Results 191 to 200 of about 20,488 (221)

S‐Nitrosothiols as Thiol‐Protecting Groups for Controlled Thiol‐Maleimide Crosslinking of Homogeneous Soft Hydrogels

Advanced Materials, EarlyView.
Rapid thiol‐maleimide addition frequently outpaces mixing, resulting in heterogeneous hydrogels. S‐nitrosothiols act as thiol‐protecting groups, allowing uniform mixing with maleimide‐functionalized polymers before gelation. Sodium thiosulfate or sodium ascorbate then regenerates thiols on demand, triggering controlled thiol‐maleimide crosslinking ...
Julian A. Serna, Michelle J. Iwohn, Maximilian Seifermann, Stefan Heißler, Maike Schliephake, Franziska Dopp, Claudia Muhle‐Goll, Pavel A. Levkin   +7 more
wiley   +1 more source

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Glutamate potentiates heterologously expressed homomeric acid‐sensing ion channel 1a

Synapse, 2022
AbstractAcid‐sensing ion channels (ASICs) participate in synaptic transmission due to the acidic content of synaptic vesicles, but their contribution to postsynaptic currents is small. This has stimulated attempts to find endogenous ASIC potentiators that could enhance ASIC‐mediated currents to physiologically relevant values.
Vasilii, Shteinikov, Konstantin, Evlanenkov, Konstantin, Bolshakov, Denis, Tikhonov   +3 more
openaire   +2 more sources

Histamine selectively potentiates acid-sensing ion channel 1a

Neuroscience Letters, 2016
Although acid-sensitive ion channels (ASICs) play an important role in brain functions, the exact mechanism of their physiological activation remain unclear. A possible answer to the intriguing question is that some presently unknown endogenous ligand(s) positively modulate ASICs and enhance their responses to physiologically significant level.
Elina I, Nagaeva, Tatiana B, Tikhonova, Lev G, Magazanik, Denis B, Tikhonov   +3 more
openaire   +2 more sources

Modulation of Slow Desensitization (Tachyphylaxis) of Acid-Sensing Ion Channel (ASIC)1a

Cellular and Molecular Neurobiology, 2022
Among the proton-activated channels of the ASIC family, ASIC1a exhibits a specific tachyphylaxis phenomenon in the form of a progressive decrease in the response amplitude during a series of activations. This process is well known, but its mechanism is poorly understood. Here, we demonstrated a partial reversibility of this effect using long-term whole-
Margarita S. Komarova, Andrey R. Bukharev, Natalia N. Potapieva, Denis B. Tikhonov   +3 more
openaire   +2 more sources

Regulating Factors in Acid-Sensing Ion Channel 1a Function

Neurochemical Research, 2015
In recent years, research of acid sensing ion channels (ASICs) has increased tremendously, especially studies focusing on ASIC1a, which plays a critical role in many important physiologic and pathological functions. This review will discuss factors regulating ASIC1a expression and activity in various conditions and will provide a theoretical basis for ...
Yinghong, Wang, Zaven, O'Bryant, Huan, Wang, Yan, Huang   +3 more
openaire   +2 more sources

Neuronal acid-sensing ion channel 1a regulates neuron-to-glioma synapses

2023
ABSTRACT Neuronal activity promotes high-grade glioma progression via secreted proteins and neuron-to-glioma synapses, and glioma cells boost neuronal activity to further reinforce the malignant cycle. Whereas strong evidence supports that the activity of neuron-to-glioma synapses accelerates tumor progression, the ...
Gyeongah Park, Zhen Jin, Qian Ge, Yuan Pan, Jianyang Du   +4 more
openaire   +2 more sources

Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen

Journal of Medicinal Chemistry, 2017
A growing body of evidence links certain aspects of nonsteroidal anti-inflammatory drug (NSAID) pharmacology with acid-sensing ion channels (ASICs), a small family of excitatory neurotransmitter receptors implicated in pain and neuroinflammation. The molecular basis of NSAID inhibition of ASICs has remained unknown, hindering the exploration of this ...
Timothy Lynagh, José Luis Romero-Rojo, Camilla Lund, Stephan A. Pless   +3 more
openaire   +3 more sources

Conformational plasticity of human acid-sensing ion channel 1a

Summary Acid-sensing ion channels (ASICs) are typically activated by acidic environments and contribute to nociception and synaptic plasticity. ASIC1a is the most abundant subunit in the central nervous system and forms homomeric channels permeable to Na + and Ca 2+
James Cahill, Kimberly A. Hartfield, Stephanie Andrea Heusser, Mette Homann Poulsen, Craig Yoshioka, Stephan Alexander Pless, Isabelle Baconguis   +6 more
openaire   +2 more sources

Evidence for role of acid-sensing ion channel 1a in chronic rhinosinusitis with nasal polyps

European Archives of Oto-Rhino-Laryngology, 2021
A variety of inflammatory cells are infiltrated histologically in sinonasal mucosa of chronic rhinosinusitis with nasal polyps (CRSwNP), especially CRSwNP with asthma. Acid-sensing ion channel 1a (ASIC1a) is essential in the process of sensing acidification and triggering inflammation. Whereas, its role and mechanism in CRSwNP remain uncertain.
Ru Tang, Guangyi Ba, Mingxian Li, Zhipeng Li, Haibo Ye, Hai Lin, Weitian Zhang   +6 more
openaire   +2 more sources

Chloroquine impairs visual transduction via modulation of acid sensing ion channel 1a

Toxicology Letters, 2014
Acid-sensing ion channels (ASICs) are extracellular pH sensors activated by protons, which influence retinal activity and phototransduction. Among all ASICs, ASIC1a is abundantly expressed in the retina and involved in normal retinal activity. Chloroquine, which has been used in the treatment of malaria, rheumatoid arthritis and systemic lupus ...
Xiaoyu, Li, Jianchun, Fei, Zhen, Lei, Kejing, Liu, Jianbo, Wu, Tao, Meng, Jingui, Yu, Jingxin, Li   +7 more
openaire   +2 more sources