Results 151 to 160 of about 3,011 (167)

[Acid-Sensing Ion Channels (ASICs) in pain].

Biologie aujourd'hui, 2015
The discovery of new drug targets represents a real opportunity for developing fresh strategies against pain. Ion channels are interesting targets because they are directly involved in the detection and the transmission of noxious stimuli by sensory fibres of the peripheral nervous system and by neurons of the spinal cord.
openaire   +1 more source

Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment

2009
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in peripheral sensory neurons and in neurons of the central nervous system. Recent studies have demonstrated that activation of these channels plays an important role in a variety of physiological and pathological processes such as nociception, mechanosensation ...
openaire   +2 more sources

Neuroprotective effects of inhibitors of Acid-Sensing ion channels (ASICs) in optic nerve crush model in rodents

Current Eye Research, 2017
The purpose of the current study was to assess the potential involvement of acid-sensing ion channel 1 (ASIC1) in retinal ganglion cell (RGC) death and investigate the neuroprotective effects of inhibitors of ASICs in promoting RGC survival following optic nerve crush (ONC).ASIC1 protein was significantly increased in optic nerve extracts at day 7 ...
Dorota L. Stankowska, Brett H. Mueller, Hidehiro Oku, Tsunehiko Ikeda, Adnan Dibas   +4 more
openaire   +2 more sources

Physiological Functions of Acid-Sensing Ion Channels (ASICS) in the Brain

Journal of Evolutionary Biochemistry and Physiology, 2023
openaire   +1 more source

The role of acid-sensing ion channels (ASICs) in exercise-induced muscle pain

Pain is a universal experience. While acute pain can be protective against harm and injury, pain can also become persistent and chronic, causing tremendous suffering and financial burden to society. Despite the burden of chronic pain, efforts at treatment have fallen short.
openaire   +1 more source

Acid-sensing (proton-gated) ion channels (ASICs)

Trends in Pharmacological Sciences, 2001
openaire   +1 more source

The Tarantula Toxin Psalmotoxin 1 Inhibits Acid-sensing Ion Channel (ASIC) 1a by Increasing Its Apparent H+ Affinity

Journal of General Physiology, 2005
Xuanmao Chen, Stefan Grunder
exaly  

Identification of the Ca2+ Blocking Site of Acid-sensing Ion Channel (ASIC) 1

Journal of General Physiology, 2004
Martin Paukert, Stefan Grunder, Michael Pusch   +2 more
exaly  

Global Ischemia Induces Expression of Acid-Sensing Ion Channel 2a in Rat Brain

Journal of Cerebral Blood Flow and Metabolism, 2001
Masabumi Minami, Kunlin Jin, R P Simon
exaly  

Differential regulation of locomotor activity to acute and chronic cocaine administration by acid-sensing ion channel 1a and 2 in adult mice

Neuroscience, 2013
Chu Xp
exaly