Results 221 to 230 of about 38,885 (308)

Interferon-β and interleukin-6 exert opposing effects on Foxp3 acetylation to control regulatory T cell induction. [PDF]

open access: yesFront Immunol
Ningoo M   +5 more
europepmc   +1 more source

A Smart Functional Microneedle, Tethered with Neuropeptide S and Tissue Inhibitor of Metalloproteinases, Promotes Skin, Vascular, and Nerve Regeneration for Chronic Diabetic Skin Wound Healing

open access: yesSmall Structures, EarlyView.
A smart functional microneedle system, tethered with NPS and TIMP, which not only promotes diabetic wound healing and tissue remodeling at the injury site but also demonstrates the ability to dynamically and responsively release NPS and TIMP as needed, offering a potential therapeutic approach for clinical translation is presented. Increased expression
Yan Gao   +5 more
wiley   +1 more source

Electrocochleographic Changes Predict an Early Sign of Cochlear Degeneration

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The purpose of this study is to identify the earliest appearing auditory electrophysiological indicators that change with age progression in young adults with normal hearing, and to analyze the frequency distribution patterns of these markers in the cochlear.
Min‐Fei Qian   +6 more
wiley   +1 more source

Type‐Specific Single‐Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes

open access: yesAging Cell, EarlyView.
(a) Mitochondria contain wild‐type (black)/mutant (red) mtDNA; exceeding the mtDNA mutation threshold compromises OXPHOS, potentially driving degeneration of neurons vulnerable to age‐related neurodegenerative disease. Cellular compensations that is, mtDNA copy number upregulation and crosstalk with nuclear DNA may fail, driving neurodegeneration ...
Eloise J. Stephenson   +10 more
wiley   +1 more source

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity

open access: yesAging Cell, EarlyView.
In this work, we found that birds with similar lifespans exhibit convergent evolution in specific genes, suggesting that shared evolutionary pressures shape the genetic basis of lifespan similarity across species. By investigating protein–protein interactions across genes evolving convergently in long‐ and short‐lived species, we identified a network ...
Mirko Martini   +3 more
wiley   +1 more source

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