Results 151 to 160 of about 2,529,430 (407)

Larvicidal Activity of Phytochemicals From Handroanthus impetiginosus Seeds Against Culex quinquefasciatus

Chemistry &Biodiversity, EarlyView.
The hexane extract was obtained from the seeds of H. impetiginosus, from which fatty acids and FAMEs were obtained. The three samples were tested on C. quinquefasciatus larvae, promoting mortality with moderate LC50 values. The hexane extract was analyzed by gas chromatographymass spectrometry (GC‐MS), and the most abundant compounds were ethyl oleate (
Luana Cristina Diniz Santos, Lucas Santos Azevedo, Ezequias Pessoa de Siqueira, Mairon César Coimbra, Stênio Nunes Alves, Ana Hortência Fonsêca Castro, Luciana Alves Rodrigues dos Santos Lima   +6 more
wiley   +1 more source

Functional validation of novel levamisole resistance marker S168T in Haemonchus contortus

International Journal for Parasitology: Drugs and Drug Resistance
Recently, a S168T variant in the acetylcholine receptor subunit ACR-8 was associated with levamisole resistance in the parasitic helminth Haemonchus contortus.
Alistair Antonopoulos, Claude L. Charvet, Kirsty Maitland, Stephen R. Doyle, Cédric Neveu, Roz Laing   +5 more
doaj  

Characterization of ibogaine analogs on the hα3β4 nicotinic acetylcholine receptor. [PDF]

, 2012
Nicotine addiction is a global health problem that affects nearly one-third of the population. Animal models have shown that the beta-4 subunit of nicotinic acetylcholine receptors (nAChR) expressed in the habenulointerpeduncular pathway plays a ...
Ross, Jordan
core  

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

A Scalable L‐α‐Glycerophosphorylcholine Synthesis through the Automatic pH‐Controlled (R)‐Glycidol Ring Opening with Phosphorylcholine

Chemistry–Methods, EarlyView.
Automatic titrator enables the regioselective ring opening of (R)‐glycidol in water in the presence of phosphorylcholine, leading to the synthesis of L‐α‐glycerophosphorylcholine, a commercially available drug, in very high yield. The reaction is triggered by a minimum amount of NaOH and reactants, while the optimal pH is precisely regulated through ...
Antonio Massa, Mauro Anibaldi, Lorenzo De Ferra   +2 more
wiley   +1 more source

Bioequivalence of a Donepezil/Memantine 10/20 mg Fixed‐Dose Combination Versus Single‐Component Tablets in Healthy Korean Males

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi, Byung Hak Jin, Do Hoon Keum, Kyoung Hoon Mo, Min Soo Park, Juhwan Lee, Sungjin Park, Choon Ok Kim   +7 more
wiley   +1 more source

The molecular cloning and characterisation of cDNA coding for the alpha subunit of the acetylcholine receptor [PDF]

, 1982
The published version of this article is available at Oxford Journals in Nucleic Acids Research at http://nar.oxfordjournals.org/content/10/19/5809.full.pdf+htmlA rare cDNA coding for most of the α subunit of the Torpedo nicotinic acetylcholine receptor ...
Barnard, EA, Bell, L, Houghton, M, Richards, BM, Smith, JC, Sumikawa, K   +5 more
core   +1 more source

Localization of acetylcholine receptor in excitable membrane from the electric organ of Torpedo: Evidence for exposure of receptor antigenic sites on both sides of the membrane. [PDF]

, 1978
R Tarrab-Hazdai, Benjamin Geiger, Sara Fuchs, Abraham Amsterdam   +3 more
openalex   +1 more source

Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation

Journal of Neuroimmune Pharmacology, 2015
C. Báez-Pagán, Manuel Delgado-Vélez, J. Lasalde-Dominicci   +2 more
semanticscholar   +1 more source

Population Pharmacokinetic and Exposure‐Response Analysis of the Cognitive Effects of TAK‐071 in Participants With Parkinson Disease and Cognitive Impairment

Clinical Pharmacology in Drug Development, EarlyView.
Abstract TAK‐071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK‐071 following single (1‐160 mg) and multiple (3‐15 mg once daily) oral‐dose TAK‐071 in 112 healthy participants ...
Hongxia Jia, Axel Facius, Rachel Jennings, Yaming Hang, Jaya Padmanabhan, Niraj M. Shanbhag, Brian T. Harel, Arthur Simen, Wei Yin   +8 more
wiley   +1 more source