Results 61 to 70 of about 185,010 (296)

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Gastrin‐Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus

Pharmacology Research & Perspectives
Gastrin‐releasing peptide (GRP) and neuromedin B (NMB) are found in the stomach's myenteric plexus and muscular layers. When exogenously administered, they contract stomach muscle in several species, but their ability to modulate enteric nerve functions ...
Diego Currò, Raj Makwana, Gareth J. Sanger   +2 more
doaj   +1 more source

Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis

Advanced Science, EarlyView.
Sleep deprivation (SD) exacerbates ligature‐induced periodontitis (LIP) through the trigeminal nerve‐periodontal neuroimmune pathway mediated by the acetylcholinesterase (AChE)‐acetylcholine (ACh)‐α7 nicotinic receptor (α7nAChR) axis. While electroacupuncture (EA) alleviates the condition of LIP combined with SD by activating the α7nAChR.
Kehao Liu, Qi Huang, Mingcong Yang, Ziyu Huang, Kamoran Tuerhong, Yue Zu, Ying Xie, Xuehui Hu, Qianyu Zhang, Ping He, Nannan Huang, Rong Zhang, Yuzhou Li, Sheng Yang   +13 more
wiley   +1 more source

A neurotropic approach to the treatment of multi-infarct dementia using l-a-glycerylphosphorylcholine

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018
A multicenter, unblinded, randomized, controlled clinical trial was conducted to evaluate the efficacy and tolerability of L-aglycerylphosphorylcholine (L-a-GPC) 1 gm/day IM compared with that of cytidine diphosphocholine (CDP-choline) 1 gm/day IM in 112
Alberto Muratorio, Ubaldo Bonuccelli, Angelo Nuti, Noe Bavpistini, Stefano Passero, Vittoria Caruso, Barbara Batani, Alberto Baroni, Federico Mayer, Tiziana Sorbi, Attilio Franciosi, Gianni Moro, Luciano Agostini, Massimo Piccirilli, Diana Scatozza   +14 more
doaj  

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

Advanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li, Maoxiang Xu, Boyu Cai, Xiangyu Li, Zhanping Liang, Xiaohuan Xia, Haitao Zhang, Zhiwen Zhang, Fei Tan, Jialin Charlie Zheng   +9 more
wiley   +1 more source

Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex

Frontiers in Neuroanatomy, 2018
From an anatomical point of view the neocortex is subdivided into up to six layers depending on the cortical area. This subdivision has been described already by Meynert and Brodmann in the late 19/early 20.
Gabriele Radnikow, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +3 more
doaj   +1 more source

Single‐Cell Immune Profiling Reveals Neutrophils Promote Myasthenia Gravis Exacerbation Through BAFF Secretion

Advanced Science, EarlyView.
Single‐cell transcriptomics and clinical data show that during myasthenia gravis (MG) exacerbation, bone marrow mature neutrophils expand and enter blood, with parallel increase of B‐cell activating factor (BAFF)–positive neutrophils. Experimental autoimmune myasthenia gravis (EAMG) confirms a pathogenic interferon‐γ (IFN‐γ)–neutrophil–BAFF axis ...
Zhaoxu Zhang, Jingya Dong, Mengyuan Qiu, Jie Bai, Xufeng Cheng, Xiaodong Song   +5 more
wiley   +1 more source

Inhibitory Effect of Ginkgo Biloba Extract on the Tonus of the Small Intestine and the Colon of Rabbits

Molecules, 2010
Ginkgo biloba is widely used in folk medicine. Patients very often use the plant preparation with no concern for purity. They also tend to increase the dosage by themselves and this may result in certain insufficiently researched acute effects.
Svetlana Trivic, Vesna Ivetic, Mira Popovic, Maja Djurendic Brenesel, Radenkovic Mirjana, Vladimir Pilija   +5 more
doaj   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source