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Acetylcholine receptors and myasthenia
Muscle & Nerve, 2000Much progress has been made in the 26 years since initial studies of the first purified acetylcholine receptors (AChRs) led to the discovery that an antibody-mediated autoimmune response to AChRs causes the muscular weakness and fatigability characteristic of myasthenia gravis (MG) and its animal model, experimental autoimmune myasthenia gravis (EAMG).
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Immunology of the Acetylcholine Receptor
Immunological Communications, 1976Myasthenia gravis is a spontaneously occurring autoimmune disease in which antibodies and lymphocytes are specifically reactive with nicotinic ACh receptors of skeletal muscle. Antibodies reactive with junctional receptors of human muscle are found in 90% of patients with myasthenia gravis and not at all in other diseases.
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Acetylcholinesterase and Acetylcholine Receptor. [PDF]
, 1985 Abstract : Our study of acetylcholinesterase (AcChE) is based on the view that the Beta-trimethylammonio substituent of acetylcholine binds at an uncharged subsite, better termed 'trimethyl' than 'anionic,' and would be more specifically explored by uncharged reagents.
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Acetylcholine Receptor Structure
2003Over the past decade, studies of the atomic structure and the structural mechanism of nicotinic acetylcholine receptor (AChR) gating have reached an advanced stage. AChRs are members and prototypes of the superfamily of Cys-loop pentameric ligand-gated ion channels.
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Is the Acetylcholine Receptor a Rabies Virus Receptor?
Science, 1982Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with α-bungarotoxin and d -tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus ...
Abigail L. Smith +4 more
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Acetylcholine and Its Receptors
1997This chapter explores the role of acetylcholine (ACh) and its receptors in neurogenic control of brain microvascular functions. Experimental results suggest that cerebral blood flow (CBF) increases considerably in the ipsilateral frontal and parietal cortices in response to electrical stimulation of the substantia innominata in rats.
Donald G. Linville, Edith Hamel
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Muscarinic Acetylcholine Receptors
2004Muscarinic acetylcholine receptors are members of the G-protein-coupled receptor superfamily. There are five genes encoding the muscarinic receptors, which are expressed to different extents in a variety of tissues, including cardiac and smooth muscle, secretory glands, and neurons and glial cells in the central and peripheral nervous systems ...
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The acetylcholine receptor: Progress report
Life Sciences, 1974Publisher Summary This chapter presents a progress report on the acetylcholine receptor (ACHR). All approaches to the ACHR begin with the response of cells to ACH and the modification of this response. The binding properties of the ACHR are inferred from the variation of the response as a function of the concentration of ACH and of its congeners.
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Antibodies to the Acetylcholine Receptor
1984The nicotinic acetylcholine receptor (AChR) is one of the key proteins governing the function of the neuromuscular junction. It is the first neurotransmitter receptor to be identified as a molecular entity and to be isolated and purified in an active form.
Miry C. Souroujon +2 more
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2000
Publisher Summary Acetylcholine receptors (AChR) come in two major subtypes, nicotinic and muscarinic, which are named for the agonists that activate them: nicotine and muscarine. Mutations in muscle nAChR subunits produce the congenital fast and slow channel syndromes, while mutations in neuronal nAChRs have been found in nocturnal frontal lobe ...
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Publisher Summary Acetylcholine receptors (AChR) come in two major subtypes, nicotinic and muscarinic, which are named for the agonists that activate them: nicotine and muscarine. Mutations in muscle nAChR subunits produce the congenital fast and slow channel syndromes, while mutations in neuronal nAChRs have been found in nocturnal frontal lobe ...
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