Results 71 to 80 of about 3,329,624 (262)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Acid and Alkaline Phosphatase Activity in the Indian Apple Snail Pila globosa (Swainson) During Aestivation [PDF]
Journal of Stress Physiology & Biochemistry, 2023 The Indian apple snail Pila globosa (Swainson) experiences an annual cycle of aestivation (summer sleep) as a survival strategy during a hot and dry period to avoid damage from high temperatures and the risk of desiccation.
Roshani Patel, Anil Kurhe
doaj
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Modifications induced by ascorbic acid on alkaline phosphatase fluorescence
, 1984 Ascorbic acid, isoascorbic acid and dehydroascorbic acid quench the tryptophyl fluorescence of alkaline phosphatase. The quenching is protein aspecific, although its extent reflects the different inhibitory efficiency of the compounds.
Mordente, Alvaro, Meucci, Elisabetta
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Surface phosphatase activity of peltigera and cladonia lichens [PDF]
, 1994 This study examines the effects of environmental factors on the surface phosphatase activities of the lichens Peltigera canina (L.) Willd., P. praetextata (Flōrke. ex Sommerf) Vain, and Cladonia arbuscula (Wallr.) Rabenh. Four plants of each species were
Stevenson, Paul A.R.J.
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Bacterial and fungal contributions to the production of phosphatases in arable and forest soils
Frontiers in Soil SciencePhosphatases play a key role in the mineralization of organic phosphorus in soils; however, the relative contributions of bacteria and fungi to phosphatase activities remain unclear. Sources of activities of two phosphomonoesterases (acid phosphatase and
Makimi Sugawa +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Filament structure and phosphatase activity in the Rivulariaceae [PDF]
, 1989 A study was carried out on phosphatase activity, phosphate uptake and its relationship to hair formation in the Rivulariaceae. The Rivulariaceae was chosen as it is a widespread taxon, where hair formation is a common occurrence, and previous studies ...
Grainger, Stewart L.J.
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source