Results 1 to 10 of about 116,282 (198)
Acetylcholine and Acetylcholine Receptors in Taste Receptor Cells [PDF]
Chemical Senses, 2005 Neuroactive substances play important roles as transmitters and neuromodulators. Although many of these substances and/or their receptors are known to be present in taste receptor cells and nerve fibers innervating taste buds, physiological functions of these substances are not well understood (Nagai et al., 1996).
Weihong Lin, Tatsuya Ogura
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Nicotinic acetylcholine receptors [PDF]
British Journal of Pharmacology, 2018 This themed section of the British Journal of Pharmacology is the product of a conference that focussed on nicotinic ACh receptors (nAChRs) that was held on the Greek island of Crete from 7 to 11 May 2017. ‘Nicotinic acetylcholine receptors 2017’ was the fourth in a series of triennial international meetings that have provided a regular forum for ...
Wonnacott, S +3 more
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Acetylcholine and cholinergic receptors [PDF]
Brain and Neuroscience Advances, 2019 This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic acetylcholine receptors, and some brief comments on possible advances in the near future.
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Nicotinic acetylcholine receptors and epilepsy
Pharmacological Research, 2023 Despite recent advances in understanding the causes of epilepsy, especially the genetic, comprehending the biological mechanisms that lead to the epileptic phenotype remains difficult. A paradigmatic case is constituted by the epilepsies caused by altered neuronal nicotinic acetylcholine receptors (nAChRs), which exert complex physiological functions ...
Becchetti A. +3 more
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Studies on Purified Eel Acetylcholine Receptor and Anti-Acetylcholine Receptor Antibody [PDF]
Proceedings of the National Academy of Sciences, 1973 Rabbit antiserum against purified Electrophorus electricus acetylcholine receptor is studied using an immunoprecipitin assay to measure either antibody titer or concentration of toxin-binding sites in solubilized receptor preparations. This antiserum, unlike control serum, blocks the electrophysiological response of
Jerri Mcmillan +3 more
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Relaxation measurements on the acetylcholine receptor. [PDF]
Proceedings of the National Academy of Sciences, 1975 In Electrophorus electroplaques, the agonist-induced postsynaptic conductance depends on membrane potential. During steady exposure to agonists, after a voltage step the conductance relaxes on a millisecond time scale, exponentially approaching a new equilibrium value.
Sheridan, Robert E., Lester, Henry A.
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Conformation of acetylcholine bound to the nicotinic acetylcholine receptor. [PDF]
Proceedings of the National Academy of Sciences, 1988 We report here the biologically active conformation of acetylcholine when bound to the high-affinity state of the receptor from Torpedo californica. The acetylcholine conformation was determined in the free and bound states by proton NMR two-dimensional nuclear Overhauser effects. In agreement with x-ray crystallographic data, acetylcholine in solution
Tetsuo Yamane +3 more
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Scanning curves and kinetics of the acetylcholine / acetylcholine receptor hysteresis [PDF]
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1988 The high affinity binding of the neurotransmitter acetylcholine (AcCh) to the nicotinic acetylcholine receptor (nAcChR) of the electric organ of Torpedo californica exhibits a pronounced hysteresis and scanning loops. Dialysis conditions lead to an equilibrium binding curve which is coincident with the upper hysteresis branch; K = 5 × 10−9M, 4° C; and ...
Neumann, Eberhard +4 more
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Acetylcholine Receptors and Tau Phosphorylation
Current Molecular Medicine, 2006 Alzheimer's disease (AD) is characterized by the presence, in the brain of the patients, of two aberrant structures: intracellular neurofibrillary tangles (NFTs), containing an abnormal hyperphosphorylated form of tau protein, and extracellular senile plaques (SPs), mainly composed by fibrillar amyloid beta peptide.
Rubio, Alicia +2 more
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Acetylcholine receptors are not functionally independent
Biophysical Journal, 1986 Analysis of current recordings from acetylcholine-activated channels has largely rested so far on the hypothesis of independence, which states that the opening of one channel does not influence that of its neighbors. We have submitted this assumption to several tests, using as experimental material single channel currents from rat myotubes.
Edouard Yeramian +2 more
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