In-vitro modelling of Alzheimer's disease using cholinergic neurons derived from human neuroblastoma (SH-SY5Y) retinoic acid-induced differentiation. [PDF]
Zainuddin MS +4 more
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Prescription cascades associated with acetylcholinesterase inhibitors use: a high-throughput sequence symmetry analysis. [PDF]
Newby D +14 more
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Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi-Target Inhibitors of Cholinesterases and Carbonic Anhydrases. [PDF]
Ünlü S +3 more
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A tale of three mimickers: Amitraz, fipronil, and 2,4-dichlorophenoxyacetic acid poisoning confounding organophosphate toxicity. [PDF]
Bhimani KS +4 more
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Correction to "An Expedient Synthesis of 2-Acylthiazoles and 2-Acyl-4-methyl-5-acetylthiazoles Using α-Ketothioamides as Potential Acetylcholinesterase Inhibitors". [PDF]
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AbstractAcetylcholinesterase plays a vital part in the functioning of nerves, and serious physiological damage arises from its blockage by esters of phosphonic and phosphoric acid used e. g. in pesticides. The properties and the mechanism of action of acetylcholinesterase, which show many similarities to those of other hydrolases, are described ...
N, Engelhard, K, Prchal, M, Nenner
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Tetrahydrocannabinol and acetylcholinesterase
Pharmacology Biochemistry and Behavior, 1978Recent evidence suggests that the psychoactive effect of delta-9-tetrahydrocannabinol (delta9-THC), the major psychoactive constituent of marihuana, may be mediated through an alteration of cholinergic neurotransmission. One possible mechanism by which delta9-THC could have its effect is by affecting acetylcholinesterase (AChE) and there is evidence ...
D E, Moss, P L, Peck, R, Salome
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Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
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