Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Effect of ultrasonic and infrared treatments on microbial population, physicochemical properties, and total phenols of sprouted wheat powder [PDF]
فناوریهای جدید در صنعت غذاSprouting is a simple technique for improving the nutritional and quality characteristics of cereal grains. The purpose of this work was to examine ultrasonic pretreatment and drying methods (hot-air and infrared) on microbial population (total bacterial
samira Amin-Ekhlas +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Quality of drinking water from the agricultural area treated with pitcher water filters
Roczniki Panstwowego Zakladu Higieny, 2018 Background. Home methods of drinking water treatment through filtration have recently become quite popular. Objective. The aim of the study was to compare chemical composition of unfiltered water with water filtered in households with pitcher water ...
Elżbieta Królak +3 more
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INFLUENCE OF CHEMICAL FERTILIZATION ON STRAWBERRY FRUIT PROPERTIES [PDF]
Fruit Growing Research, 2012 The worldwide trend of plantations fertilization imposed a new concept in this field. On one hand, it was abandoned the idea of using large amounts of fertilizer to force the obtaining of high yields, and on the other hand, increasingly require more and ...
Alina Florea, Alexandru Teodorescu
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THE HOMOGENIZED VEGETABLE PASTES AND MARINADES WITH BERRY COMPONENTA
Современная наука и инновации, 2022 In article possibility of use of a residue of berries of cowberry and a cranberry is studied for production of the homogenized pastes and marinades with a residue of berries of cowberry and a cranberry ofthe increased microbiological firmness.
Galina Valentinovna Ivanova +1 more
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Quality of Physalis (Physalis pubescens L.) juice packaged in glass bottles and flexible laminated packs during storage at 5°C [PDF]
, 2009 Husk tomato (Physalis pubescens L.) is one of the important 100 species in the Physalis genus of the Solanaceae family. Among unexploited tropical fruits, Physalis is a very promising fruit.
El Sheikha, Aly +4 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
INFLUENCE OF TYPE STARTER CULTURE ON THE PROPERTIES OF THE FERMENTED ICE CREAM MIXTURE
Вестник Северо-Кавказского федерального университета, 2022 The article presents the results of physic-chemical, microbiological and sensory analysis of the ice cream mixture samples fermented different types of the starter ...
Valida R. Akhmedova +3 more
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