Results 101 to 110 of about 221,231 (306)

Simultaneous Electrophysiology and Fiber Photometry in Freely Behaving Mice

Frontiers in Neuroscience, 2020
In vivo electrophysiology is the gold standard technique used to investigate sub-second neural dynamics in freely behaving animals. However, monitoring cell-type-specific population activity is not a trivial task.
Amisha A. Patel, Niall McAlinden, Keith Mathieson, Shuzo Sakata   +3 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo

eLife, 2018
The cholinergic interneurons (CINs) of the striatum are crucial for normal motor and behavioral functions of the basal ganglia. Striatal CINs exhibit tonic firing punctuated by distinct pauses.
Stefano Zucca, Aya Zucca, Takashi Nakano, Sho Aoki, Jeffery Wickens   +4 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix. [PDF]

, 1995
Agrin is an extracellular matrix (ECM) protein with a calculated relative molecular mass of more than 200 kD that induces the aggregation of acetylcholine receptors (AChRs) at the neuromuscular junction. This activity has been mapped to its COOH terminus.
Ruegg, M. A., A J Denzer, B Schumacher, Denzer, A J, M A Ruegg, Gesemann, M., Schumacher, B, M Gesemann, Schumacher, B., Gesemann, M, Ruegg, M A, Denzer, A. J.   +11 more
core   +1 more source

Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva

eLife, 2017
Ciliated surfaces harbouring synchronously beating cilia can generate fluid flow or drive locomotion. In ciliary swimmers, ciliary beating, arrests, and changes in beat frequency are often coordinated across extended or discontinuous surfaces.
Csaba Verasztó, Nobuo Ueda, Luis A Bezares-Calderón, Aurora Panzera, Elizabeth A Williams, Réza Shahidi, Gáspár Jékely   +6 more
doaj   +1 more source

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Kellner, Julia, Tantzscher, Juliane, Edelmann, Martin, Bergner, Albrecht, Oelmez, Hamza, Huber, Rudolf M., Fischer, Rainald   +6 more
core   +1 more source

Acetylcholine-treated murine dendritic cells promote inflammatory lung injury

, 2019
In recent years a non-neuronal cholinergic system has been described in immune cells, which is often usually activated during the course of inflammatory processes. To date, it is known that Acetylcholine (ACh), a neurotransmitter extensively expressed in
Mariela A Moreno Ayala, Marianela Candolfi, Mónica Vermeulen, Marianela Candolfi (44862), Silvia Vanzulli, Mariela A. Moreno Ayala (6416255), Gabriela Salamone, Jorge Geffner (293076), Julieta Alcain (6416249), Silvia Vanzulli (6416252), Soledad Gori, Gabriela Salamone (566964), Soledad Gori (6416246), Mónica Vermeulen (367129), Carolina Jancic (337983), Carolina Jancic, Jorge Geffner, Julieta Alcain   +17 more
core   +1 more source

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure [PDF]

, 2012
Background: Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking ...
Timpson, NJ, Upton, Mark N, Johnstone, Elaine, Vineis, Paolo, Morris, Richard W, Johnson, Paul C. D., Johnson, P.C.D., Uhl, GR, Amuzu, A., Aveyard, P., Munafò, Marcus R., Sattar, N, Watt, G., Walther, Donna, Ebrahim, S, Timofeeva, M.N., Hingorani, AD, Upton, M.N., Morris, Richard W., Johnson, PC, Riboli, E., Munafò, Marcus R, Watt, Graham, Ebrahim, Shah, Relton, C., Jefferis, BJ, Timofeeva, Maria N., Casas, Juan P., Riboli, E, Riboli, Elio, Padmanabhan, S., Palmer, T.M., Prieto-Merino, D, Jefferis, Barbara J., Vineis, P., Munafo, M.R., Amuzu, Antoinette, Prieto-Merino, D., ?, ?, Brennan, P., Hingorani, Aroon D, Padmanabhan, Sandosh, Uhl, G.R., Morris, RW, Uhl, George R, Prieto-Merino, David, Johnson, Paul CD, Timpson, Nicholas J., Whincup, PH, Whincup, P.H., Palmer, Tom M, Johnstone, E.C., Sattar, N., Johnstone, Elaine C., Johnson, Paul C D, Hingorani, A.D., Jefferis, B.J., Brennan, P, Upton, Mark N., Davey Smith, George, Upton, MN, EPIC Study Group, Ebrahim, S., Davey Smith, G, Jefferis, Barbara J, Whincup, Peter H, Uhl, George R., Timofeeva, MN, Timofeeva, Maria N, Aveyard, P, Timpson, Nicholas J, Relton, Caroline, Sattar, Naveed, Casas, Juan P, Amuzu, A, Brennan, Paul, Munafò, MR, Palmer, TM, Relton, C, Walther, D., Vineis, P, Timpson, N.J., Watt, G, Hingorani, Aroon D., Casas, JP, Johnstone, Elaine C, Padmanabhan, S, Casas, J.P., Davey Smith, G., Palmer, Tom M., Johnstone, EC, Walther, D, Whincup, Peter H., Morris, R.W., Aveyard, Paul   +94 more
core   +1 more source

Philanthotoxin analogues that selectively inhibit ganglionic nicotinic acetylcholine receptors with exceptional potency [PDF]

, 2019
Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 non-selectively inhibits several excitatory ligand-gated ion channels, and we recently showed that its synthetic analogue ...
Kachel, Hamid S., Mellor, Ian R., Franzyk, Henrik   +2 more
core   +1 more source