Enzymatic Modification of Aminoglycoside Antibiotics: 3- N -Acetyltransferase with Broad Specificity that Determines Resistance to the Novel Aminoglycoside Apramycin [PDF]
, 1978 Julian Davies, Sean O'Connor
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A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations
ChemBioChem, EarlyView.Site‐specifically phosphorylated isoforms of the tumor suppressor p53 – encompassing all seven known phosphorylation sites within the TAD1 domain –are created upon optimization of semisynthesis protocols. This “designer" p53 library enabled validation of phosphorylation‐specific p53 antibodies and revealed epitope masking by phosphorylation in commonly
Mateusz Hess +6 more
wiley +1 more source
Human Placental Choline Acetyltransferase [PDF]
, 1971 David Morris, Darshan S. Grewaal
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In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins
ChemBioChem, Accepted Article.Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska +2 more
wiley +1 more source
ChemBioChem, Accepted Article.Hydrazine synthetases (HSs), consisting of cupin and methionyl‐tRNA synthetase (MetRS)‐like domains, catalyze hydrazine formation in the biosynthesis of various nitrogen‐nitrogen (N‐N) bond‐containing secondary metabolites. The structural diversity of the N‐N bond‐containing secondary metabolites synthesized using this system is attributed to the ...
Yusuke Shikai +4 more
wiley +1 more source
Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes
Cell Biology International, EarlyView.ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio +6 more
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Properties of Partially Purified Carnitine Acetyltransferase
, 1963 Irving B. Fritz +2 more
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Partial Purification and Properties of
, 1974 Thomas H. Giddings, Edward C. Cantino
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Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis
ChemistryEurope, EarlyView.This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
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The Distribution of Carnitine, Acetylcarnitine, and Carnitine Acetyltransferase in Rat Tissues
, 1965 Norman R. Marquis, Irving B. Fritz
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