Results 41 to 50 of about 53,594 (279)

A Rare Case Received A Late Diagnosis Despite Recurrent Hospital Admissions: Infantile Hypertrophic Pyloric Stenosis

Çocuk Dergisi, 2021
Infantile hypertrophic pyloric stenosis is the narrowing of the pyloric duct due to hypertrophy of the pylorus. The disease manifests itself with gushing and non-bile vomiting in babies after feeding.
Cüneyt Uğur, Enes Ay, Hasan Madenci
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Carp Edema Virus Infection Is Associated With Severe Metabolic Disturbance in Fish

Frontiers in Veterinary Science, 2021
Significant mortalities associated with emerging viral diseases are challenging the economy of common carp aquaculture. As such, there is an increased need to disentangle how infected fish cope with progressive disease pathology and lose the ability for ...
Jiri Pikula, Jiri Pikula, Lubomir Pojezdal, Ivana Papezikova, Ivana Papezikova, Hana Minarova, Hana Minarova, Ivana Mikulikova, Hana Bandouchova, Hana Bandouchova, Jana Blahova, Małgorzata Bednarska, Jan Mares, Miroslava Palikova, Miroslava Palikova   +14 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets. [PDF]

PLoS ONE, 2012
The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates. The aim of the present study was to examine its effect on hemodynamic changes and hydrogen peroxide (H(2)O(2 ...
Jiang-Qin Liu, Namdar Manouchehri, Tze-Fun Lee, Mingzhu Yao, David L Bigam, Po-Yin Cheung   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Tubular Handling of Uric Acid and Factors Influencing Its Renal Excretion: A Short Review [PDF]

European Medical Journal Nephrology, 2016
In this review, the authors briefly examine the most recent evidence concerning the role of several proteins involved in tubular urate transport. They also analyse the influence of extracellular volume, electrolyte disorders, acid-base imbalance, and ...
Tubular Handling of Uric Acid and Factors Influencing Its Renal Excretion: A Short Review, Gabriele Pricoco, Damiano Cantone, Elisa Marino, Francesca Bruno   +4 more
doaj  

Critical Response Training for Surgical Interns

MedEdPORTAL, 2010
Introduction In order to provide safe, timely, and effective care for our patients, it is imperative that surgical interns are prepared to recognize and manage acute postoperative complications, particularly those emergencies which are life-threatening ...
Mara Antonoff, Jeffrey Chipman, Connie Schmitz, Jonathan DCunha   +3 more
doaj   +1 more source