Results 41 to 50 of about 321,644 (366)

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts [PDF]

, 2019
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with saturated ...
Antollini, Silvia Susana, Fabiani, Camila   +1 more
core   +1 more source

Quantification of atropine sulphate monohydrate and obidoxime dichloride in two‐chamber autoinjectors for accessing uniformity of dosage

Analytical Science Advances, Volume 3, Issue 11-12, Page 297-303, December 2022., 2022
Abstract In the treatment of organophosphate poisoning atropine sulphate monohydrate (AT) and obidoxime dichloride (OB) play a vital role. Currently, the Austrian Armed Forces use the DOUBLEPEN OA two‐chamber autoinjector (ChemProtect) to administer these two drugs.
Iva Spreitzer, Paniz Morawej, Richard Wosolsobe, Rainer Stinzl, Judith Wackerlig   +4 more
wiley   +1 more source

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain

Cell Reports, 2017
Neuronal nicotinic acetylcholine receptors (nAChRs) participate in diverse aspects of brain function and mediate behavioral and addictive properties of nicotine.
Jose A. Matta, Shenyan Gu, Weston B. Davini, Brian Lord, Edward R. Siuda, Anthony W. Harrington, David S. Bredt   +6 more
doaj   +1 more source

Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors

Frontiers in Neuroscience, 2023
IntroductionRepeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, the mechanisms underlying these effects have not yet been fully understood.
Justine Blin, Justine Blin, Camille Gautier, Philippe Aubert, Tony Durand, Thibauld Oullier, Laetitia Aymeric, Laetitia Aymeric, Philippe Naveilhan, Damien Masson, Damien Masson, Michel Neunlist, Kalyane Bach-Ngohou, Kalyane Bach-Ngohou   +13 more
doaj   +1 more source

On the excitation of action potentials by protons and its potential implications for cholinergic transmission [PDF]

, 2014
One of the most conserved mechanisms for transmission of a nerve pulse across a synapse relies on acetylcholine. Ever since the Nobel-prize winning works of Dale and Loewi, it has been assumed that acetylcholine - subsequent to its action on a postsynaptic cell - is split into inactive by-products by acetylcholinesterase.
arxiv   +1 more source

Functional characterisation of a nicotinic acetylcholine receptor alpha subunit from the brown dog tick, Rhipicephalus sanguineus [PDF]

, 2014
Open Access funded by Biotechnology and Biological Sciences Research Council Under a Creative Commons license This work was supported by a Biotechnology and Biological Sciences Research Council (UK) Industrial CASE studentship award (BBSSM200411428) to K.
Alan S. Bowman, Aljamali, Anatriello, Anderson, Andrew K. Jones, Baines, Ball, Bass, Bennett, Bertrand, Bissinger, Blagburn, Blake, Bowman, Breer, Buckingham, Buckingham, Chmelar, David B. Sattelle, Debra J. Woods, Dederer, Dederer, Dermauw, Erdmanis, Gao, Geng, George, Gray, Grbic, Halevi, Halevi, Hedges, Hermsen, Hosie, Hsu, Huang, Inokuma, Jeschke, Jeyaprakash, Jones, Jongejan, Kao, Karim, Kazuhiko Matsuda, Kristin Lees, Kumar, Lansdell, Lansdell, Lansdell, Lees, Lees, Liu, Lupu-Meiri, Marshall, Meinke, Miki Akamatsu, Miller, Mounsey, Nauen, Nene, Perry, Roma, Salgado, Simo, Sonenshine, Song, Tang, Taylor, Turberg, Watson, Woods, Yao, Zheng   +72 more
core   +3 more sources

The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test

Biomedical Papers, 2015
Aims: The number of approved drugs for the clinical treatment of Alzheimer disease remains limited. For this reason, there is extensive search for novel therapies.
Jan Misik, Jan Korabecny, Eugenie Nepovimova, Pavla Cabelova, Jiri Kassa   +4 more
doaj   +1 more source

Impaired muscarinic modulation of the rat prelimbic cortex in neuropathic pain is sexually dimorphic and associated with cold allodynia

Frontiers in Cellular Neuroscience, 2023
Cholinergic modulation of the brain cortex is critical for cognitive processes, and altered cholinergic modulation of the prefrontal cortex is emerging as an important mechanism of neuropathic pain.
Taylor Jefferson, Haram R. Kim, Marco Martina   +2 more
doaj   +1 more source

Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin [PDF]

Front. Immunol. 2019, 2018
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes
arxiv   +1 more source

Commentary: Nicotinic acetylcholine receptor α9 and α10 subunits are expressed in the brain of mice [PDF]

, 2018
Fil: Morley, Barbara J.. Boys Town National Research Hospita; Estados UnidosFil: Whiteaker, Paul. Barrow Neurological Institute; Estados UnidosFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas.
Elgoyhen, Ana Belen, Morley, Barbara J., Whiteaker, Paul   +2 more
core   +1 more source