Results 41 to 50 of about 91,412 (386)

Regulation of skeletal muscle development and homeostasis by gene imprinting, histone acetylation and microRNA [PDF]

, 2015
Epigenetics is defined as heritable information other that the DNA sequence itself. The concept implies that the regulation of gene expression is highly complex and epigenetics can control from fine tuning to permanent gene activation/deactivation ...
ADAMO, Sergio, COLETTI, Dario, MARRONCELLI, NICOLETTA, MORESI, Viviana   +3 more
core   +2 more sources

Phenotypic Differentiation Within the aac(6′) Aminoglycoside Resistance Gene Family Suggests a Novel Subtype IV of Contemporary Clinical Relevance

Antibiotics
Background: Whole genome sequencing of clinical bacterial isolates holds promise in predicting their susceptibility to antibiotic therapy, based on a detailed understanding of the phenotypic manifestation of genotypic variation.
Michel Plattner, Maurizio Catelani, Sarah-Lisa Gmür, Maximilian Hartmann, Fatmanur Kiliç, Klara Haldimann, David Crich, Sven N. Hobbie   +7 more
doaj   +1 more source

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

Stem Cells International, 2018
Protein acetylation is one of the most important posttranslational modifications catalyzed by acetyltransferases and deacetylases, through the addition and removal of acetyl groups to lysine residues. Lysine acetylation can affect protein-nucleic acid or
Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo   +2 more
doaj   +1 more source

Structure of the Histone Acetyltransferase Hat1 [PDF]

Cell, 1998
We have solved the crystal structure of the yeast histone acetyltransferase Hat1-acetyl coenzyme A (AcCoA) complex at 2.3 A resolution. Hat1 has an elongated, curved structure, and the AcCoA molecule is bound in a cleft on the concave surface of the protein, marking the active site of the enzyme.
Rolf Sternglanz, Venki Ramakrishnan, Robert N Dutnall, Stefan T. Tafrov   +3 more
openaire   +3 more sources

Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation.

Biochemistry, 2016
The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that includes more than 100000 members among eukaryotes and prokaryotes. Acetylation appears as a major regulatory post-translational modification and is as widespread
L. Favrot, J. Blanchard, O. Vergnolle
semanticscholar   +1 more source

Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members [PDF]

, 2008
Aims: The platelet-derived growth factor β-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death.
Wetterskog, Daniel
core   +1 more source

FgHAT2 is involved in regulating vegetative growth, conidiation, DNA damage repair, DON production and virulence in Fusarium graminearum

Journal of Integrative Agriculture, 2020
Histone lysine acetylation is catalyzed by acetyltransferases (HATs), which is important in regulating gene expression and physiological function in eukaryotic cells. HATs can be classified into two main types: A- and B-type HATs.
Wu-yun LÜ, Nan YANG, Zhe XU, Han DAI, Shuai TANG, Zheng-yi WANG   +5 more
doaj  

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Nature Communications, 2022
Here the authors show phosphorylation of heat shock factor 1 (HSF1) at S419 via the chromatin-bound kinase PLK1, promotes HSF1 recruitment of histone acetyltransferases and histone acetylation reader proteins TRIM33 and TRIM24, which actually also ...
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai   +8 more
doaj   +1 more source

Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)

International Journal of Molecular Sciences, 2016
General control non-repressible 5 (GCN5)-related N-acetyltransferases (GNAT) catalyze the transfer of an acyl moiety from acyl coenzyme A (acyl-CoA) to a diverse group of substrates and are widely distributed in all domains of life.
Abu Iftiaf Md Salah Ud-Din, A. Tikhomirova, A. Roujeinikova   +2 more
semanticscholar   +1 more source

Regulating histone acetyltransferases and deacetylases [PDF]

EMBO reports, 2003
Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with ...
Legube, G., Trouche, D.
openaire   +4 more sources