Results 321 to 330 of about 2,919,475 (397)

Optimizing PCR amplification of GC-rich nicotinic acetylcholine receptor subunits from invertebrates. [PDF]

Biochem Biophys Rep
Tanveer Khan M, Belgrano C, Rufener L, Horsberg TE, Bakke MJ.   +4 more
europepmc   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, EarlyView.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Activation of the α7 nicotinic acetylcholine receptor mitigates cognitive deficits in mice with sepsis-associated encephalopathy by inhibiting microglial pyroptosis. [PDF]

World J Emerg Med
Wang Q, Luo Q, Su Z, Xu Y, Peng L, Wen Y, Zeng H, Ding H.   +7 more
europepmc   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, EarlyView.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Discovery of Zilucoplan: A Complement C5 Inhibitor for Treatment of Anti-Acetylcholine Receptor (AChR) Antibody-Positive Generalized Myasthenia Gravis (gMG). [PDF]

J Med Chem
Ye P, Hammer RP, Wang Z, Dhamnaskar K, Hoarty M, Ma Z, Tang GQ, DeMarco SJ, Ricardo A.   +8 more
europepmc   +1 more source

Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor. [PDF]

Mol Pharmacol
Chen K, Park E, Abd-Elrahman KS.
europepmc   +1 more source

Unilateral Ptosis and Bulbar Symptoms as the Initial Presentation of Late-Onset Acetylcholine Receptor Antibody-Positive Myasthenia Gravis Mimicking Acute Ischemic Stroke in an 82-Year-Old Man. [PDF]

Cureus
Mangrio SM, Faisal S, Malik Z, Naeem A, Saeed U.   +4 more
europepmc   +1 more source

Refinement of the rat acetylcholine receptor-specific passive transfer myasthenia gravis model using subcutaneous injections: an update to the guidelines. [PDF]

Sci Rep
Arets B, Mané-Damas M, Schöttler AK, Sikorski PM, Kusner LL, Kaminski HJ, Losen M, Martinez-Martinez P.   +7 more
europepmc   +1 more source

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy. [PDF]

ACS Chem Neurosci
Gregro AR, Park C, Long MF, Baker LA, Bollinger KA, Ringuette AE, Peng L, Luscombe VB, Billard NB, Rodriguez AL, Niswender CM, Peng W, Dickerson JW, Rook JM, O'Neill J, Chang S, Boonen HCM, Jensen T, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +24 more
europepmc   +1 more source

Comparison of anti-desmoglein antibodies titres and anti-M3 muscarinic acetylcholine receptor antibody titres as biomarker for potential pemphigus between subjects who are occupationally exposed and not exposed to pesticides

Dipankar De, Divya Kamat, Maninder Kaur, Dev Kumari, Arnab Pal, Sanjeev Handa, Siby John, Ravindra Khaiwal   +7 more
openalex   +1 more source