Results 31 to 40 of about 122,020 (253)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ACIDIFICATION

, 2014
Acidification is caused by emissions of sulphur dioxide (SO2), nitrogen oxides (NOx), and ammonia (NH3), of which sulphur emissions are the primary source. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789 ...
  +5 more sources

Recovery of Streams in the Harz National Park (Germany)—The Attenuation of Acidification

Ecologies
Between 1995 and 2022, 19 measuring points in small and medium sized streams in the Harz National Park, Germany, were sampled. The samples were evaluated in terms of their macroinvertebrate (MI) biology and hydrochemistry.
Uta Langheinrich, Kilian E. C. Smith, Jose Ramon Arevalo, Fabian Schwarz, Volker Lüderitz   +4 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Reproductive Response of Platynothrus peltifer (C.L. Koch, 1839) to Continuous Nitrogen Deposition

Diversity
Continuous nitrogen deposition threatens ecosystems by acidifying soils, causing a stoichiometric imbalance in the vegetation and ultimately, the disappearance of plant and animal species.
Marie-Charlott Petersdorf, Joren Bruggink, Evy A. de Nijs, Henk Siepel   +3 more
doaj   +1 more source

NAD-Glycohydrolase Depletes Intracellular NAD+ and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A Streptococcus in Endothelial Cells

Frontiers in Microbiology, 2018
Group A Streptococcus (GAS) is a human pathogen causing a wide spectrum of diseases, from mild pharyngitis to life-threatening necrotizing fasciitis. GAS has been shown to evade host immune killing by invading host cells.
Cheng-Lu Hsieh, Hsuan-Min Huang, Shu-Ying Hsieh, Po-Xing Zheng, Yee-Shin Lin, Yee-Shin Lin, Chuan Chiang-Ni, Chuan Chiang-Ni, Pei-Jane Tsai, Shu-Ying Wang, Ching-Chuan Liu, Ching-Chuan Liu, Jiunn-Jong Wu, Jiunn-Jong Wu   +13 more
doaj   +1 more source

Early Diagenesis in the Hypoxic and Acidified Zone of the Northern Gulf of Mexico: Is Organic Matter Recycling in Sediments Disconnected From the Water Column?

Frontiers in Marine Science, 2021
Hypoxia and associated acidification are growing concerns for ecosystems and biogeochemical cycles in the coastal zone. The northern Gulf of Mexico (nGoM) has experienced large seasonal hypoxia for decades linked to the eutrophication of the continental ...
Christophe Rabouille, Bruno Lansard, Shannon M. Owings, Nancy N. Rabalais, Bruno Bombled, Edouard Metzger, Julien Richirt, Eryn M. Eitel, Anthony D. Boever, Jordon S. Beckler, Martial Taillefert   +10 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source