Results 201 to 210 of about 20,488 (221)

The Expression and Phosphorylation of Acid Sensing Ion Channel 1a in the Brain of a Mouse Model of Phenylketonuria

International Journal of Neuroscience, 2011
The acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel enriched in the mammalian brain. Recent studies suggest its diverse roles in ischemic acidosis, neurodegenerative diseases, and cognitive processes. Phenylketonuria (PKU) is the most commonly inherited defect in amino acid metabolism.
Lili, Liang, Xuefan, Gu, Duan, Li, Lihua, Lu   +3 more
openaire   +2 more sources

Acid sensing ion channel 1a deficiencies contribute to glucose homeostasis

Physiology
Acid-sensing ion channel 1a (ASIC1a), a proton-gated ion channel that senses alterations in pH, contributes to cellular responses associated with acidosis. Metabolic, tissue, and cellular acidosis are central to various disease processes, which include cardiometabolic disease (CMD).
Xavier DeLeon, Selina Garcia, Nikki Jernigan   +2 more
openaire   +1 more source

Effect of acid-sensing ion channel 1a on the process of liver fibrosis under hyperglycemia

Biochemical and Biophysical Research Communications, 2015
Metabolic syndrome characterized by hyperglycemia contributes to nonalcoholic steatohepatitis-associated liver fibrosis. This study was to investigate the effects of Acid-sensing ion Channel 1a (ASIC1a) on the process of liver fibrosis under hyperglycemia. Results showed that high glucose significantly worsen the pathology of liver fibrosis in vivo. In 
Huan, Wang, Ying-hong, Wang, Feng, Yang, Xiao-feng, Li, Yuan-yao, Tian, Ming-ming, Ni, Long-quan, Zuo, Xiao-Ming, Meng, Yan, Huang   +8 more
openaire   +2 more sources

Acid-sensing ion channel 3: An analgesic target

Channels, 2021
Ewan Smith, Taufiq Rahman, Jasdip Singh Dulai   +2 more
exaly  

Paradoxical Potentiation of Acid-Sensing Ion Channel 3 (ASIC3) by Amiloride via Multiple Mechanisms and Sites Within the Channel

Frontiers in Physiology, 2021
Christopher Benson, Daniel S Matasic, Snyder Peter M   +2 more
exaly  

Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia–Reperfusion Injury

Circulation, 2021
Peter Macdonald, Porrello Enzo R, Robert Hatch   +2 more
exaly  

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Proceedings of the National Academy of Sciences of the United States of America, 2017
Glenn KING, Yanni Chin, Irène Chassagnon   +2 more
exaly  

The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization

Journal of Biological Chemistry, 2016
Aram Krauson, Marcelo Carattino
exaly  

Differential regulation of locomotor activity to acute and chronic cocaine administration by acid-sensing ion channel 1a and 2 in adult mice

Neuroscience, 2013
Chu Xp
exaly  

Global Ischemia Induces Expression of Acid-Sensing Ion Channel 2a in Rat Brain

Journal of Cerebral Blood Flow and Metabolism, 2001
Masabumi Minami, Kunlin Jin, R P Simon
exaly