Results 171 to 180 of about 218,218 (394)

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

An acetyltransferase effector conserved across Legionella species targets the eukaryotic eIF3 complex to modulate protein translation

mBio
The survival of Legionella spp. as intracellular pathogens relies on the combined action of protein effectors delivered inside their eukaryotic hosts by the Dot/Icm (defective in organelle trafficking/intracellular multiplication) type IVb secretion ...
Lukas Syriste, Deepak T. Patel, Peter J. Stogios, Tatiana Skarina, Dhruvin Patel, Alexei Savchenko   +5 more
doaj   +1 more source

NAT10 regulates tumor progression and immune microenvironment in pancreatic ductal adenocarcinoma via the N4‐acetylated LAMB3‐mediated FAK/ERK pathway

Cancer Communications, EarlyView.
Abstract Background N‐acetyltransferase 10 (NAT10) was reported to be associated with the immune microenvironment in several cancers. However, it is not known in pancreatic ductal adenocarcinoma (PDAC). This study aimed to elucidate the roles and mechanisms of NAT10 in tumor malignancy and the tumor microenvironment (TME) in PDAC.
Enhong Chen, Qin Wang, Leisheng Wang, Zebo Huang, Dongjie Yang, Changyong Zhao, Wuqiang Chen, Shuo Zhang, Shuming Xiong, Youzhao He, Yong Mao, Hao Hu   +11 more
wiley   +1 more source

Reduction of Fusarium head blight and trichothecene contamination in transgenic wheat expressing Fusarium graminearum trichothecene 3-O-acetyltransferase

Frontiers in Plant Science
Fusarium graminearum, the causal agent of Fusarium head blight (FHB), produces various mycotoxins that contaminate wheat grains and cause profound health problems in humans and animals.
Gabdiel Yulfo-Soto, Gabdiel Yulfo-Soto, Susan McCormick, Hui Chen, Guihua Bai, Guihua Bai, Harold N. Trick, Guixia Hao   +7 more
doaj   +1 more source

Regional distribution of choline acetyltransferase in the human brain: changes in Huntington's chorea. [PDF]

, 1975
Sten‐Magnus Aquilonius, S.‐Å. Eckernäs, A. Sundwall   +2 more
openalex   +1 more source

Antibacterial Essential Oils as Adjuvants to Inhibit Antibiotic Resistance in Multidrug‐resistant Bacteria

Chemistry &Biodiversity, EarlyView.
Combining bacterially inactivated antibiotics with antibacterial essential oils (EOs) is an alternative combinatorial therapy against antibiotic‐resistant bacteria, as EOs can also modulate resistance. Apart from the rehabilitation of the antibiotic, this combination is probably more difficult to overcome evolutionarily due to the antibacterial mixture
Rafael Torres‐Martínez, Yolanda Magdalena García‐Rodríguez, María Guadalupe Ramírez‐Ortiz, Tzasná Hernández‐Delgado, Guillermo Delgado, Francisco Javier Espinosa‐García   +5 more
wiley   +1 more source

Exploring the Effect of Resveratrol, Tyrosol, and Their Derivatives on Platelet-Activating Factor Biosynthesis in U937 Cells

Molecules
Platelet-activating factor (PAF) is a potent lipid mediator, involved in thrombosis, inflammation, and atherosclerosis. The protective effect of wine and olive oil against atherosclerotic diseases is largely attributed to their phenolic compounds and ...
Filio Petsini, Maria Detopoulou, Maria Choleva, Ioannis K. Kostakis, Elizabeth Fragopoulou, Smaragdi Antonopoulou   +5 more
doaj   +1 more source

Multiple forms of choline acetyltransferase in several species demonstrated by isoelectric focusing [PDF]

, 1972
D. Malthe‐Sørenssen, Frode Fonnum
openalex   +1 more source

5‐thiohistidine N‐acetyltransferase from Proteiniphilum saccharofermentans

ChemBioChem, Accepted Article.
Ovothiol A is a 5‐thiohistidine derivative biosynthesized by a broad range of prokaryotic and eukaryotic organisms. Its redox‐active mercaptoimidazole side chain is believed to protect cells from oxidative stress. The three enzymes that produce ovothiol A from histidine, cysteine, and S‐adenosyl methionine have been identified and characterized.
Cangsong Liao, David Lim, Gladwin Suryatin Alim, Florian P. Seebeck   +3 more
wiley   +1 more source

Identification of a New Family of Enzymes with Potential \u3cem\u3eO\u3c/em\u3e-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria [PDF]

, 2005
Background: The metabolism of the rigid bacterial cell wall heteropolymer peptidoglycan is a dynamic process requiring continuous biosynthesis and maintenance involving the coordination of both lytic and synthetic enzymes.
Clarke, Anthony J., Pfeffer, John M., Weadge, Joel T.   +2 more
core   +1 more source