Results 51 to 60 of about 242,934 (307)

The contribution of natural and anthropogenic causes to soil acidification rates under different fertilization practices and site conditions in southern China.

Science of the Total Environment
Excessive application of mineral fertilizers has accelerated soil acidification in China, affecting crop production when the pH drops below a critical value.
Xing-Juan Zhu, Gerard H. Ros, Ming-Gang Xu, Dong-Hao Xu, Ze-Jiang Cai, Nan Sun, Y. Duan, W. de Vries   +7 more
semanticscholar   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Recovery of Streams in the Harz National Park (Germany)—The Attenuation of Acidification

Ecologies
Between 1995 and 2022, 19 measuring points in small and medium sized streams in the Harz National Park, Germany, were sampled. The samples were evaluated in terms of their macroinvertebrate (MI) biology and hydrochemistry.
Uta Langheinrich, Kilian E. C. Smith, Jose Ramon Arevalo, Fabian Schwarz, Volker Lüderitz   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Reproductive Response of Platynothrus peltifer (C.L. Koch, 1839) to Continuous Nitrogen Deposition

Diversity
Continuous nitrogen deposition threatens ecosystems by acidifying soils, causing a stoichiometric imbalance in the vegetation and ultimately, the disappearance of plant and animal species.
Marie-Charlott Petersdorf, Joren Bruggink, Evy A. de Nijs, Henk Siepel   +3 more
doaj   +1 more source

NAD-Glycohydrolase Depletes Intracellular NAD+ and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A Streptococcus in Endothelial Cells

Frontiers in Microbiology, 2018
Group A Streptococcus (GAS) is a human pathogen causing a wide spectrum of diseases, from mild pharyngitis to life-threatening necrotizing fasciitis. GAS has been shown to evade host immune killing by invading host cells.
Cheng-Lu Hsieh, Hsuan-Min Huang, Shu-Ying Hsieh, Po-Xing Zheng, Yee-Shin Lin, Yee-Shin Lin, Chuan Chiang-Ni, Chuan Chiang-Ni, Pei-Jane Tsai, Shu-Ying Wang, Ching-Chuan Liu, Ching-Chuan Liu, Jiunn-Jong Wu, Jiunn-Jong Wu   +13 more
doaj   +1 more source

Early Diagenesis in the Hypoxic and Acidified Zone of the Northern Gulf of Mexico: Is Organic Matter Recycling in Sediments Disconnected From the Water Column?

Frontiers in Marine Science, 2021
Hypoxia and associated acidification are growing concerns for ecosystems and biogeochemical cycles in the coastal zone. The northern Gulf of Mexico (nGoM) has experienced large seasonal hypoxia for decades linked to the eutrophication of the continental ...
Christophe Rabouille, Bruno Lansard, Shannon M. Owings, Nancy N. Rabalais, Bruno Bombled, Edouard Metzger, Julien Richirt, Eryn M. Eitel, Anthony D. Boever, Jordon S. Beckler, Martial Taillefert   +10 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Impact of ocean acidification on microzooplankton grazing dynamics

Frontiers in Marine Science
This study examines the potential impacts of projected atmospheric carbon dioxide (pCO2) levels reaching 800 ppm by the end of the century, focusing on ocean acidification effects on marine ecosystems in the coastal areas of Bohai.
Wenting Shi, Wenting Shi, Wenting Shi, Xiaoting Fu, Xiaoting Fu, Xiaoting Fu, Yabo Han, Yabo Han, Yabo Han, Jiahui Qin, Jiahui Qin, Jiahui Qin, Jun Sun, Jun Sun, Jun Sun   +14 more
doaj   +1 more source