Results 41 to 50 of about 324,577 (276)

Responses of Free-Living Planktonic Bacterial Communities to Experimental Acidification and Warming

Microorganisms, 2023
Climate change driven by human activities encompasses the increase in atmospheric CO2 concentration and sea-surface temperature. Little is known regarding the synergistic effects of these phenomena on bacterial communities in oligotrophic marine ...
Anastasia Tsiola, Evangelia Krasakopoulou, Daniele Daffonchio, Constantin Frangoulis, Tatiana M. Tsagaraki, Stilianos Fodelianakis, Paraskevi Pitta   +6 more
doaj   +1 more source

Marine bivalve geochemistry and shell ultrastructure from modern low pH environments [PDF]

, 2011
. Bivalve shells can provide excellent archives of past environmental change but have not been used to interpret ocean acidification events. We investigated carbon, oxygen and trace element records from different shell layers in the mussels Mytilus ...
Baggini, C, Buhl, D, Fehr, KT, Griesshaber, E, Hahn, S, Hall-Spencer, JM, Immenhauser, A, Rodolfo-Metalpa, R, Schmahl, WW   +8 more
core   +2 more sources

Ongoing transients in carbonate compensation [PDF]

, 2010
Uptake of anthropogenic CO2 is acidifying the oceans. Over the next 2000 years, this will modify the dissolution and preservation of sedimentary carbonate.
Andreas F. Hofmann, Archer, Archer, Archer, Archer, Archer, Bernard P. Boudreau, Berner, Boudreau, Boudreau, Broecker, Broecker, Broecker, Broecker, Broecker, Caldeira, Filip J. R. Meysman, Gehlen, Gruber, Jack J. Middelburg, Keir, Key, Khatiwala, Knox, Lane, Lenton, Merico, Millero, Munhoven, Oxburgh, Ridgwell, Ridgwell, Ridgwell, Riebesell, Roberts, Sarmiento, Sarmiento, Siegenthaler, Stephens, Toggweiler, Wigley, Zeebe, Zeebe   +42 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Lysosomal Acidification Mechanisms [PDF]

Annual Review of Physiology, 2012
Lysosomes, the terminal organelles on the endocytic pathway, digest macromolecules and make their components available to the cell as nutrients. Hydrolytic enzymes specific to a wide range of targets reside within the lysosome; these enzymes are activated by the highly acidic pH (between 4.5 and 5.0) in the organelles' interior. Lysosomes generate and
openaire   +2 more sources

Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice [PDF]

, 2014
Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also ...
Colettis, Natalia Claudia, Gonzalez, Laura Elisabeth, González Inchauspe, Carlota María Fabiola, Lino, Noelia Gisele, Uchitel, Osvaldo Daniel, Urbano Suarez, Francisco Jose, Vattino, Lucas Gabriel, Wemmie, John A., Wunsch, Amanda M.   +8 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Recovery of Streams in the Harz National Park (Germany)—The Attenuation of Acidification

Ecologies
Between 1995 and 2022, 19 measuring points in small and medium sized streams in the Harz National Park, Germany, were sampled. The samples were evaluated in terms of their macroinvertebrate (MI) biology and hydrochemistry.
Uta Langheinrich, Kilian E. C. Smith, Jose Ramon Arevalo, Fabian Schwarz, Volker Lüderitz   +4 more
doaj   +1 more source

Evidence of Springwater Acidification in the Vosges Mountains (North-East of France): Influence of Bedrock Buffering Capacity [PDF]

, 1999
Investigations on springwater acidity were carried out in the Vosges mountains (north-eastern France). Acid or poorly buffered spring and streamwaters were detected in the same area.
Dambrine, Etienne, Février, Clotilde, Party, Jean-Paul, Probst, Anne, Stussi, J.M., Thomas, Anne-Laure   +5 more
core   +2 more sources