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Human acetylcholine receptors desensitize much faster than rat acetylcholine receptors
Neuroscience Letters, 1989The process of acetylcholine receptor (AChR) desensitization in the presence of transmitter was evaluated for human myoballs and medullo-blastoma cells. The cell under investigation was placed in one of two parallel streams of solution ejected from a double-barrelled pipette.
Siara, J., Ruppersberg, J., Rüdel, R.
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Nicotinic Acetylcholine Receptor Assays
Current Protocols in Pharmacology, 1999AbstractNicotinic acetylcholine receptors (nAChRs) in peripheral tissues are localized almost exclusively to autonomic nerves and the motor end plates of striated musculature. Pharmacologic analyses of nicotinic receptor antagonist potencies can be conducted by assessing the ability of these compounds to inhibit responses elicited by preganglionic ...
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Trends in Pharmacological Sciences, 1979
Neurons communicate with their target cells mostly by chemical means. The molecules involved, neurotransmitters. are in general small molecules which are liberated by nerve terminals upon rapid variation of the membrane potential. The ch.ange of neurotransmitter concentration in the synapse with time constitutes the ‘signal’ for inter-cellular ...
Jérôme Giraudat, Jean-Pierre Changeux
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Neurons communicate with their target cells mostly by chemical means. The molecules involved, neurotransmitters. are in general small molecules which are liberated by nerve terminals upon rapid variation of the membrane potential. The ch.ange of neurotransmitter concentration in the synapse with time constitutes the ‘signal’ for inter-cellular ...
Jérôme Giraudat, Jean-Pierre Changeux
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Acetylcholine receptors and myasthenia
Muscle & Nerve, 2000Much progress has been made in the 26 years since initial studies of the first purified acetylcholine receptors (AChRs) led to the discovery that an antibody-mediated autoimmune response to AChRs causes the muscular weakness and fatigability characteristic of myasthenia gravis (MG) and its animal model, experimental autoimmune myasthenia gravis (EAMG).
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The acetylcholine receptor: Progress report
Life Sciences, 1974Publisher Summary This chapter presents a progress report on the acetylcholine receptor (ACHR). All approaches to the ACHR begin with the response of cells to ACH and the modification of this response. The binding properties of the ACHR are inferred from the variation of the response as a function of the concentration of ACH and of its congeners.
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Neuronal Nicotinic Acetylcholine Receptors
1996Studies of the structure and function of neuronal nicotinic acetylcholine receptors (AChRs) evolved out of studies of muscle AChRs. This review will begin with a brief summary of muscle type AChRs because they are the archetype for studies of neuronal nicotinic AChRs in particular and ligand-gated ion channels in general.
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Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
Journal of Molecular Biology, 2005N. Unwin
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Structure and gating mechanism of the acetylcholine receptor pore
Nature, 2003A. Miyazawa, Y. Fujiyoshi, N. Unwin
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