Results 21 to 30 of about 116,451 (242)
A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor [PDF]
Physical Biology, 3(2):147-159, 2006, 2005 The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin.
arxiv +1 more source
Nicotinic acetylcholine receptors and epilepsy
Pharmacological Research, 2023 Despite recent advances in understanding the causes of epilepsy, especially the genetic, comprehending the biological mechanisms that lead to the epileptic phenotype remains difficult. A paradigmatic case is constituted by the epilepsies caused by altered neuronal nicotinic acetylcholine receptors (nAChRs), which exert complex physiological functions ...
Becchetti A. +3 more
openaire +5 more sources
BMC Neurology, 2019 Background Myasthenia gravis is the most common disease affecting the neuromuscular junction. The most common etiology among patients with juvenile myasthenia gravis is the production of antibodies against the acetylcholine receptor.
Cheng-Che Chou +13 more
doaj +1 more source
Recent Duplication and Functional Divergence in Parasitic Nematode Levamisole-Sensitive Acetylcholine Receptors. [PDF]
PLoS Neglected Tropical Diseases, 2016 Helminth parasites rely on fast-synaptic transmission in their neuromusculature to experience the outside world and respond to it. Acetylcholine plays a pivotal role in this and its receptors are targeted by a wide variety of both natural and synthetic ...
Thomas B Duguet +6 more
doaj +1 more source
Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin [PDF]
Front. Immunol. 2019, 2018 Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes
arxiv +1 more source
Critical Care Research and Practice, 2021 After the introduction of suxamethonium in 1953, cases of cardiac arrest during induction of anesthesia were recorded. In the following years, hyperkalemia was identified as the cause, and the connection to acetylcholine receptor modulation as the ...
Henrik Lynge Hovgaard, Peter Juhl-Olsen
doaj +1 more source
Scientific Reports, 2023 The amygdala is modulated by dopaminergic and cholinergic neurotransmission, and this modulation is altered in mood disorders. Therefore, this study was designed to evaluate the presence/absence of quantitative alterations in the expression of main ...
Daniel Kalinowski +3 more
doaj +1 more source
Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]
World Journal of Research and Review (WJRR) ISSN:2455-3956,
Volume-4, Issue-5, May 2017 Pages 26-30, 2020 Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv
Synaptic transmission as a cooperative phenomenon in confined systems [PDF]
Condens. Matter Phys., 2017, vol. 20, No. 1, 13804, 2017 In this review paper, the theory of synaptic transmission (ST) was developed and discussed. We used the hypothesis of isomorphism between: (a) the cooperative behavior of mediators --- acetylcholine molecules (ACh) and cholinoreceptors in a synaptic cleft with binding into mediator-receptor (AChR) complexes, (b) the critical phenomena in confined ...
arxiv +1 more source
Studies on Purified Eel Acetylcholine Receptor and Anti-Acetylcholine Receptor Antibody [PDF]
Proceedings of the National Academy of Sciences, 1973 Rabbit antiserum against purified Electrophorus electricus acetylcholine receptor is studied using an immunoprecipitin assay to measure either antibody titer or concentration of toxin-binding sites in solubilized receptor preparations. This antiserum, unlike control serum, blocks the electrophysiological response of
Jerri Mcmillan +3 more
openaire +3 more sources