Results 251 to 260 of about 85,087 (299)

Molecular Dynamics of Acetylcholinesterase

Accounts of Chemical Research, 2002
Molecular dynamics simulations are leading to a deeper understanding of the activity of the enzyme acetylcholinesterase. Simulations have shown how breathing motions in the enzyme facilitate the displacement of substrate from the surface of the enzyme to the buried active site.
Shen, Tongye, Tai, Kaihsu, Henchman, Richard H., McCammon, J. Andrew   +3 more
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ACETYLCHOLINESTERASE

Canadian Journal of Biochemistry, 1964
The general characteristics of acetylcholinesterase are described. The mechanism of action of the enzyme is considered primarily in relation to the two steps in the hydrolysis of acetylcholine, the acetylation and deacetylation reactions. Competitive and non-competitive inhibition, and inhibitions by hydrogen ion and by substrate, are explained in ...
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Toward an Artificial Acetylcholinesterase

Chemistry - A European Journal, 2000
The methanolysis of choline p-nitrophenylcarbonate in chloroform containing 1% methanol is catalyzed with turnover by ditopic receptors 1 and 2, consisting of a calix[6]arene connected to a bicyclic guanidinium by means of a short spacer. The calix[6]arene subunit strongly binds to the trimethylammonium head group through cation-pi interactions ...
CUEVAS F., DI STEFANO, Stefano, MAGRANS J. O., PRADOS P., MANDOLINI, Luigi, DE MENDOZA J.   +5 more
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Breathing Without Acetylcholinesterase

2004
Acetylcholine (ACh) mediates neurotransmission at the neuromuscular junction and is involved in respiratory control1, notably chemosensitivity2 of central and peripheral origin. The level of ACh at the synaptic cleft and neuromuscular junction is regulated by the enzyme acetylcholinesterase (AChE).
Chatonnet, Fabrice, Boudinot, Eliane, Chatonnet, Arnaud, Champagnat, Jean, Foutz, Arthur   +4 more
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Autoantibodies to acetylcholinesterase revisited

Journal of the Neurological Sciences, 2000
A sensitive and specific enzyme linked immunosorbent assay (ELISA) utilizing human recombinant acetylcholinesterase has been employed for the detection of human antibodies to human acetylcholinesterase. The method can detect allogenic antibodies to the Yt(a) form of human erythrocyte AChE. Adaptation of this ELISA method allowed the IgG subclass typing
J, Geen, S, Hadjikoutis, A, Strachan, D A, Hullin, S I, Hogg, C M, Wiles   +5 more
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Acetylcholinesterase inhibitors in MG: To be or not to be?

Muscle & Nerve, 2009
AbstractMyasthenia gravis (MG) is an autoimmune disorder usually caused by antibodies against either the acetylcholine receptor (AChR) or muscle‐specific tyrosine kinase (MuSK) at the neuromuscular junction. Neuromuscular transmission failure results in muscle fatigue and weakness that can be treated symptomatically with acetylcholinesterase inhibitors
Anna Rostedt, Punga, Erik, Stålberg
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Acetylcholinesterase in the human retina

Brain Research, 1987
The distribution of cholinesterase activity in the human retina was evaluated using histochemical methods. The butyrylcholine esterase (BuChE) inhibitor tetraisopropylpyrophosphoramide was used to localize acetylcholinesterase (AChE) activity, the AChE inhibitor BW284c51 was used to localize BuChE activity, and eserine was used to inhibit all ...
J B, Hutchins, J G, Hollyfield
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Stereospecificity of erythrocyte acetylcholinesterase

Archives of Biochemistry and Biophysics, 1964
Abstract Lactoylcholine is a choline ester which contains an asymmetric carbon atom in the acid portion of the molecule. A study of the hydrolytic rate of the enantiomers of this choline ester by human erythrocyte acetylcholinesterase revealed that the l (+) isomer is hydrolyzed at least four times greater than the d (−) isomer.
J V, AUDITORE, B V, SASTRY
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Acetylcholinesterase

1987
International ...
Toutant, J.P., Massoulie, J.
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Activation of acetylcholinesterase by vanadate

Neuropharmacology, 1985
Vanadate activated acetylcholinesterase in rat ventricular strips. This effect of probably due to the action of vanadate (V) form rather than to vanadyl (IV). Vanadate also activated purified acetylcholinesterase from the electric eel and also erythrocytes, suggesting a direct effect upon this enzyme system.
R E, Catalán, A M, Martínez, M D, Aragonés, J E, Godoy   +3 more
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