Results 141 to 150 of about 3,011 (167)

Acid Sensing Ion Channel 1a (ASIC1a) Mediates Activity-induced Pain by Modulation of Heteromeric ASIC Channel Kinetics

Neuroscience, 2018
Chronic muscle pain is acutely worsened by exercise. Acid sensing ion channels (ASIC) are heteromeric channels expressed in muscle sensory neurons that detect decreases in pH. We have previously shown ASIC3 is important in activity-induced hyperalgesia. However, ASICs form heteromers with ASIC1a being a key component in sensory neurons.
Christopher Benson, Kathleen Sluka, Nicholas Gregory   +2 more
exaly   +3 more sources

Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models

Psychopharmacology, 2008
Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and anxiety.The present experiments evaluated ...
Stacey J Sukoff Rizzo, Jason M Dwyer, Sharon Rosenzweig-Lipson   +2 more
exaly   +3 more sources

Biophysical properties of acid-sensing ion channels (ASICs)

Neuropharmacology, 2015
Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely sensitive to extracellular protons and can sense transient as well as sustained acidification. In this review, we will discuss activation and desensitization of ASICs by protons.
Grunder S, Pusch M
openaire   +3 more sources

Acid-Sensing Ion Channels (ASICs): Pharmacology and implication in pain

Pharmacology & Therapeutics, 2010
Tissue acidosis is a common feature of many painful conditions. Protons are indeed among the first factors released by injured tissues, inducing a local pH fall that depolarizes peripheral free terminals of nociceptors and leads to pain. ASICs are excitatory cation channels directly gated by extracellular protons that are expressed in the nervous ...
Deval, Emmanuel, Gasull, Xavier, Noël, Jacques, Salinas, Miguel, Baron, Anne, Diochot, Sylvie, Lingueglia, Eric   +6 more
openaire   +4 more sources

Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish

Neuroscience Letters, 2013
In detecting chemical properties of food, different molecules and ion channels are involved including members of the acid-sensing ion channels (ASICs) family. Consistently ASICs are present in sensory cells of taste buds of mammals. In the present study the presence of ASICs (ASIC1, ASIC2, ASIC3 and ASIC4) was investigated in the taste buds of adult ...
Viña E, Parisi V, Cabo R, LAURA', Rosaria, López Velasco S, López Muñiz A, García Suárez O, GERMANA', Antonino, Vega J.A.   +8 more
openaire   +3 more sources

Increased acid-sensing ion channel ASIC-3 in inflamed human intestine

European Journal of Gastroenterology & Hepatology, 2001
Acid-sensing ion channels (ASICs) are expressed by rat sensory neurons and may mediate pain associated with tissue acidosis after inflammation or injury. Our aim was to examine the molecular forms and localization of ASICs in human intestine and dorsal root ganglia using immunochemical techniques, and to measure the effects of inflammation and injury ...
Y, Yiangou, P, Facer, J A, Smith, L, Sangameswaran, R, Eglen, R, Birch, C, Knowles, N, Williams, P, Anand   +8 more
openaire   +2 more sources

Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish

Cell and Tissue Research, 2015
Acid-sensing ion channels (ASICs) are H(+)-gated, voltage-insensitive cation channels involved in synaptic transmission, mechanosensation and nociception. Different ASICs have been detected in the retina of mammals but it is not known whether they are expressed in adult zebrafish, a commonly used animal model to study the retina in both normal and ...
Viña, E, PARISI, VALENTINA, Sánchez Ramos, C, Cabo, R, GUERRERA, Maria Cristina, Quirós, Lm, GERMANA', Antonino, Vega, Ja, García Suárez, O.   +8 more
openaire   +3 more sources

Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology

2008
Although brain pH is tightly controlled, it can be more dynamic than commonly appreciated. Physiological fluctuations in extracellular pH provide ample opportunity for protons to influence synaptic signaling. A number of synaptic proteins are modified by extracellular pH.
John A. Wemmie, Xiang-ming Zha, Michael J. Welsh   +2 more
openaire   +1 more source

Acid-sensing ion channels (ASICs) influence excitability of stellate neurons in the mouse cochlear nucleus

Journal of Comparative Physiology A, 2019
Acid-sensing ion channels (ASICs) are voltage-independent and proton-gated channels. In this study, we aimed to test the hypothesis whether ASICs might be involved in modifying the excitability of stellate cells in the cochlear nucleus (CN). We determined gene expressions of ASIC1, ASIC2 and ASIC3 in the CN of BALB/mice. ASIC currents in stellate cells
Ziya Cakir, Caner Yildirim, Ilay Buran, Ebru Etem Önalan, Ramazan Bal   +4 more
openaire   +2 more sources

Molecular cloning and characterization of human acid sensing ion channel (ASIC)2 gene promoter

Gene, 2003
Acid sensing ion channel (ASIC)2 belongs to the amiloride-sensitive Na(+)-channel/ degenerin family. Our previous studies suggested that differential regulation of ASIC2 expression occurs between high-grade glial-derived tumor cells and normal astrocytes. To investigate the mechanisms involved in the regulation of ASIC2 gene expression, the human ASIC2
Jiazeng, Xia, Zhen Hong, Zhou, James K, Bubien, Catherine M, Fuller, James M, Markert, Timothy B, Mapstone, G Yancey, Gillespie, Dale J, Benos   +7 more
openaire   +2 more sources