Results 51 to 60 of about 327,594 (295)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Reproductive Response of Platynothrus peltifer (C.L. Koch, 1839) to Continuous Nitrogen Deposition

Diversity
Continuous nitrogen deposition threatens ecosystems by acidifying soils, causing a stoichiometric imbalance in the vegetation and ultimately, the disappearance of plant and animal species.
Marie-Charlott Petersdorf, Joren Bruggink, Evy A. de Nijs, Henk Siepel   +3 more
doaj   +1 more source

NAD-Glycohydrolase Depletes Intracellular NAD+ and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A Streptococcus in Endothelial Cells

Frontiers in Microbiology, 2018
Group A Streptococcus (GAS) is a human pathogen causing a wide spectrum of diseases, from mild pharyngitis to life-threatening necrotizing fasciitis. GAS has been shown to evade host immune killing by invading host cells.
Cheng-Lu Hsieh, Hsuan-Min Huang, Shu-Ying Hsieh, Po-Xing Zheng, Yee-Shin Lin, Yee-Shin Lin, Chuan Chiang-Ni, Chuan Chiang-Ni, Pei-Jane Tsai, Shu-Ying Wang, Ching-Chuan Liu, Ching-Chuan Liu, Jiunn-Jong Wu, Jiunn-Jong Wu   +13 more
doaj   +1 more source

Early Diagenesis in the Hypoxic and Acidified Zone of the Northern Gulf of Mexico: Is Organic Matter Recycling in Sediments Disconnected From the Water Column?

Frontiers in Marine Science, 2021
Hypoxia and associated acidification are growing concerns for ecosystems and biogeochemical cycles in the coastal zone. The northern Gulf of Mexico (nGoM) has experienced large seasonal hypoxia for decades linked to the eutrophication of the continental ...
Christophe Rabouille, Bruno Lansard, Shannon M. Owings, Nancy N. Rabalais, Bruno Bombled, Edouard Metzger, Julien Richirt, Eryn M. Eitel, Anthony D. Boever, Jordon S. Beckler, Martial Taillefert   +10 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Impact of ocean acidification on microzooplankton grazing dynamics

Frontiers in Marine Science
This study examines the potential impacts of projected atmospheric carbon dioxide (pCO2) levels reaching 800 ppm by the end of the century, focusing on ocean acidification effects on marine ecosystems in the coastal areas of Bohai.
Wenting Shi, Wenting Shi, Wenting Shi, Xiaoting Fu, Xiaoting Fu, Xiaoting Fu, Yabo Han, Yabo Han, Yabo Han, Jiahui Qin, Jiahui Qin, Jiahui Qin, Jun Sun, Jun Sun, Jun Sun   +14 more
doaj   +1 more source

Changes in Eutric Cambisol due to long-term mineral fertilisation: A case study in Serbia

Italian Journal of Agronomy, 2022
The paper presents the results of a 50-year fertilisation experiment on Eutric Cambisol with increasing doses of nitrogen and constant doses of phosphorus and potassium.
Nikola Koković, Goran Jačimović, Biljana Sikirić, Vladimir Čirić, Vladan Ugrenović, Aigul Zhapparova, Elmira Saljnikov   +6 more
doaj   +1 more source

USING VOLCANIC MARINE CO2 VENTS TO STUDY THE EFFECTS OF OCEAN ACIDIFICATION ON BENTHIC BIOTA: HIGHLIGHTS FROM CASTELLO ARAGONESE D’ISCHIA (TYRRHENIAN SEA) [PDF]

, 2010
Current research into ocean acidification is mainly being carried out using short-term experiments whereby CO2 levels are manipulated in aquaria and enclosures.
Buia, MC, Cigliano, M, Cocito, S, Gambi, MC, Hall-Spencer, JM, Lombardi, C, Lorenti, M, Patti, FP, Porzio, L, Rodolfo-Metalpa, R, Scipione, MC   +10 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source