Results 121 to 130 of about 180,246 (294)

Acetylcholine metabolism in the central nervous system [PDF]

, 1939
P. J. Mann, Michael Tennenbaum, J. H. Quastel   +2 more
openalex   +1 more source

A Scalable L‐α‐Glycerophosphorylcholine Synthesis through the Automatic pH‐Controlled (R)‐Glycidol Ring Opening with Phosphorylcholine

Chemistry–Methods, EarlyView.
Automatic titrator enables the regioselective ring opening of (R)‐glycidol in water in the presence of phosphorylcholine, leading to the synthesis of L‐α‐glycerophosphorylcholine, a commercially available drug, in very high yield. The reaction is triggered by a minimum amount of NaOH and reactants, while the optimal pH is precisely regulated through ...
Antonio Massa, Mauro Anibaldi, Lorenzo De Ferra   +2 more
wiley   +1 more source

Bioequivalence of a Donepezil/Memantine 10/20 mg Fixed‐Dose Combination Versus Single‐Component Tablets in Healthy Korean Males

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi, Byung Hak Jin, Do Hoon Keum, Kyoung Hoon Mo, Min Soo Park, Juhwan Lee, Sungjin Park, Choon Ok Kim   +7 more
wiley   +1 more source

Population Pharmacokinetic and Exposure‐Response Analysis of the Cognitive Effects of TAK‐071 in Participants With Parkinson Disease and Cognitive Impairment

Clinical Pharmacology in Drug Development, EarlyView.
Abstract TAK‐071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK‐071 following single (1‐160 mg) and multiple (3‐15 mg once daily) oral‐dose TAK‐071 in 112 healthy participants ...
Hongxia Jia, Axel Facius, Rachel Jennings, Yaming Hang, Jaya Padmanabhan, Niraj M. Shanbhag, Brian T. Harel, Arthur Simen, Wei Yin   +8 more
wiley   +1 more source

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

, 1957
B. Katz, S. Thesleff
openalex   +1 more source

The effects of acetylcholine and other drugs on the isolated superior cervical ganglion [PDF]

, 1956
Judith Pascoe
openalex   +1 more source

Toxicity Assessment and Bioremediation of Deep Eutectic Solvents by Haloferax mediterranei: A Step toward Sustainable Circular Chemistry

ChemSusChem, EarlyView.
The toxicity and biodegradability of deep eutectic solvents (DESs) can be evaluated using Haloferax mediterranei as a novel model organism. The haloarchaeon metabolizes specific DES components, highlighting its potential for DES bioremediation. These findings support the use of H.
Guillermo Martínez, Gabriela Guillena, Rosa María Martínez‐Espinosa   +2 more
wiley   +1 more source

Release of acetylcholine at voluntary motor nerve endings

, 1936
H. H. Dale, W. Feldberg, Miriam A. Vogt
openalex   +2 more sources

THE ANTAGONISM OF ACETYLCHOLINE AND OF QUATERNARY AMMONIUM SALTS [PDF]

, 1937
A. J. Clark, J. RAVENTÓS
openalex   +1 more source

Effects of Dimenhydrinate on Motor Behavior and Vascular Function: Possible Implications for the Field of Sports

Drug Testing and Analysis, EarlyView.
Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. We observed that the combination of DPH and 8‐Cl‐T was identified as the responsible for increasing blood pressure and heart rate in the biological model used.
Jazmín Flores‐Monroy, Diana Ramírez‐Hernández, Diego Lezama‐Martínez, Benjamín Velasco‐Bejarano   +3 more
wiley   +1 more source