Results 21 to 30 of about 2,529,430 (407)

Acetylcholine and cholinergic receptors [PDF]

Brain and Neuroscience Advances, 2019
This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic acetylcholine receptors, and some brief comments on possible advances in the near future.
openaire   +4 more sources

Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior [PDF]

, 2009
Background To survive and reproduce, animals must be able to modify their motor behavior in response to changes in the environment. We studied a complex behavior of Caenorhabditis elegans, male mating behavior, which provided a model for understanding ...
A Barrios, A Jones, A Jones, AA Beg, Allyson J Whittaker, BA Bamber, BB Wang, BJ Dickinson, C Loer, C Trent, D Weinshenker, DM Raizen, E Culetto, EM Gabriel, G Schindelman, H Ogawa, I Bany, I Putrenko, J Lewis, J Rand, J Richmond, J Srinivasan, J Sulston, J Sze, J White, JQ White, JT Fleming, K Liu, L Carnell, L Garcia, LE Waggoner, M Zhang, MM Francis, O Saifee, P Towers, Paul W Sternberg, RE Ritzmann, S Brenner, S Clark, SH Chalasani, SL McIntire, T Liu, W Schafer, Y Jin, Y Jin, Y Liu   +45 more
core   +4 more sources

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Nature, 2013
Despite recent advances in crystallography and the availability of G-protein-coupled receptor (GPCR) structures, little is known about the mechanism of their activation process, as only the β2 adrenergic receptor (β2AR) and rhodopsin have been ...
A. Kruse, A. Ring, A. Manglik, Jianxin Hu, Kelly Hu, K. Eitel, H. Hübner, E. Pardon, C. Valant, P. Sexton, A. Christopoulos, C. Felder, P. Gmeiner, J. Steyaert, W. Weis, K. Garcia, J. Wess, B. Kobilka   +17 more
semanticscholar   +1 more source

Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants

Critical Care, 2018
Acetylcholine receptor antagonists have been shown to improve outcome in patients with severe acute respiratory distress syndrome. However, it is incompletely understood how these agents improve outcome.
Diana Jansen, Heder de Vries, Leo M. A. Heunks   +2 more
doaj   +1 more source

Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]

, 1995
Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K., Blumenthal, Edward M, Huang, Bo, Vijayaraghavan, Sukumar   +3 more
core   +2 more sources

Anti-inflammation of spirocyclopiperazinium salt compound LXM-10 targeting α7 nAChR and M4 mAChR and inhibiting JAK2/STAT3 pathway in rats. [PDF]

PLoS ONE, 2013
The present study aims to investigate the therapeutic effects of LXM-10 by intragastric administration in both acute and chronic inflammatory models, and to explore the underlying molecular mechanisms.
Weiwei Zhang, Qi Sun, Xiaoli Gao, Yimin Jiang, Runtao Li, Jia Ye   +5 more
doaj   +1 more source

THE NATURE OF ACETYLCHOLINE RECEPTOR [PDF]

Acta Medica Iranica, 1983
The present work with consideratlon to the autoradiographic pictures, suggests that cholinergic receptors are located at the gate of a channel originating from synaptic cleft coming to lie within the muscle fibre. AChE molecules stand at the gate of this
M.E. TASHAYOD
doaj   +1 more source

Review: Dystroglycan in the Nervous System [PDF]

, 2007
Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time.
Matthias Samwald
core   +2 more sources

Correlation of anti-acetylcholine receptor antibody levels and long-term outcomes of juvenile myasthenia gravis in Taiwan: a case control study

BMC Neurology, 2019
Background Myasthenia gravis is the most common disease affecting the neuromuscular junction. The most common etiology among patients with juvenile myasthenia gravis is the production of antibodies against the acetylcholine receptor.
Cheng-Che Chou, I-Chen Su, I-Jun Chou, Jainn-Jim Lin, Shih-Yun Lan, Yi-Shan Wang, Shu-Sing Kong, Yun-Ju Chen, Meng-Ying Hsieh, Po-Cheng Hung, Huei-Shyong Wang, Min-Liang Chou, Kuang-Lin Lin, CHEESE study group   +13 more
doaj   +1 more source

Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously

eLife, 2022
Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from two α-subunits, and one each of the β-, δ-, and ε-subunits.
Christian JG Tessier, Raymond M Sturgeon, Johnathon R Emlaw, Gregory D McCluskey, F Javier Pérez-Areales, Corrie JB daCosta   +5 more
doaj   +1 more source