Results 1 to 10 of about 124,177 (265)

Development of a novel alpha7-nicotinic acetylcholine receptor-selective cell-penetrating peptide for intracellular cargo transport. [PDF]

Drug Deliv
Weber L, O'Brien BCV, Weltzin MM.
europepmc   +2 more sources

Cell-Type Specific Neuromodulation of Excitatory and Inhibitory Neurons via Muscarinic Acetylcholine Receptors in Layer 4 of Rat Barrel Cortex

Frontiers in Neural Circuits, 2022
The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties ...
Guanxiao Qi, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +3 more
doaj   +1 more source

Simultaneous Presence of Acetylcholine Receptor and Muscle Specific Tyrosine Kinase Antibodies in Myasthenia Gravis [PDF]

International Journal of Basic Science in Medicine, 2019
Myasthenia gravis (MG) is known as an autoimmune disorder which affects transmission in neuromuscular junction. The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies.
Maryam Poursadeghfard, Sara Azhdari
doaj   +1 more source

Exploring Cholinergic Compounds for Peripheral Neuropathic Pain Management: A Comprehensive Scoping Review of Rodent Model Studies

Pharmaceuticals, 2023
Neuropathic pain affects about 7–8% of the population, and its management still poses challenges with unmet needs. Over the past decades, researchers have explored the cholinergic system (muscarinic and nicotinic acetylcholine receptors: mAChR and nAChR)
Edouard Montigné, David Balayssac
doaj   +1 more source

A potential cost of evolving epibatidine resistance in poison frogs

BMC Biology, 2023
Background Some dendrobatid poison frogs sequester the toxin epibatidine as a defense against predators. We previously identified an amino acid substitution (S108C) at a highly conserved site in a nicotinic acetylcholine receptor β2 subunit of ...
Julia M. York, Cecilia M. Borghese, Andrew A. George, David C. Cannatella, Harold H. Zakon   +4 more
doaj   +1 more source

A novel labeling approach identifies three stability levels of acetylcholine receptors in the mouse neuromuscular junction in vivo. [PDF]

PLoS ONE, 2011
BACKGROUND: The turnover of acetylcholine receptors at the neuromuscular junction is regulated in an activity-dependent manner. Upon denervation and under various other pathological conditions, receptor half-life is decreased.
Siegfried Strack, Yvonne Petersen, Anika Wagner, Ira V Röder, Marina Albrizio, Markus Reischl, Irene U Wacker, Christoph Wilhelm, Rüdiger Rudolf   +8 more
doaj   +1 more source

Modelling organophosphate intoxication in C. elegans highlights nicotinic acetylcholine receptor determinants that mitigate poisoning.

PLoS ONE, 2023
Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the organophosphate paraoxon-ethyl to treat C.
Patricia G Izquierdo, Claude L Charvet, Cedric Neveu, A Christopher Green, John E H Tattersall, Lindy Holden-Dye, Vincent O'Connor   +6 more
doaj   +1 more source

Sequence of age-associated changes to the mouse neuromuscular junction and the protective effects of voluntary exercise. [PDF]

PLoS ONE, 2013
Loss of connections between motor neurons and skeletal muscle fibers contribute to motor impairment in old age, but the sequence of age-associated changes that precede loss of the neuromuscular synapse remains uncertain.
Anson Cheng, Marco Morsch, Yui Murata, Nazanin Ghazanfari, Stephen W Reddel, William D Phillips   +5 more
doaj   +1 more source

The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor

Pharmacological Research, 2023
Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic receptors (nAChRs) were classically identified to mediate synaptic transmission in the nervous system and the neuromuscular junction. The α9 and α10 nAChR subunits were
Ana Belén Elgoyhen
doaj   +1 more source

Anti-Kv1.4 Antibody Without Myasthenia Gravis

JACC: Case Reports, 2023
Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis.
Naoto Kuyama, MD, Seiji Takashio, MD, PhD, Takumi Nagakura, MD, Michie Imamura, MD, Koutaro Takamatsu, MD, PhD, Masafumi Takae, MD, PhD, Kyoko Hirakawa, MD, PhD, Kenshi Yamanaga, MD, PhD, Shinsuke Hanatani, MD, PhD, Eiichiro Yamamoto, MD, PhD, Kenichi Matsushita, MD, PhD, Mitsuharu Ueda, MD, PhD, Kenichi Tsujita, MD, PhD   +12 more
doaj   +1 more source