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Acetylcholinesterase

Angewandte Chemie International Edition in English, 1967
AbstractAcetylcholinesterase plays a vital part in the functioning of nerves, and serious physiological damage arises from its blockage by esters of phosphonic and phosphoric acid used e. g. in pesticides. The properties and the mechanism of action of acetylcholinesterase, which show many similarities to those of other hydrolases, are described ...
N, Engelhard, K, Prchal, M, Nenner
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Acetylcholinesterase kinetics

Biophysics of Structure and Mechanism, 1980
Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
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Breathing Without Acetylcholinesterase

2004
Acetylcholine (ACh) mediates neurotransmission at the neuromuscular junction and is involved in respiratory control1, notably chemosensitivity2 of central and peripheral origin. The level of ACh at the synaptic cleft and neuromuscular junction is regulated by the enzyme acetylcholinesterase (AChE).
Chatonnet, Fabrice   +4 more
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