Results 31 to 40 of about 95,792 (372)

MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins

Nature Communications, 2023
Altered transcriptional machinery promotes aberrant self-renewal of non-stem hematopoietic progenitors. Here the authors show that AF10 fusion proteins cause aberrant self-renewal via ENL, which promotes leukemic transformation by binding to MOZ/MORF ...
Yosuke Komata, Akinori Kanai, Takahiro Maeda, Toshiya Inaba, Akihiko Yokoyama   +4 more
doaj   +1 more source

PanM, an Acetyl-Coenzyme A Sensor Required for Maturation of l-Aspartate Decarboxylase (PanD)

mBio, 2012
Coenzyme A (CoA) is essential for cellular chemistry in all forms of life. The pantothenate moiety of CoA is generated from the condensation of pantoate and β-alanine.
Tara N. Stuecker, Alex C. Tucker, Jorge C. Escalante-Semerena   +2 more
doaj   +1 more source

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. [PDF]

, 2019
Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules.
Andersen, Julie, Butler, Victoria J, Chamoli, Manish, Jung, Manfred, Kao, Aimee W, Ng, Che-Ping, Simon, Roman P, Tezil, Tugsan, Verdin, Eric   +8 more
core   +1 more source

Positional proteomics reveals differences in N-terminal proteoform stability [PDF]

, 2016
To understand the impact of alternative translation initiation on a proteome, we performed a proteome-wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes.
Brown JL, Daria Gawron, Elvis Ndah, Kris Gevaert, Petra Van Damme   +4 more
core   +2 more sources

A role for human N-alpha acetyltransferase 30 (Naa30) in maintaining mitochondrial integrity [PDF]

, 2016
N-terminal acetylation (Nt-acetylation) by N-terminal acetyltransferases (NATs) is one of the most common protein modifications in eukaryotes. The NatC complex represents one of three major NATs of which the substrate profile remains largely unexplored ...
Arnesen, Thomas, Gevaert, Kris, Jonckheere, Veronique, Kalvik, Thomas V, Menschaert, Gerben, Myklebust, Line M, Starheim, Kristian W, Van Damme, Petra, Varhaug, Jan Erik   +8 more
core   +2 more sources

Systems Biology and Pangenome of Salmonella O-Antigens. [PDF]

, 2019
O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to
Kavvas, Erol, Machado, Henrique, Monk, Jonathan M, Palsson, Bernhard O, Seif, Yara   +4 more
core   +2 more sources

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection. [PDF]

, 2017
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Alland, Aung, Azad, Bannister, Barchowsky, Bell, Bird, Brilha, Chen, Chernov, Choudhary, Culley, de Ruijter, Dobaczewski, Elkington, Feng, Goldberg, Green, Gregoire, Gregoretti, Horiuchi, Jaspers, Khan, Kim, Kleinsteuber, Kubler, Kumar, Lee, Loffek, Lu, Maciejewska-Rodrigues, Majeed, McErlean, McGarry Houghton, Michael, Mittelstadt, Mortaz, Moser, Nasu, Omanakuttan, Ong, Ong, Roger, Shahbazian, Shammari, Singh, Swamy, Tezera, Thuong, Wallis, Wang, Wang, Wolffe   +52 more
core   +2 more sources

Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Becker, Peter, Eberharter, Anton, Ferreira, Roger   +2 more
core   +1 more source

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

Bioessays, 2018
Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair.
A. Voss, T. Thomas
semanticscholar   +1 more source

Phenotypic Differentiation Within the aac(6′) Aminoglycoside Resistance Gene Family Suggests a Novel Subtype IV of Contemporary Clinical Relevance

Antibiotics
Background: Whole genome sequencing of clinical bacterial isolates holds promise in predicting their susceptibility to antibiotic therapy, based on a detailed understanding of the phenotypic manifestation of genotypic variation.
Michel Plattner, Maurizio Catelani, Sarah-Lisa Gmür, Maximilian Hartmann, Fatmanur Kiliç, Klara Haldimann, David Crich, Sven N. Hobbie   +7 more
doaj   +1 more source