Results 61 to 70 of about 116,451 (242)
Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation [PDF]
arXiv, 2018 Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered ("raft" or $l_o$) domains or cholesterol-poor liquid ...
arxiv
Frontiers in Neural Circuits, 2014 In drug users, drug-related cues alone can induce dopamine release in the dorsal striatum. Instructive cues activate inputs to the striatum from both dopaminergic and cholinergic neurons, which are thought to work together to support motor learning and ...
Jill R Crittenden +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2010 We investigated pharmacological characteristics of the itch-associated response to chronic dermatitis induced by 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) repeated application in mice.
Yukihito Tsukumo +2 more
doaj
Opening a hydrophobic gate: the nicotinic acetylcholine receptor as an example [PDF]
arXiv, 2009 To what extent must a hydrophobic gate expand for the channel to count as open? We address this question using the nicotinic acetylcholine receptor (nAChR) as the exemplar. The nAChR is an integral membrane protein which forms a cation selective channel gated by neurotransmitter binding to its extracellular domain.
arxiv
Toxics, 2018 Among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic ...
Anna Maria Lavezzi
doaj +1 more source
PET mapping of receptor occupancy using joint direct parametric reconstruction [PDF]
Receptor occupancy (RO) studies using PET neuroimaging play a critical role in the development of drugs targeting the central nervous system (CNS). The conventional approach to estimate drug receptor occupancy consists in estimation of binding potential changes between two PET scans (baseline and post-drug injection).
arxiv +1 more source
Journal of Biological Chemistry, 1982 Functionally intact acetylcholine receptors can be solubilized from electric organ membranes of Torpedo californica and incorporated into liposomes by the cholate dialysis technique. Freezing and thawing of the reconstituted preparation appears to seal a population of initially leaky vesicles and leads to vesicle fusion.
Mark H. Ellisman +5 more
openaire +3 more sources
Muscarinic receptor signaling in the pathophysiology of asthma and COPD
Respiratory Research, 2006 Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for asthma. Primarily used as bronchodilators, they reverse the action of vagally derived acetylcholine on airway smooth muscle contraction.
Zaagsma Johan +3 more
doaj +1 more source
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics [PDF]
Journal of Computational Neuroscience 24, 253-276 (2008), 2007 To establish the relationship between locomotory behavior and dynamics of neural circuits in the nematode C. elegans we combined molecular and theoretical approaches. In particular, we quantitatively analyzed the motion of C. elegans with defective synaptic GABA and acetylcholine transmission, defective muscle calcium signaling, and defective muscles ...
arxiv
The surface accessibility of α-bungarotoxin monitored by a novel paramagnetic probe [PDF]
arXiv, 2011 The surface accessibility of {\alpha}-bungarotoxin has been investigated by using Gd2L7, a newly designed paramagnetic NMR probe. Signal attenuations induced by Gd2L7 on {\alpha}-bungarotoxin C{\alpha}H peaks of 1H-13C HSQC spectra have been analyzed and compared with the ones previously obtained in the presence of GdDTPA-BMA. In spite of the different
arxiv