in myasthenia gravis (MG) is mediated by autoantibodies against adult muscle acetylcholine receptors (AChR) at the neuromuscular junction; most of these antibodies also bind to fetal AChR, which is present in the thymus.
Beeson, D., Ledwidge, S., Matthews, I., Sims, G., Stott, D.I., Vincent, A., Wilcox, N.   +6 more
core   +1 more source

Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, EarlyView.
This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng, Ruizeng Luo, Ying Chen, Xiaoqiang Liu, Yuanyin Xi, Muhammad Usman, Xupin Jiang, Zhou Li, Jiaping Zhang   +8 more
wiley   +1 more source

Functional activity of peptide ion channels in tethered bilayer lipid membranes: Review

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Ion transport across biomembranes plays a major role in living cells. This fundamental function is normally carried out by molecules with both a hydrophobic and a hydrophilic side (amphiphilic molecules), which aggregate within the membrane forming a hydrophilic pore (the ion channel) permitting the selective translocation of permeant ions ...
Rolando Guidelli, Lucia Becucci
wiley   +1 more source

Gastroprotective effects of methanol extract of Eremomastax speciosa leaf harvested in Southern part of Nigeria in rat

The EuroBiotech Journal, 2018
Gastric ulcer is one of the common cause of hospital consultation with an increasing prevalence worldwide and it is traditionally managed with herbal medicine in the developing countries.
Onoja Samuel O., Chinagorom Osborn, Ikpa Chinyere B. C., Madubuike Kelechi G., Ezeigbo Ihechiluru I., Ijioma Solomon N., Anaga Aruh O., Ezeja Maxwell I.   +7 more
doaj   +1 more source