Results 11 to 20 of about 203,618 (332)

Spotlight on Plant Bromodomain Proteins

Biology, 2023
Bromodomain-containing proteins (BRD-proteins) are the “readers” of histone lysine acetylation, translating chromatin state into gene expression.
Eirini Bardani, Paraskevi Kallemi, Martha Tselika, Konstantina Katsarou, Kriton Kalantidis   +4 more
doaj   +1 more source

Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification

Biomolecules, 2023
p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution of malignant ...
Qingmei Zeng, Kun Wang, Yongxiang Zhao, Qingzhi Ma, Zhinan Chen, Wan Huang   +5 more
doaj   +1 more source

Identification of acetylated diether lipids in halophilic Archaea

MicrobiologyOpen, 2022
As a hallmark of Archaea, their cell membranes are comprised of ether lipids. However, Archaea‐type ether lipids have recently been identified in Bacteria as well, with a somewhat different composition: In Bacillales, sn‐glycerol 1‐phosphate is ...
Cosimo Kropp, Julius Lipp, Anna Lena Schmidt, Christina Seisenberger, Mona Linde, Kai‐Uwe Hinrichs, Patrick Babinger   +6 more
doaj   +1 more source

Mechanisms of NAT10 as ac4C writer in diseases

Molecular Therapy: Nucleic Acids, 2023
In the early stage, N4-acetylcytidine (ac4C) was regarded as a conservative nucleoside present on tRNA and rRNA. Recently, studies have shown that ac4C also exists in human and yeast mRNA.
Lihua Xie, Xiaolin Zhong, Wenyu Cao, Jianghua Liu, Xuyu Zu, Ling Chen   +5 more
doaj   +1 more source

Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80

Frontiers in Chemistry, 2023
Acetylation of protein N-termini is one of the most common protein modifications in the eukaryotic cell and is catalyzed by the N-terminal acetyltransferase family of enzymes.
Line M. Myklebust, Markus Baumann, Markus Baumann, Svein I. Støve, Håvard Foyn, Thomas Arnesen, Thomas Arnesen, Thomas Arnesen, Bengt Erik Haug   +8 more
doaj   +1 more source

Gcn5-Related N-Acetyltransferases (GNATs) With a Catalytic Serine Residue Can Play Ping-Pong Too

Frontiers in Molecular Biosciences, 2021
Enzymes in the Gcn5-related N-acetyltransferase (GNAT) superfamily are widespread and critically involved in multiple cellular processes ranging from antibiotic resistance to histone modification.
Jackson T. Baumgartner, Thahani S. Habeeb Mohammad, Mateusz P. Czub, Mateusz P. Czub, Karolina A. Majorek, Karolina A. Majorek, Xhulio Arolli, Cillian Variot, Madison Anonick, Wladek Minor, Wladek Minor, Miguel A. Ballicora, Daniel P. Becker, Misty L. Kuhn   +13 more
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Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the teleost cyprinus carpio [PDF]

, 2018
Cholinergic systems play a role in basic cerebral functions and its dysfunction is associated with deficit in neurodegenerative disease. Mechanisms involved in human brain diseases, are often approached by using fish models, especially cyprinids, given ...
Casini, Arianna, Cioni, Carla, Toni, Mattia, Vaccaro, Rosa   +3 more
core   +2 more sources

INFLUENCE OF DELETION POLYMORPHISM OF GSTM1 AND NAT2 GENES ON THE PREDICTION OF DRUG-SENSITIVE TUBERCULOSIS TREATMENT EFFICACY

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019
The aim of the study. To determine the ffect of polymorphism of glutathione-S-transferase class M1 and NAT2 genes on the efficacy of tuberculosis treatment. Material and methods.
Todoriko L. D., Semianiv I. A., Kuzhko М. М.   +2 more
doaj   +1 more source

The Processing, Gene Regulation, Biological Functions, and Clinical Relevance of N4-Acetylcytidine on RNA: A Systematic Review

Molecular Therapy: Nucleic Acids, 2020
N4-acetylcytidine (ac4C) is often considered to be a conservative, chemically modified nucleoside present on tRNA and rRNA. Recent studies have shown extensive ac4C modifications in human and yeast mRNAs.
Gehui Jin, Mingqing Xu, Mengsha Zou, Shiwei Duan   +3 more
doaj   +1 more source

Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice

Biomolecules, 2021
B lymphocyte development has two DNA recombination processes: V(D)J recombination of the immunoglobulin (Igh) gene variable region, and class switching of the Igh constant regions from IgM to IgG, IgA, or IgE.
Valentyn Oksenych, Dan Su, Jeremy A. Daniel   +2 more
doaj   +1 more source