Results 71 to 80 of about 95,792 (372)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Members of the DUF231 Family are O-Acetyltransferases Catalyzing 2-O- and 3-O-Acetylation of Mannan

Plant and Cell Physiology, 2018
Mannans are hemicellulosic polysaccharides commonly found in the primary and secondary cell walls of land plants, and their mannosyl residues are often acetylated at O-2 and O-3.
R. Zhong, Dongtao Cui, Z. Ye
semanticscholar   +1 more source

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Nature Communications, 2021
Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product.
Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner   +22 more
doaj   +1 more source

A Continuous Assay Set to Screen and Characterize Novel Protein N-Acetyltransferases Unveils Rice General Control Non-repressible 5-Related N-Acetyltransferase2 Activity

Frontiers in Plant Science, 2022
Protein N-acetyltransferases (NATs) belong to the general control non-repressible 5 (Gcn5)-related N-acetyltransferases (GNATs) superfamily. GNATs catalyze the transfer of acetyl from acetyl-CoA to the reactive amine moiety of a wide range of acceptors ...
Thomas Asensio, Cyril Dian, Jean-Baptiste Boyer, Frédéric Rivière, Thierry Meinnel, Carmela Giglione   +5 more
doaj   +1 more source

Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N‐Cycling Bacterium

Advanced Science, EarlyView.
The vast reservoir of nitrogenous organic pollutants in industrial wastewaters can serve as untapped carbon‐nitrogen resources. This study employs the newly discovered Paracoccus sp. ZQW‐1 as a versatile chassis to simultaneously achieve N‐methylpyrrolidone (NMP) wastewater depuration and polyhydroxybutyrate (PHB) synthesis.
Ziqian Wang, Chunyu Du, Guanyu Zheng, Dahu Ding   +3 more
wiley   +1 more source

Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases

Computational and Structural Biotechnology Journal, 2020
N-terminal acetyltransferases (NATs) belong to the superfamily of acetyltransferases. They are enzymes catalysing the transfer of an acetyl group from acetyl coenzyme A to the N-terminus of polypeptide chains.
Angèle Abboud, Pierre Bédoucha, Jan Byška, Thomas Arnesen, Nathalie Reuter   +4 more
doaj   +1 more source

Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms [PDF]

, 2016
Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs).
A Ametzazurra, A Ben-Bassat, A Hershko, A Marintchev, A Murthi, A Pimenta-Marques, A Shemorry, A Staes, A Yoshikawa, AF Rope, AI Saeed, AL Pang, AO Helbig, B Polevoda, B Polevoda, B Polevoda, B Polevoda, B Polevoda, B Zybailov, BC Williams, CS Hwang, D Lang, D Zattas, DC Scott, EC Park, EV Koonin, G Liszczak, G Liszczak, G Liszczak, G Talavera, G Zhang, GM Forte, H Aksnes, HS Yoon, HY Zhu, I Dikiy, I Hofmann, J Sanchez, JD Jones, JL Brown, JM Singer, JP Casey, JR Mullen, K Hole, KK Starheim, KK Starheim, KK Starheim, LG Guilgur, LM Myklebust, M Gautschi, MA Larkin, MD Katinka, ML Angus-Hill, N Arnaudo, OK Song, P Van Damme, P Van Damme, P Van Damme, P Van Damme, P Van Damme, P Van Damme, R Behnia, R Evjenth, R Shemesh, RD Finn, RD Silva, RP Moerschell, S Capella-Gutierrez, S Goetze, S Hoshiyasu, S Tanaka, SF Altschul, SR Setty, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Arnesen, T Esmailpour, T van Welsem, TB Chou, TV Dinh, TV Kalvik, TY James, WV Bienvenut, WV Bienvenut, Y Wang, YY Chang   +88 more
core   +2 more sources

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source