Results 1 to 10 of about 2,483,376 (336)

A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor [PDF]

Physical Biology, 3(2):147-159, 2006, 2005
The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin.
Akabas M H, Allen T W, Allen T W, Amiri S, Anishkin A, Bass R B, Bateman A, Beckstein O, Beckstein O, Beckstein O, Beckstein O, Bertrand D, Berweger C D, Brejc K, Chaikin P M, Changeux J P, Chiu S W, Chung S H, Clamp M, Corringer P J, Corry B, Corry B, Corry B, Darden T, England P M, Filatov G N, Frenkel D, Galzi J L, Galzi J L, Grosman C, Gunthorpe M J, Hess B, Hille B, Horenstein J, Humphrey W, Hung A, Jogini V, Karlin A, Katz B, Kirkwood J G, Kumar S, Kuo A, Labarca C, Lester H A, Lester H A, Lindahl E, Mark S P Sansom, Merritt E A, Miyamoto S, Miyazawa A, Moe P C, Nielsen J E, Oliver Beckstein, Panicker S, Panicker S, Plazas P V, Revah F, Roux B, Roux B, Schmid R, Schneider T D, Smart O S, Spronk S A, Tasneem A, Thompson J D, Tieleman D P, Torrie G M, Unwin N, Unwin N, Unwin N, Unwin N, Unwin N, Unwin N, Unwin N, Valleau J P, van Gunsteren W F, Vriend G, Wang F, White B H, Wilson G G, Wilson G G, Zhou Y   +81 more
arxiv   +3 more sources

Quantitative simulation of endplate currents at neuromuscular junctions based on the reaction of acetylcholine with acetylcholine receptor and acetylcholinesterase [PDF]

, 1979
Two kinetic models are introduced which predict amplitudes and time-courses of endplate currents and miniature endplate currents at neuromuscular junctions, at both normal and acetylcholinesterase-inhibited endplates.
Rosenberry, T.L.
core   +3 more sources

Cell-Type Specific Neuromodulation of Excitatory and Inhibitory Neurons via Muscarinic Acetylcholine Receptors in Layer 4 of Rat Barrel Cortex

Frontiers in Neural Circuits, 2022
The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties ...
Guanxiao Qi, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +3 more
doaj   +1 more source

Exploring Cholinergic Compounds for Peripheral Neuropathic Pain Management: A Comprehensive Scoping Review of Rodent Model Studies

Pharmaceuticals, 2023
Neuropathic pain affects about 7–8% of the population, and its management still poses challenges with unmet needs. Over the past decades, researchers have explored the cholinergic system (muscarinic and nicotinic acetylcholine receptors: mAChR and nAChR)
Edouard Montigné, David Balayssac
doaj   +1 more source

Simultaneous Presence of Acetylcholine Receptor and Muscle Specific Tyrosine Kinase Antibodies in Myasthenia Gravis [PDF]

International Journal of Basic Science in Medicine, 2019
Myasthenia gravis (MG) is known as an autoimmune disorder which affects transmission in neuromuscular junction. The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies.
Maryam Poursadeghfard, Sara Azhdari
doaj   +1 more source

A potential cost of evolving epibatidine resistance in poison frogs

BMC Biology, 2023
Background Some dendrobatid poison frogs sequester the toxin epibatidine as a defense against predators. We previously identified an amino acid substitution (S108C) at a highly conserved site in a nicotinic acetylcholine receptor β2 subunit of ...
Julia M. York, Cecilia M. Borghese, Andrew A. George, David C. Cannatella, Harold H. Zakon   +4 more
doaj   +1 more source

Acetylcholine and Acetylcholine Receptors in Taste Receptor Cells [PDF]

Chemical Senses, 2005
Neuroactive substances play important roles as transmitters and neuromodulators. Although many of these substances and/or their receptors are known to be present in taste receptor cells and nerve fibers innervating taste buds, physiological functions of these substances are not well understood (Nagai et al., 1996).
Weihong Lin, Tatsuya Ogura
openaire   +3 more sources

A novel labeling approach identifies three stability levels of acetylcholine receptors in the mouse neuromuscular junction in vivo. [PDF]

PLoS ONE, 2011
BACKGROUND: The turnover of acetylcholine receptors at the neuromuscular junction is regulated in an activity-dependent manner. Upon denervation and under various other pathological conditions, receptor half-life is decreased.
Siegfried Strack, Yvonne Petersen, Anika Wagner, Ira V Röder, Marina Albrizio, Markus Reischl, Irene U Wacker, Christoph Wilhelm, Rüdiger Rudolf   +8 more
doaj   +1 more source

Nicotinic acetylcholine receptors [PDF]

British Journal of Pharmacology, 2018
This themed section of the British Journal of Pharmacology is the product of a conference that focussed on nicotinic ACh receptors (nAChRs) that was held on the Greek island of Crete from 7 to 11 May 2017. ‘Nicotinic acetylcholine receptors 2017’ was the fourth in a series of triennial international meetings that have provided a regular forum for ...
Wonnacott, S, Bermudez, I, Millar, NS, Tzartos, SJ   +3 more
openaire   +4 more sources

Modelling organophosphate intoxication in C. elegans highlights nicotinic acetylcholine receptor determinants that mitigate poisoning.

PLoS ONE, 2023
Organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. Here, we use the organophosphate paraoxon-ethyl to treat C.
Patricia G Izquierdo, Claude L Charvet, Cedric Neveu, A Christopher Green, John E H Tattersall, Lindy Holden-Dye, Vincent O'Connor   +6 more
doaj   +1 more source