Results 281 to 290 of about 218,218 (394)

Electrocochleographic Changes Predict an Early Sign of Cochlear Degeneration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The purpose of this study is to identify the earliest appearing auditory electrophysiological indicators that change with age progression in young adults with normal hearing, and to analyze the frequency distribution patterns of these markers in the cochlear.
Min‐Fei Qian, Hao Chen, Qi‐Xuan Wang, Ya‐Qi Zhou, Xiao‐Lu Chen, Zhi‐Wu Huang, Ji‐Ping Li   +6 more
wiley   +1 more source

The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of <i>Candida auris</i>. [PDF]

mSphere
Chauhan M, Shivarathri R, Aptekmann AA, Chowdhary A, Kuchler K, Desai JV, Chauhan N.   +6 more
europepmc   +1 more source

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

Decoding a novel non-enzymatic protein acetylation mechanism in sperm that is essential for fertilizing potential. [PDF]

Biol Res
Iniesta-Cuerda M, Nevoral J, Krapf D, Garde J, Soler-Valls AJ, Yeste M.   +5 more
europepmc   +1 more source

Purification and characterization of an N alpha-acetyltransferase from Saccharomyces cerevisiae.

, 1988
Fang‐Jen S. Lee, L W Lin, John A. Smith   +2 more
openalex   +1 more source

Type‐Specific Single‐Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes

Aging Cell, EarlyView.
(a) Mitochondria contain wild‐type (black)/mutant (red) mtDNA; exceeding the mtDNA mutation threshold compromises OXPHOS, potentially driving degeneration of neurons vulnerable to age‐related neurodegenerative disease. Cellular compensations that is, mtDNA copy number upregulation and crosstalk with nuclear DNA may fail, driving neurodegeneration ...
Eloise J. Stephenson, Laura J. Bailey, Stephen Gentleman, Helen Tuppen, Istvan Bodi, Claire Troakes, Christopher M. Morris, Tony M. Carr, Sarah Guthrie, Joanna L. Elson, Ilse S. Pienaar   +10 more
wiley   +1 more source

Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?

Aging Cell, EarlyView.
Cockayne Syndrome complementation group B (CS‐B) is a highly debilitating progeroid syndrome that often culminates in the death of patients before adulthood. This review explores the pathogenesis of CS‐B and proposes that a combination of DNA damage accumulation, transcriptional dysregulation, and mitochondrial dysfunction is its underlying cause ...
Ricardo Afonso‐Reis, Cristiana R. Madeira, David V. C. Brito, Clévio Nóbrega   +3 more
wiley   +1 more source

The multilayered control of acetylation during adenovirus-based immunotherapy of cancer. [PDF]

Mol Ther Oncol
Parthasarathy A, Frost M, Gillard AG, Alonso MM, Gomez-Manzano C, Fueyo J.   +5 more
europepmc   +1 more source

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity

Aging Cell, EarlyView.
In this work, we found that birds with similar lifespans exhibit convergent evolution in specific genes, suggesting that shared evolutionary pressures shape the genetic basis of lifespan similarity across species. By investigating protein–protein interactions across genes evolving convergently in long‐ and short‐lived species, we identified a network ...
Mirko Martini, Giovanni Piccinini, Liliana Milani, Mariangela Iannello   +3 more
wiley   +1 more source

Molecular weight determinations of soluble and membrane-bound fractions of choline O-acetyltransferase in rat brain

, 1985
M. Badamchian, PT Carroll
openalex   +1 more source