Results 41 to 50 of about 93,058 (385)

Regulation of skeletal muscle development and homeostasis by gene imprinting, histone acetylation and microRNA [PDF]

open access: yes, 2015
Epigenetics is defined as heritable information other that the DNA sequence itself. The concept implies that the regulation of gene expression is highly complex and epigenetics can control from fine tuning to permanent gene activation/deactivation ...
ADAMO, Sergio   +3 more
core   +2 more sources

Phenotypic Differentiation Within the aac(6) Aminoglycoside Resistance Gene Family Suggests a Novel Subtype IV of Contemporary Clinical Relevance

open access: yesAntibiotics
Background: Whole genome sequencing of clinical bacterial isolates holds promise in predicting their susceptibility to antibiotic therapy, based on a detailed understanding of the phenotypic manifestation of genotypic variation.
Michel Plattner   +7 more
doaj   +1 more source

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

open access: yesStem Cells International, 2018
Protein acetylation is one of the most important posttranslational modifications catalyzed by acetyltransferases and deacetylases, through the addition and removal of acetyl groups to lysine residues. Lysine acetylation can affect protein-nucleic acid or
Daniela Trisciuoglio   +2 more
doaj   +1 more source

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

open access: yesNature Communications, 2022
Here the authors show phosphorylation of heat shock factor 1 (HSF1) at S419 via the chromatin-bound kinase PLK1, promotes HSF1 recruitment of histone acetyltransferases and histone acetylation reader proteins TRIM33 and TRIM24, which actually also ...
Mitsuaki Fujimoto   +8 more
doaj   +1 more source

Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members [PDF]

open access: yes, 2008
Aims: The platelet-derived growth factor β-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death.
Wetterskog, Daniel
core   +1 more source

Positional proteomics reveals differences in N-terminal proteoform stability [PDF]

open access: yes, 2016
To understand the impact of alternative translation initiation on a proteome, we performed a proteome-wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes.
Brown JL   +4 more
core   +2 more sources

Structure of the Histone Acetyltransferase Hat1 [PDF]

open access: yesCell, 1998
We have solved the crystal structure of the yeast histone acetyltransferase Hat1-acetyl coenzyme A (AcCoA) complex at 2.3 A resolution. Hat1 has an elongated, curved structure, and the AcCoA molecule is bound in a cleft on the concave surface of the protein, marking the active site of the enzyme.
Rolf Sternglanz   +3 more
openaire   +3 more sources

Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation.

open access: yesBiochemistry, 2016
The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that includes more than 100000 members among eukaryotes and prokaryotes. Acetylation appears as a major regulatory post-translational modification and is as widespread
L. Favrot, J. Blanchard, O. Vergnolle
semanticscholar   +1 more source

FgHAT2 is involved in regulating vegetative growth, conidiation, DNA damage repair, DON production and virulence in Fusarium graminearum

open access: yesJournal of Integrative Agriculture, 2020
Histone lysine acetylation is catalyzed by acetyltransferases (HATs), which is important in regulating gene expression and physiological function in eukaryotic cells. HATs can be classified into two main types: A- and B-type HATs.
Wu-yun LÜ   +5 more
doaj  

Plant responses to abiotic stress: the chromatin context of transcriptional regulation [PDF]

open access: yes, 2017
The ability of plants to cope with abiotic environmental stresses such as drought, salinity, heat, cold or flooding relies on flexible mechanisms for re-programming gene expression. Over recent years it has become apparent that transcriptional regulation
Amtmann, Anna   +2 more
core   +1 more source

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